Search Results - "Dröge, Peter"

Versatile seamless DNA vector production in E. coli using enhanced phage lambda integrase by Roy, Suki, Peter, Sabrina, Dröge, Peter

“…Seamless DNA vectors derived from bacterial plasmids are devoid of bacterial genetic elements and represent attractive alternatives for biomedical applications…”
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Chromatin Architectural Factors as Safeguards against Excessive Supercoiling during DNA Replication by Ahmed, Syed Moiz, Dröge, Peter

“…Key DNA transactions, such as genome replication and transcription, rely on the speedy translocation of specialized protein complexes along a double-stranded,…”
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Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling by Zhao, Xiaodan, Peter, Sabrina, Dröge, Peter, Yan, Jie

“…HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich…”
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology by Ahmed, Syed Moiz, Dröge, Peter

“…Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2). Several…”
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Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT) by Kusuma, Frances Karla, Prabhu, Aishvaryaa, Tieo, Galen, Ahmed, Syed Moiz, Dakle, Pushkar, Yong, Wai Khang, Pathak, Elina, Madan, Vikas, Jiang, Yan Yi, Tam, Wai Leong, Kappei, Dennis, Dröge, Peter, Koeffler, H. Phillip, Jeitany, Maya

“…Alternative lengthening of telomeres (ALT) supports telomere maintenance in 10–15% of cancers, thus representing a compelling target for therapy. By performing…”
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Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility by Xing, Qiao Rui, Farran, Chadi A El, Zeng, Ying Ying, Yi, Yao, Warrier, Tushar, Gautam, Pradeep, Collins, James J, Xu, Jian, Dröge, Peter, Koh, Cheng-Gee, Li, Hu, Zhang, Li-Feng, Loh, Yuin-Han

“…Joint profiling of transcriptome and chromatin accessibility within single cells allows for the deconstruction of the complex relationship between…”
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Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity…”
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The FGFR inhibitor PD173074 binds to the C‐terminus of oncofetal HMGA2 and modulates its DNA‐binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

“…The architectural chromatin factor high‐mobility group AT‐hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not…”
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A non-viral genome editing platform for site-specific insertion of large transgenes by Chaudhari, Namrata, Rickard, Amanda M, Roy, Suki, Dröge, Peter, Makhija, Harshyaa

“…Abstract Background The precise, functional and safe insertion of large DNA payloads into host genomes offers versatility in downstream genetic…”
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The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity by Ahmed, Syed Moiz, Ramani, Priya Dharshana, Wong, Stephen Qi Rong, Zhao, Xiaodan, Ivanyi-Nagy, Roland, Leong, Tang Choong, Chua, Clarinda, Li, Zhizhong, Hentze, Hannes, Tan, Iain BeeHuat, Yan, Jie, DasGupta, Ramanuj, Dröge, Peter

“…The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases…”
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HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells by Natarajan, Suchitra, Hombach-Klonisch, Sabine, Dröge, Peter, Klonisch, Thomas

“…Abstract The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2) is expressed in stem cells and many cancer cells, including tumor…”
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The High Mobility Group Protein HMGA2: A Co-Regulator of Chromatin Structure and Pluripotency in Stem Cells? by Pfannkuche, Kurt, Summer, Heike, Li, Ou, Hescheler, Jürgen, Dröge, Peter

“…The small, chromatin-associated HMGA proteins contain three separate DNA binding domains, so-called AT hooks, which bind preferentially to short AT-rich…”
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The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis by Ivanyi-Nagy, Roland, Ahmed, Syed Moiz, Peter, Sabrina, Ramani, Priya Dharshana, Ong, Peh Fern, Dreesen, Oliver, Dröge, Peter

“…Telomerase RNA (TR) provides the template for DNA repeat synthesis at telomeres and is essential for genome stability in continuously dividing cells. We mapped…”
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Physical organization of DNA by multiple non-specific DNA-binding modes of integration host factor (IHF) by Lin, Jie, Chen, Hu, Dröge, Peter, Yan, Jie

“…The integration host factor (IHF) is an abundant nucleoid-associated protein and an essential co-factor for phage λ site-specific recombination and gene…”
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Site selectivity of platinum anticancer therapeutics by Davey, Curt A, Wu, Bin, Dröge, Peter

“…X-ray crystallographic and biochemical investigation of the reaction of cisplatin and oxaliplatin with nucleosome core particle and naked DNA reveals that…”
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DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells by Li, Ou, Li, Jinming, Dröge, Peter

“…The high-mobility group (HMG) protein A2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipogenesis,…”
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Alternate rRNA secondary structures as regulators of translation by Dröge, Peter, Feng, Shu, Li, Heng, Zhao, Jing, Pervushin, Konstantin, Lowenhaupt, Ky, Schwartz, Thomas U

“…Understanding the structural dynamics of ribosomal components is key to understanding translation. The Z-DNA– and Z-RNA–binding domain from the human RNA…”
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A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells by Siddiqui, Asim Azhar, Peter, Sabrina, Ngoh, Eve Zi Xian, Wang, Cheng-I, Ng, Shirelle, Dangerfield, John A, Gunzburg, Walter H, Dröge, Peter, Makhija, Harshyaa

“…Reliable cell-based platforms to test and/or produce biologics in a sustainable manner are important for the biotech industry. Utilizing enhanced λ integrase,…”
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Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents by Chua, Eugene Y D, Davey, Gabriela E, Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Davey, Curt A

“…Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been…”
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Conservative site-specific and single-copy transgenesis in human LINE-1 elements by Vijaya Chandra, Shree Harsha, Makhija, Harshyaa, Peter, Sabrina, Myint Wai, Cho Mar, Li, Jinming, Zhu, Jindong, Ren, Zhonglu, D'Alcontres, Martina Stagno, Siau, Jia Wei, Chee, Sharon, Ghadessy, Farid John, Dröge, Peter

“…Genome engineering of human cells plays an important role in biotechnology and molecular medicine. In particular, insertions of functional multi-transgene…”
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