Search Results - "Doze, P"

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier by Doze, P., Van Waarde, A., Elsinga, P.H., Hendrikse, N.H., Vaalburg, W.

“…Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P‐glycoprotein (P‐gp), an ATP‐driven drug efflux pump at the blood–brain barrier…”
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Synthesis and evaluation of radiolabeled antagonists for imaging of β-adrenoceptors in the brain with PET by Doze, P, Elsinga, P.H, Maas, B, Van Waarde, A, Wegman, T, Vaalburg, W

“…Five potent, lipophilic β-adrenoceptor antagonists (carvedilol, pindolol, toliprolol and fluorinated analogs of bupranolol and penbutolol) were labeled with…”
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362P Efficacy and safety of MCLA-129, an anti-EGFR/c-MET bispecific antibody, in head and neck squamous cell cancer (HNSCC) by Bossi, P., Minuti, G., Braña, I., Moreno Garcia, V., Boni, V., Jamme, P., Call, J.A., Yan, C., Barasa, B., Doze, P., Joe, A.K., Laus, G., Daste, A.

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Synthesis and evaluation of ( S)- [formula omitted]-fluoroethylcarazolol for in vivo β-adrenoceptor imaging in the brain by Doze, P., van Waarde, A., Tewson, T.J., Vaalburg, W., Elsinga, P.H.

“…The β-adrenergic receptor ligand ( S)-4-(3-(2′- [ 18 F] -fluoroethylamino)-2-hydroxypropoxy)-carbazol (( S)- [ 18 F] -fluoroethylcarazolol) was prepared by…”
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MCLA-129, a human anti-EGFR and anti-c-MET bispecific antibody, in patients with advanced NSCLC and other solid tumors: an ongoing phase 1/2 study by Ou, S.H., Moreno Garcia, V., Gil Bazo, I., Prenen, H., Moreno, I., Johnson, M., Castañón Álvarez, E., Nagasaka, M., Adeyemi, S., Barasa, B., Bol, K., Doze, P., Engbers, A., Joe, A.K., Stalbovskaya, V., Laus, G., Call, J.

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Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligand carazolol in the Ames test by Doze, P, Elsinga, P.H, de Vries, E.F.J, Van Waarde, A, Vaalburg, W

“…S-1′[ 18F]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagenic beta-blocker carazolol (CAR). In former studies FCAR proved to be suitable for…”
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Influence of P-glycoprotein on brain uptake of [ 18F]MPPF in rats by Passchier, Jan, van Waarde, Aren, Doze, Petra, Elsinga, Philip H, Vaalburg, Willem

“…The aim of this study was to determine if the brain uptake of 4-(2′-methoxyphenyl)-1-[2′-( N-2″-pyridinyl)- p-[ 18F]fluorobenzamido]ethylpiperazine ([…”
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PET imaging of beta-adrenoceptors in human brain: a realistic goal or a mirage? by van Waarde, Aren, Vaalburg, Willem, Doze, Petra, Bosker, Fokko J, Elsinga, Philip H

“…Beta-adrenoceptors are predominantly located in the cerebral cortex, nucleus accumbens and striatum. At lower densities, they are also present in amygdala,…”
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Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography by Hospers, G A, Calogero, A, van Waarde, A, Doze, P, Vaalburg, W, Mulder, N H, de Vries, E F

“…9-[(1-[18F]Fluoro-3-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) was evaluated as a tracer for noninvasive positron emission tomography (PET) imaging of herpes…”
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XLSSC 122 caught in the act of growing up: Spatially resolved SZ observations of a z=1.98 galaxy cluster by van Marrewijk, J, Di Mascolo, L, Gill, A. S, Battaglia, N, Battistelli, E. S, Bond, J. R, Devlin, M. J, Doze, P, Dunkley, J, Knowles, K, Hincks, A, Hughes, J. P, Hilton, M, Moodley, K, Mroczkowski, T, Naess, S, Partridge, B, Popping, G, Sifón, C, Staggs, S. T, Wollack, E. J

