Search Results - "Drabkin, H A"

HOX expression patterns identify a common signature for favorable AML by Andreeff, M, Ruvolo, V, Gadgil, S, Zeng, C, Coombes, K, Chen, W, Kornblau, S, Barón, A E, Drabkin, H A

“…Deregulated HOX expression, by chromosomal translocations and myeloid-lymphoid leukemia (MLL) rearrangements, is causal in some types of leukemia. Using…”
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High-Throughput Tissue Microarray Analysis Used to Evaluate Biology and Prognostic Significance of the E-Cadherin Pathway in Non–Small-Cell Lung Cancer by BREMNES, R. M, VEVE, R, GABRIELSON, E, HIRSCH, F. R, BARON, A, BEMIS, L, GEMMILL, R. M, DRABKIN, H. A, FRANKLIN, W. A

“…E-cadherin (E-cad) and its associated intracellular molecules, catenins, are critical for intercellular epithelial adhesion and are often expressed in…”
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Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia by DRABKIN, H. A, PARSY, C, GEMMILL, R, BRIZARD, F, BRIZARD, A, ROCHE, J, FERGUSON, K, GUILHOT, F, LACOTTE, L, ROY, L, ZENG, C, BARON, A, HUNGER, S. P, VARELLA-GARCIA, M

“…We used a degenerate RT-PCR screen and subsequent real-time quantitative RT-PCR assays to examine the expression of HOX and TALE-family genes in 34 cases of…”
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A phase I study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer by Dasari, A., Gore, L., Messersmith, W. A., Diab, S., Jimeno, A., Weekes, C. D., Lewis, K. D., Drabkin, H. A., Flaig, T. W., Camidge, D. R.

“…Summary Background This phase I study evaluated the safety, tolerability and preliminary efficacy of sorafenib combined with vorinostat in patients with solid…”
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Mutations of the β- and γ-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas by UEDA, M, GEMMILL, R. M, WEST, J, WINN, R, SUGITA, M, TANAKA, N, UEKI, M, DRABKIN, H. A

“…Beta-catenin forms complexes with Tcf and Lef-1 and functions as a transcriptional activator in the Wnt signalling pathway. Although recent investigations have…”
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Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma by GEMMILL, R. M, ZHOU, M, COSTA, L, KORCH, C, BUKOWSKI, R. M, DRABKIN, H. A

“…Epidermal growth factor receptor (EGFR) and tumour growth factor alpha (TGFalpha) are frequently overexpressed in renal cell carcinoma (RCC) yet responses to…”
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RING-dependent tumor suppression and G2 M arrest induced by the TRC8 hereditary kidney cancer gene by BRAUWEILER, A, LORICK, K. L, LEE, J. P, TSAI, Y. C, CHAN, D, WEISSMAN, A. M, DRABKIN, H. A, GEMMILL, R. M

“…TRC8/RNF139 and von Hippel-Lindau (VHL) both encode E3 ubiquitin (Ub) ligases mutated in clear-cell renal carcinomas (ccRCC). VHL, inactivated in nearly 70% of…”
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Chromosome 3p14 Homozygous Deletions and Sequence Analysis of FRA3B by Boldog, Ferenc, Gemmill, Robert M., West, James, Robinson, Misi, Robinson, Linda, Li, Efang, Roche, Joelle, Todd, Sean, Waggoner, Barbara, Lundstrom, Ron, Jacobson, Jan, Mullokandov, Michael R., Klinger, Harold, Drabkin, Harry A.

“…Loss of heterozygosity (LOH) involving 3p occurs in many carcinomas but is complicated by the identification of four distinct homozygous deletion regions. One…”
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Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics by ROCHE, J, ZENG, C, BARON, A, GADGIL, S, GEMMILL, R. M, TIGAUD, I, THOMAS, X, DRABKIN, H. A

“…We previously reported that favorable and poor prognostic chromosomal rearrangements in acute myeloid leukemia (AML) were associated with distinct levels of…”
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The 3;21 Translocation in Myelodysplasia Results in a Fusion Transcript Between the AML1 Gene and the Gene for EAP, a Highly Conserved Protein Associated with the Epstein-Barr Virus Small RNA EBER 1 by Nucifora, Giuseppina, Begy, Catherine R., Erickson, Paul, Drabkin, Harry A., Rowley, Janet D.

