Search Results - "Doyle, Donald F"

Creation and Discovery of Ligand-Receptor Pairs for Transcriptional Control with Small Molecules by Schwimmer, Lauren J., Rohatgi, Priyanka, Azizi, Bahareh, Seley, Katherine L., Doyle, Donald F., Evans, Ronald M.

“…The nuclear receptor retinoid X receptor (RXR) is a ligand-activated transcription factor. To create receptors for a new ligand, a structure-based approach was…”
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Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule by Taylor, Jennifer L, Rohatgi, Priyanka, Spencer, H Trent, Doyle, Donald F, Azizi, Bahareh

“…Molecular switch systems that activate gene expression by a small molecule are effective technologies that are widely used in applied biological research…”
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Histone Deacetylase Inhibitors Equipped with Estrogen Receptor Modulation Activity by Gryder, Berkley E, Rood, Michael K, Johnson, Kenyetta A, Patil, Vishal, Raftery, Eric D, Yao, Li-Pan D, Rice, Marcie, Azizi, Bahareh, Doyle, Donald F, Oyelere, Adegboyega K

“…We describe a set of novel histone deacetylase inhibitors (HDACi) equipped with either an antagonist or an agonist of the estrogen receptor (ER) to confer…”
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ESPSearch: a program for finding exact sequences and patterns in DNA, RNA, or protein by Watt, Terry J, Doyle, Donald F

“…ESPSearch is a computer program for rapidly identifying nucleic acid or amino acid sequences of any length within any source sequence from promoters to entire…”
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A human vitamin D receptor mutant activated by cholecalciferol by Ousley, Amanda M., Castillo, Hilda S., Duraj-Thatte, Anna, Doyle, Donald F., Azizi, Bahareh

“…► Engineering of a nuclear receptor to bind a novel small molecule. ► The role of histidine 305 in the human vitamin D receptor ligand binding pocket. ►…”
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Inhibition of Gene Expression Inside Cells by Peptide Nucleic Acids:  Effect of mRNA Target Sequence, Mismatched Bases, and PNA Length by Doyle, Donald F, Braasch, Dwaine A, Janowski, Bethany A, Corey, David R

“…Genome sequencing has revealed thousands of novel genes, placing renewed emphasis on chemical approaches for controlling gene expression. Antisense oligomers…”
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Chemical complementation: small-molecule-based genetic selection in yeast by Azizi, Bahareh, Chang, Eileen I, Doyle, Donald F

“…Protein and metabolic engineering would greatly benefit from a general system linking the presence of a small molecule to the power of genetic selection. We…”
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Engineering Orthogonal Ligand−Receptor Pairs from “Near Drugs” by Doyle, Donald F, Braasch, Dwaine A, Jackson, Laurie K, Weiss, Harald E, Boehm, Marcus F, Mangelsdorf, David J, Corey, David R

“…Cell-permeable small molecules are powerful tools for unraveling complex cellular pathways. We demonstrate that nuclear hormone receptors can be engineered…”
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Searching for quantitative entropy‐enthalpy compensation among protein variants by Beasley, James R., Doyle, Donald F., Chen, Lixin, Cohen, David S., Fine, Bryan R., Pielak, Gary J.

“…Entropy‐enthalpy (SH) compensation occurs when a small change in ΔG is caused by large, and nearly compensatory, changes in ΔH and ΔS. It is considered a…”
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Modifying ligand specificity of gene regulatory proteins by Doyle, Donald F, Mangelsdorf, David J, Corey, David R

“…Nuclear receptors contain a conserved hydrophobic ligand binding pocket that is particularly amenable to structure-based protein engineering. Thus,…”
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Unusual Effects of an Engineered Disulfide on Global and Local Protein Stability by Betz, Stephen F, Marmorino, Jennifer L, Saunders, Aleister J, Doyle, Donald F, Young, Gregory B, Pielak, Gary J

“…The global and local stabilities of a eukaryotic ferricytochrome c variant with an engineered disulfide are examined. The disulfide connects position 20, which…”
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Protein thermal denaturation, side-chain models, and evolution: amino acid substitutions at a conserved helix-helix interface by Pielak, Gary J, Auld, Douglas S, Beasley, James R, Betz, Stephen F, Cohen, David S, Doyle, Donald F, Finger, Shelley A, Fredericks, Zoey L, Hilgen-Willis, Sharon

“…Random mutant libraries with substitutions at the interface between the N- and C-terminal helices of Saccharomyces cerevisiae iso-1-cytochrome c were screened…”
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Amide proton exchange rates of oxidized and reduced saccharomyces cerevisiae iso‐1‐cytochrome c by Marmorino, Jennifer L., Auld, Douglas S., Betz, Stephen F., Doyle, Donald F., Young, Gregory B., Pielak, Gary J.

“…Proton NMR spectroscopy was used to determine the rate constant, kobs, for exchange of labile protons in both oxidized (Fe(III)) and reduced (Fe(II))…”
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Changing the Transition State for Protein (Un)folding by Doyle, Donald F, Waldner, Jennifer C, Parikh, Sudip, Alcazar-Roman, Luis, Pielak, Gary J

“…(Un)folding transition states of Saccharomyces cerevisiae iso-1-ferri- and ferrocytochromes c were studied using equilibrium and kinetic denaturation…”
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Probing weakly polar interactions in cytochrome c by Auld, Douglas S., Young, Gregory B., Saunders, Aleister J., Doyle, Donald F., Betz, Stephen F., Pielak, Gary J.

“…Theoretical, statistical, and model studies suggest that proteins are stabilized by weakly polar attractions between sulfur atoms and properly oriented…”
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Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR by Peet, Daniel J., Doyle, Donald F., Corey, David R., Mangelsdorf, David J.

“…Background: The retinoid X receptor (RXR) activates transcription of target genes in response to its natural ligand, 9- cis retinoic acid (9cRA), and a number…”
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Engineering proteins: keeping up with biology by Doyle, Donald F., Corey, David R.

“…A wide range of biological laboratories have adopted protein engineering techniques, altering the way biochemical research is carried out. Ironically, this…”
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Getriebeteile und Bodenroller in einer Anlage reinigen by Baier, Roland

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