Search Results - "Doyle, Paul M."

Beta human chorionic gonadotropin (β-hCG) expression in pituitary adenomas: relationship to endocrine function and tumour recurrence by Doyle, Paul M, Thiryayi, Waziq A, Joshi, Abhijit, du Plessis, Daniel, Kearney, Tara, Gnanalingham, Kanna K

“…The β subunit of human chorionic gonadotropin (β-hCG) is a marker of malignancies. Recent studies have also reported its expression in pituitary adenomas,…”
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Stereoselective synthesis of non-proteinogenic amino acids by Bowler, Andrew N, Doyle, Paul M, Hitchcock, Peter B, Young, Douglas W

“…The lactam enolate of the protected pyroglutamic acid ester ( 1) has been shown to react with activated imines to yield optically pure derivatives of…”
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Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins by Davies, David E., Doyle, Paul M., Hill, Richard D., Young, Douglas W.

“…The (3 S,6 S,10 S)-7/5 bicyclic lactam 8 , designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser…”
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Synthesis of external β-turn templates by reaction of protected dehydroamino acids with cyclic enaminoesters by Berry, Jane M., Doyle, Paul M., Young, Douglas W.

“…Two external β-turn templates have been synthesised and one of them has been derivatised as a GLDV-tetrapeptide. In the course of the synthesis an interesting…”
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Synthesis of glutamate agonists and anatagonists by a ring switching strategy by Dinsmore, Andrew, Doyle, Paul M., Young, Douglas W.

“…Our ring switching strategy for synthesis of compounds with structural features consistent with activity at glutamate receptors has been modified to prepare…”
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Synthesis of an external β-turn based on the GLDV motif of cell adhesion proteins by Davies, David E., Doyle, Paul M., Farrant, R.Duncan, Hill, Richard D., Hitchcock, Peter B., Sanderson, Paul N., Young, Douglas W.

“…The (3 S,6 S,10 S)-7/5 bicyclic lactam 4 , designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser…”
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An interesting dichotomy in the cyclisation of exocyclic enamines with protected dehydroamino acids leading to different β-turn templates by Berry, Jane M., Doyle, Paul M., Young, Douglas W.

“…Two templates for the preparation of external β-turns have been synthesised. In the course of the synthetic studies an interesting dichotomy was observed in…”
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Extension of ring switching strategy to the glutamate antagonist 2-(pyrimidin-2,4-dione-5-ylmethyl)-(2 S)-glycine and related compounds with two chiral centres by Dinsmore, Andrew, Doyle, Paul M, Hitchcock, Peter B, Young, Douglas W

“…2-(Pyrimidin-2,4-dione-5-ylmethyl)-(2 S)-glycine 8 has been prepared by treatment of the pyroglutamate urea 12 with mild base, followed by deprotection in a…”
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Design, synthesis and structure of a zinc finger with an artificial β-turn by Viles, John H., Patel, Sunil U., Mitchell, John B.O., Moody, Claire M., Justice, David E., Uppenbrink, Julia, Doyle, Paul M., Harris, C.John, Sadler, Peter J., Thornton, Janet M.

“…We have incorporated a bicyclic β-turn mimetic (BTD; β-turn dipeptide) into a zinc finger, creating a zinc finger with an artificial β-turn. The designed…”
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Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin-43, an α-helical protein with over 50% sequence identity to an all-β protein by Jones, David T., Moody, Claire M., Uppenbrink, Julia, Viles, John H., Doyle, Paul M., Harris, C. John, Pearl, Laurence H., Sadler, Peter J., Thornton, Janet M.

“…In response to the Paracelsus Challenge (Rose and Creamer, Proteins, 19:1–3, 1994), we present here the design, synthesis, and characterization of a helical…”
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Multiple solution conformations of the integrin-binding cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-). Analysis of the (phi, psi) space available to cyclic pentapeptides by Viles, J H, Mitchell, J B, Gough, S L, Doyle, P M, Harris, C J, Sadler, P J, Thornton, J M

“…The aqueous solution structure of the cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-) has been determined by two-dimensional 1H-NMR spectroscopy, combined…”
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Multiple Solution Conformations of the Integrin‐Binding Cyclic Pentapeptide Cyclo(‐Ser‐d‐Leu‐Asp‐Val‐Pro‐) by Viles, John H., Mitchell, John B. O., Gough, Sharon L., Doyle, Paul M., Harris, C. John, Sadler, Peter J., Thornton, Janet M.

“…The aqueous solution structure of the cyclic pentapeptide cyclo(‐Ser‐d‐Leu‐Asp‐Val‐Pro‐) has been determined by two‐dimensional 1H‐NMR spectroscopy, combined…”
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Solution structure of a biologically active cyclic LDV peptide analogue containing a type II' beta-turn mimetic by Doyle, P M, Harris, J C, Moody, C M, Sadler, P J, Sims, M, Thornton, J M, Uppenbrink, J, Viles, J H

“…The solution structure of cyclo-[Gly-Leu-Asp-Val-BTD] (BTD = beta-turn dipeptide) has been determined by two-dimensional 1H-NMR (nuclear magnetic resonance)…”
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Peptides incorporating electrophilic glutamine analogues as potential transglutaminase inhibitors by Doyle, P M, Harris, C J, Carter, K R, Simpkin, D S, Bailey-Smith, P, Stone, D, Russell, L, Blackwell, G J

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