“…In the 8;21 translocation, the AML1 gene, located at chromosome band 21q22, is translocated to chromosome 8 (q22), where it is fused to the ETO gene and…”
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An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation by DOWNING, J. R, HEAD, D. R, CIVIN, C. I, ERICKSON, P, CURCIO-BRINT, A. M, HULSHOF, M. G, MOTRONI, T. A, RAIMONDI, S. C, CARROLL, A. J, DRABKIN, H. A, WILLMAN, C, THEIL, K. S

“…The 8;21 translocation is one of the most common chromosomal translocations in acute myelogenous leukemia (AML), accounting for 40% of pediatric AML with…”
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Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting by VARELLA-GARCIA, M, HOGAN, C. J, MCGAVRAN, L, GEMMILL, R. M, BERGER, R, DRABKIN, H. A, ODOM, L. F, MURATA-COLLINS, I. L, AI, H, CHEN, L, RICHKIND, K, PASKULIN, G, ANDREEFF, M, BRIZARD, A

“…Many patients with t(8;21) AML have residual positive cells during remission. We previously developed D-FISH probes that detect both derivative chromosomes and…”
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Frequent loss of heterozygosity on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma by GREBE, S. K. G, MCIVER, B, HAY, I. D, WU, P. S.-C, MACIEL, L. M. Z, DRABKIN, H. A, GOELLNER, J. R, GRANT, C. S, JENKINS, R. B, EBERHARDT, N. L

“…Follicular thyroid carcinoma (FTC) exhibits frequent loss of heterozygosity (LOH) on chromosomes 10q and 3p, suggesting involvement of tumor suppressor genes…”
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ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors : Implications for t(8;21) leukemogenesis and monitoring residual disease by ERICKSON, P. F, DESSEV, G, LASHER, R. S, PHILIPS, G, ROBINSON, M, DRABKIN, H. A

“…To study acute myelogenous leukemia 1 (AML1) transcription factor, ETO protein, and t(8;21) AML chimeric AML1/ ETO protein in normal hematopoiesis and in…”
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Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21 by George, Jr, A L, Varkony, T A, Drabkin, H A, Han, J, Knops, J F, Finley, W H, Brown, G B, Ward, D C, Haas, M

“…The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent…”
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Detection of DNA Rearrangements in the AML1 and ETO Loci and of an AML1/ETO Fusion mRNA in Patients With t(8;21) Acute Myeloid Leukemia by Nucifora, Giuseppina, Birn, Debra J., Erickson, Paul, Gao, Jizong, LeBeau, Michelle M., Drabkin, Harry A., Rowley, Janet D.

“…The (8;21)(q22;q22) translocation is a frequent karyotypic abnormality seen in approximately 40% of patients with acute myeloid leukemia subtype M2 (AML-M2)…”
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Homozygous deletions of human chromosome 3p in lung tumors by TODD, S, FRANKLIN, W. A, VARELLA-GARCIA, M, KENNEDY, T, HILLIKER, C. E, HAHNER, L. JR, ANDERSON, M, WIEST, J. S, DRABKIN, H. A, GEMMILL, R. M

“…Cytogenetic and loss of heterozygosity (LOH) studies have demonstrated that deletions of chromosome 3p occur at a high frequency in all forms of lung cancer…”
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The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor by ERICKSON, P. F, ROBINSON, M, OWENS, G, DRABKIN, H. A

“…The 8;21 translocation, t(8;21)(q22;q22.3), is seen only in acute myelogenous leukemia and is characteristically associated with the M2 subtype. Subsequent to…”
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Positional Cloning of the Hereditary Renal Carcinoma 3;8 Chromosome Translocation Breakpoint by Boldog, Ferenc L., Gemmill, Robert M., Wilke, Charles M., Glover, Thomas W., Nilsson, Ann-Sofie, Chandrasekharappa, Settara C., Brown, Robert S., Li, Frederick P., Drabkin, Harry A.

“…The chromosome (p14.2;q24.1) translocation t(3;8)has been associated with hereditary renal cancer in one family. Based on cytogenetic analyses and…”
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DEF-3(G16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC by DRABKIN, H. A, WEST, J. D, HOTFILDER, M, HENG, Y. M, ERICKSON, P, CALVO, R, DALMAU, J, GEMMILL, R. M, SABLITZKY, F

“…DEF-3(g16/NY-LU-12) encodes a novel RNA binding protein isolated by positional cloning from an SCLC homozygous deletion region in 3p21.3 and, in parallel, as a…”
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