“…A&A 689, A41 (2024) How protoclusters evolved from sparse galaxy overdensities to mature galaxy clusters is still not well understood. In this context,…”
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Quantification of β-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model by DOZE, Petra, ELSINGA, Philip H, VAN WAARDE, Aren, PIETERMAN, Remge M, PRUIM, Jan, VAALBURG, Willem, WILLEMSEN, Antoon T. M

“…The aim of this study was to determine whether the beta-adrenoceptor receptor density (Bmax) and the ligand affinity (KD) of (S)-[11C]CGP 12388 for the…”
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Imaging of β-adrenoceptors in the human thorax using ( S)-[ 11C]CGP12388 and positron emission tomography by Elsinga, Philip H, Doze, Petra, van Waarde, Aren, Pieterman, Remge M, Blanksma, Paul K, Willemsen, Antoon T.M, Vaalburg, Willem

“…We report positron emission tomography studies of β-adrenoceptors in the human thorax with ( S)-[ 11C]CGP12388 (4-(3-(2′-[…”
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Characterisation of β2-adrenoceptors, using the agonist [11C]formoterol and positron emission tomography by VISSER, T. J, VAN WAARDE, A, DOZE, P, ELSINGA, P. H, VAN DER MARK, T. W, KRAAN, J, ENSING, K, VAALBURG, W

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A novel β-adrenoceptor ligand for positron emission tomography: Evaluation in experimental animals by van Waarde, Aren, Elsinga, Philip H, Doze, Petra, Heldoorn, Marco, Jaeggi, Knut A, Vaalburg, Willem

“…Myocardial and pulmonary β-adrenoceptors can be imaged and quantified with the antagonist (…”
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Synthesis and evaluation of radiolabelled antagonists for beta-adrenoceptor imaging in the brain with pet by Elsinga, P. H., Doze, P., Maas, B., Van Waarde, A., Wegman, T., Vaalburg, W.

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Preclinical testing of N-[11c]-methyl-piperidin-4-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate, a novel radioligand for detection of cerebral muscarinic receptors using PET by Visser, Thomas Jakob, Van Waarde, Aren, Doze, Petra, Wegman, Theodora, Vaalburg, Willem

“…The muscarinic antagonist N‐[11C]methyl‐piperidin‐4‐yl 2‐cyclohexyl‐2‐hydroxy‐2‐phenylacetate (VC‐004) 1 was tested for visualization of muscarinic receptors…”
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Validation of S-1′-[ [formula omitted]]fluorocarazolol for in vivo imaging and quantification of cerebral β-adrenoceptors by Doze, Petra, Van Waarde, Aren, Elsinga, Philip H, Van-Loenen Weemaes, Anne-Miek A, Willemsen, Antoon T.M, Vaalburg, Willem

“…S-1′-[ 18 F ]fluorocarazolol ( S-(−)-4-(2-hydroxy-3-(1′-[ 18 F ]fluoroisopropyl)-aminopropoxy)carbazole, a non-subtype-selective β-adrenoceptor antagonist) has…”
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Synthesis and biodistribution of [11c]procaterol, a beta2-adrenoceptor agonist for positron emission tomography by Visser, T J, van der Wouden, E A, van Waarde, A, Doze, P, Elsinga, P H, Vaalburg, W

“…The potent, subtype-selective radioligand (+/-)-erythro-5-(1-hydroxy-2-[11C]isopropyl-aminobutyl)-8-hydroxy-car bostyril ([11C]procaterol) was synthesized and…”
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Characterisation of beta2-adrenoceptors, using the agonist [11C]formoterol and positron emission tomography by Visser, T J, van Waarde, A, Doze, P, Elsinga, P H, van der Mark, T W, Kraan, J, Ensing, K, Vaalburg, W

“…The agonist radioligand N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-[11C]-methoxyphenyl)-1-methylethyl]am ino]ethyl]phenyl]formamide ([11C]formoterol) was synthesised…”
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Profiling Primary Protease Specificity by Peptide Synthesis on a Solid Support by Doezé, Ron H. P., Maltman, Beatrice A., Egan, Claire L., Ulijn, Rein V., Flitsch, Sabine L.

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