A review of advances in the use of the GnRH agonist deslorelin in control of reproduction

A review of advances in the use of the GnRH agonist deslorelin in control of reproduction

The prevention of breeding in animals using GnRH analogues has been the object of research over many years. Recently, a new drug delivery formulation was developed which enabled the development of products that could be commercialised for veterinary use. The formulation has now been approved in cert...

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Bibliographic Details
Published in:Theriogenology Vol. 66; no. 6; pp. 1507 - 1512
Main Authors: Trigg, T.E., Doyle, A.G., Walsh, J.D., Swangchan-uthai, T.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-10-2006
Subjects:
anestrus
animal age
Animals
antifertility effect
Contraception
Contraceptive Agents - pharmacology
Dogs
Dogs - physiology
drug delivery systems
Drug Implants
Estrus - drug effects
Estrus - physiology
Female
females
GnRH analogues
gonadotropin-releasing hormone
hormone agonists
Induced estrus control
Male
males
Reproduction - drug effects
Testosterone - blood
Triptorelin Pamoate - analogs & derivatives
Triptorelin Pamoate - pharmacology
young animals
Contraception
GnRH analogues
Induced estrus control
Dogs
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Summary:The prevention of breeding in animals using GnRH analogues has been the object of research over many years. Recently, a new drug delivery formulation was developed which enabled the development of products that could be commercialised for veterinary use. The formulation has now been approved in certain countries for use in male dogs, and applications are being expanded to cover repeat usage, extended duration, use in females, other indications and other animal species. With respect to repeat usage, dogs have been re-implanted for four consecutive doses and monitored until they returned to normal steroidogenesis. All dogs returned to normal steroidogenesis following cessation of treatment. In females, it was previously shown that implanted bitches with progesterone <5 ng/mL at the time of implantation had an induced estrus. In a new study at Chulalongkorn University, implanting female pups at around 4 mo prevented this occurrence, whereas implantation at 7 mo did not.
Bibliography:http://dx.doi.org/10.1016/j.theriogenology.2006.02.037
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2006.02.037