Search Results - "Doyle, V M"
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Regulation of Integrin Function by the Urokinase Receptor
Published in Science (American Association for the Advancement of Science) (13-09-1996)“…Integrin function is central to inflammation, immunity, and tumor progression. The urokinase-type plasminogen activator receptor (uPAR) and integrins formed…”
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Quantitation of mRNA by the Polymerase Chain Reaction
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-1989)“…A method for the quantitation of specific mRNA species by the polymerase chain reaction (PCR) has been developed by using a synthetic RNA as an internal…”
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High-Affinity Urokinase Receptor Antagonists Identified with Bacteriophage Peptide Display
Published in Proceedings of the National Academy of Sciences - PNAS (19-07-1994)“…Affinity selection of a 15-mer random peptide library displayed on bacteriophage M13 has been used to identify potent ligands for the human urokinase receptor,…”
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Semirational design of a potent, artificial agonist of fibroblast growth factor receptors
Published in Nature biotechnology (01-12-1999)“…Fibroblast growth factors (FGFs) are being investigated in human clinical trials as treatments for angina, claudication, and stroke. We designed a molecule…”
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Increased Apolipoprotein E and c-fms Gene Expression without Elevated Interleukin 1 or 6 mRNA Levels Indicates Selective Activation of Macrophage Functions in Advanced Human Atheroma
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-1992)“…Cells found within atherosclerotic lesions can produce in culture protein mediators that may participate in atherogenesis. To test whether human atheromata…”
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Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine
Published in Proceedings of the National Academy of Sciences - PNAS (01-06-1989)“…Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could…”
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Comparison of two algorithms and their associated charges when evaluating adrenal masses in patients with malignancies
Published in American journal of roentgenology (1976) (01-06-1997)“…This study was performed to compare two proposed algorithms used when evaluating an adrenal mass discovered during staging evaluation of a patient with a known…”
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Vasopressin induced production of inositol trisphosphate and calcium efflux in a smooth muscle cell line
Published in Biochemical and biophysical research communications (30-08-1985)“…Phosphatidylinositol metabolism and 45Ca2+ efflux were examined in a vascular smooth muscle cell line (A7r5). [Arg 8]Vasopressin stimulated the rapid formation…”
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Lack of evidence for voltage dependent calcium channels on platelets
Published in Biochemical and biophysical research communications (28-02-1985)“…Intracellular calcium was measured in human platelets using the fluorescent calcium indicator Quin 2. A concentration dependent increase was observed with…”
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Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT2 receptor in A7r5 smooth muscle cells
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-06-1986)“…Serotonin (5-HT) induces inositol phosphate production and the efflux of 45Ca2+ in a smooth muscle cell line (A7r5) derived from rat aorta. These effects were…”
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A smooth muscle cell line suitable for the study of voltage sensitive calcium channels
Published in Biochemical and biophysical research communications (16-07-1985)“…A cell line originating from the fetal rat aorta has been studied with respect to 45Ca2+ uptake. Kinetic experiments showed an initial rapid uptake followed by…”
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High level human interleukin 1 production by a hepatoma cell line
Published in Biochemical and biophysical research communications (31-07-1985)“…The human hepatic adenocarcinoma cell line, SK-hep-1, was found to constitutively produce Interleukin 1. Addition of the ionophore A23187 and…”
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Platelet-activating factor mobilises intracellular calcium in vascular smooth muscle cells
Published in FEBS letters (03-03-1986)“…The effect of platelet-activating factor (PAF) on polyphosphoinositide metabolism and 45Ca 2+ efflux was examined in a vascular smooth muscle cell line (A 7r…”
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Effects of calcium entry blockers on calcium fluxes in a vascular smooth muscle cell line
Published in Journal of hypertension. Supplement (01-12-1985)“…A smooth muscle cell line was used for studies on the activity of the voltage-sensitive calcium channel (VSCC). Upon exposure to a depolarizing solution or to…”
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Urokinase receptor antagonists: discovery and application to in vivo models of tumor growth
Published in APMIS : acta pathologica, microbiologica et immunologica Scandinavica (01-01-1999)“…Urokinase receptor antagonists based on the growth factor domains of both human and murine urokinase which show sub‐nanomolar affinities for their homologous…”
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Adult Literacy Education in Namibia
Published in Community development journal (01-04-1979)“…Presented is a quantitative & qualitative analysis of adult literacy education in Namibia. The very little that was found is described under four headings: the…”
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Susceptibility of newborn mice with H-2k backgrounds to lymphocytic choriomeningitis virus infection
Published in Immunology (01-08-1980)“…Many strains of mice, when injected at birth with an ordinarily lethal dose of lymphocytic choriomeningitis virus (LCMV), grow to adulthood despite maintaining…”
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Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection
Published in The Journal of immunology (1950) (01-02-1980)“…Mice of several strains persistently infected with lymphocytic choriomeningitis virus (LCMV) mount continuous anti-LCMV immune responses leading to the…”
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Effect of Lipopolysaccharide on Immunogenicity and Tolerogenicity of HGG in C57BL/6J Nude Mice: Evidence for a Possible B Cell Deficiency
Published in The Journal of immunology (1950) (01-12-1977)“…Abstract Studies were performed to define the in vivo and in vitro responsiveness of nude mice to bacterial lipopolysaccharide (LPS). The in vitro…”
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