Search Results - "Doyle, Sean E"

Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production by Chang, Elmer Y, Guo, Beichu, Doyle, Sean E, Cheng, Genhong

“…Macrophages respond to LPS by the rapid activation of proinflammatory cytokines that serve to initiate host defense against microbial invasion. To prevent…”
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Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo by Stifter, Sebastian A., Bhattacharyya, Nayan, Sawyer, Andrew J., Cootes, Taylor A., Stambas, John, Doyle, Sean E., Feigenbaum, Lionel, Paul, William E., Britton, Warwick J., Sher, Alan, Feng, Carl G.

“…Interferons (IFN) are pleiotropic cytokines essential for defense against infection, but the identity and tissue distribution of IFN-responsive cells in vivo…”
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The signaling adaptors and pathways activated by TNF superfamily by Dempsey, Paul W, Doyle, Sean E, He, Jeannie Q, Cheng, Genhong

“…Members of the TNF receptor superfamily play pivotal roles in numerous biological events in metazoan organisms. Ligand-mediated trimerization by corresponding…”
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Toll-like receptors induce a phagocytic gene program through p38 by Doyle, Sean E, O'Connell, Ryan M, Miranda, Gustavo A, Vaidya, Sagar A, Chow, Edward K, Liu, Philip T, Suzuki, Shinobu, Suzuki, Nobutaka, Modlin, Robert L, Yeh, Wen-Chen, Lane, Timothy F, Cheng, Genhong

“…Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the…”
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Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness by Galani, Ioanna E., Triantafyllia, Vasiliki, Eleminiadou, Evridiki-Evangelia, Koltsida, Ourania, Stavropoulos, Athanasios, Manioudaki, Maria, Thanos, Dimitris, Doyle, Sean E., Kotenko, Sergei V., Thanopoulou, Kalliopi, Andreakos, Evangelos

“…Lambda interferons (IFNλs) or type III IFNs share homology, expression patterns, signaling cascades, and antiviral functions with type I IFNs. This has…”
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Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes by DOYLE, Sean E, SCHRECKHISE, Heidi, CHAN, Chung, BIRKS, Carl, FOSTER, Don, CLEGG, Christopher H, WIETZKE-BRAUN, Perdita, MIHM, Sabine, KLUCHER, Kevin M, KHUU-DUONG, Kien, HENDERSON, Katherine, ROSLER, Robert, STOREY, Harold, LENA YAO, HONG LUI, BARAHMAND-POUR, Fariba, SIVAKUMAR, Pallavur

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Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier by Lazear, Helen M, Daniels, Brian P, Pinto, Amelia K, Huang, Albert C, Vick, Sarah C, Doyle, Sean E, Gale, Jr, Michael, Klein, Robyn S, Diamond, Michael S

“…Although interferon-λ [also known as type III interferon or interleukin-28 (IL-28)/IL-29] restricts infection by several viruses, its inhibitory mechanism has…”
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Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease by Chiriac, Mircea T, Buchen, Barbara, Wandersee, Alexandra, Hundorfean, Gheorghe, Günther, Claudia, Bourjau, Yvonne, Doyle, Sean E, Frey, Benjamin, Ekici, Arif B, Büttner, Christian, Weigmann, Benno, Atreya, Raja, Wirtz, Stefan, Becker, Christoph, Siebler, Jürgen, Neurath, Markus F

“…Background & Aims We investigated the roles of interleukin 28A (also called IL28A or interferon λ2) in intestinal epithelial cell (IEC) activation, studying…”
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IL‐28A (IFN‐λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease by Koltsida, Ourania, Hausding, Michael, Stavropoulos, Athanasios, Koch, Sonja, Tzelepis, George, Übel, Caroline, Kotenko, Sergei V., Sideras, Paschalis, Lehr, Hans A., Tepe, Marcus, Klucher, Kevin M., Doyle, Sean E., Neurath, Markus F., Finotto, Susetta, Andreakos, Evangelos

“…IL‐28 (IFN‐λ) cytokines exhibit potent antiviral and antitumor function but their full spectrum of activities remains largely unknown. Recently, IL‐28 cytokine…”
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Interleukin‐29 uses a type 1 interferon‐like program to promote antiviral responses in human hepatocytes by Doyle, Sean E., Schreckhise, Heidi, Khuu‐Duong, Kien, Henderson, Katherine, Rosler, Robert, Storey, Harold, Yao, Lena, Liu, Hong, Barahmand‐pour, Fariba, Sivakumar, Pallavur, Chan, Chung, Birks, Carl, Foster, Don, Clegg, Christopher H., Wietzke‐Braun, Perdita, Mihm, Sabine, Klucher, Kevin M.

“…Interleukin‐28A (IL‐28A), IL‐28B and IL‐29 are a family of class II cytokines that stimulate antiviral responses through a heterodimeric receptor that is…”
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Rescue of TRAF3-null mice by p100 NF-kappa B deficiency by He, Jeannie Q, Zarnegar, Brian, Oganesyan, Gagik, Saha, Supriya K, Yamazaki, Soh, Doyle, Sean E, Dempsey, Paul W, Cheng, Genhong

“…Proper activation of nuclear factor (NF)-kappaB transcription factors is critical in regulating fundamental biological processes such as cell survival and…”
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IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program by Doyle, Sean E., Vaidya, Sagar A., O'Connell, Ryan, Dadgostar, Hajir, Dempsey, Paul W., Wu, Ting-Ting, Rao, Govinda, Sun, Ren, Haberland, Margaret E., Modlin, Robert L., Cheng, Genhong

“…We have identified a subset of genes that is specifically induced by stimulation of TLR3 or TLR4 but not by TLR2 or TLR9. Further gene expression analyses…”
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Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4 by Doyle, Sean E, O'Connell, Ryan, Vaidya, Sagar A, Chow, Edward K, Yee, Kathleen, Cheng, Genhong

“…We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In…”
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T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK by Dadgostar, Hajir, Doyle, Sean E., Shahangian, Arash, Garcia, Daniel E., Cheng, Genhong

“…Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their…”
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Peginterferon Lambda-1a, a New Therapeutic for Hepatitis C Infection, from Bench to Clinic by Andersen, Henrik, Meyer, Jeff, Freeman, Jeremy, Doyle, Sean E, Klucher, Kevin, Miller, Dennis M, Hausman, Diana, Hillson, Jan L

“…Chronic infection with hepatitis C virus (HCV) is estimated to affect approximately 3% of the world's population and cause 350,000 deaths each year. For a…”
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T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK 1 by Dadgostar, Hajir, Doyle, Sean E., Shahangian, Arash, Garcia, Daniel E., Cheng, Genhong

“…Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)‐associated factor (TRAF) family members is important for regulating their…”
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Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5 by Doyle, S E, Gasson, J C

“…The high-affinity human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) consists of an alpha (GMRalpha) and a common beta (betac)…”
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Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5 by Doyle, Sean E., Gasson, Judith C.

“…The high-affinity human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) consists of an alpha (GMRα) and a common beta (βc) subunit…”
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Interleukin-29 Mediates Potent Anti-Tumor Activity in the RenCa Model of Renal Cell Carcinoma by Sivakumar, Pallavur V, Doyle, Sean E, Shiota, Faith, Yao, Lena, Storey, Harold, Khuu-Duong, Kien, Liu, Hong Y, Chan, Chung, Kindsvogel, Wayne, Klucher, Kevin M, Clegg, Christopher H

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