Search Results - "Doyen, Noelle"

TLR9-Dependent Activation of Dendritic Cells by DNA from Leishmania major Favors Th1 Cell Development and the Resolution of Lesions by Hkima Abou Fakher, Faihaa, Rachinel, Nicolas, Klimczak, Martine, Louis, Jacques, Doyen, Noelle

“…In its vertebrate host, Leishmania encounters cells that express TLRs. Using genetically resistant C57BL/6 mice deficient in either TLR2, 4, or 9, we show in…”
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Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice by Guillerey, Camille, Mouriès, Juliette, Polo, Giulia, Doyen, Noelle, Law, Helen K.W., Chan, Susan, Kastner, Philippe, Leclerc, Claude, Dadaglio, Gilles

“…The physiologic role played by plasmacytoid dendritic cells (pDCs) in the induction of innate responses and inflammation in response to pathogen signaling is…”
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Response to Comment on “TLR9-Dependent Activation of Dendritic Cells by DNA from Leishmania major Favors Th1 Cell Development and the Resolution of Lesions” by Doyen, Noëlle

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Identification of a new cis-regulatory element of the terminal deoxynucleotidyl transferase gene in the 5′ region of the murine locus by Cherrier, Marie, D’Andon, Martine Fanton, Rougeon, François, Doyen, Noëlle

“…Terminal deoxynucleotidyl transferase (TdT) expression is controlled at the transcriptional level, however, the TdT core promoter combining D, D′, an initiator…”
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Evidence That the Long Murine Terminal Deoxynucleotidyltransferase Isoform Plays No Role in the Control of V(D)J Junctional Diversity by Doyen, Noelle, Boule, Jean-Baptiste, Rougeon, Francois, Papanicolaou, Catherine

“…Two TdT isoforms have been found in the mouse. The short isoform is known to add N regions to gene segment junctions during V(D)J recombination, but the role…”
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Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner by Rasid, Orhan, Mériaux, Véronique, Khan, Erin M, Borde, Chloé, Ciulean, Ioana S, Fitting, Catherine, Manoury, Bénédicte, Cavaillon, Jean-Marc, Doyen, Noëlle

“…A critical role for intracellular TLR9 has been described in recognition and host resistance to Leishmania parasites. As TLR9 requires endolysosomal…”
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LACK‐reactive CD4+ T cells require autocrine IL‐2 to mediate susceptibility to Leishmania major by Gumy, Alain, Aseffa, Abraham, Rachinel, Nicolas, Breton, Melanie, Otten, Luc, Tacchini‐Cottier, Fabienne, Röcken, Martin, Doyen, Noelle, Acha‐Orbea, Hans, Locksley, Richard M., MacDonald, H. Robson, Launois, Pascal, Louis, Jacques

“…Mice from most inbred strains are resistant to infection with Leishmania major whereas mice from BALB strains are highly susceptible. Resistance and…”
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A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype by BADIE, C, GOODHARDT, M, ARLETT, C. F, MALAISE, E.-P, WAUGH, A, DOYEN, N, FORAY, N, CALSOU, P, SINGLETON, B, GELL, D, SALLES, B, JEGGO, P

“…The 180BR cell line was derived from an acute lymphoblastic leukemia patient who overresponded to radiation therapy and died following radiation morbidity…”
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TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA by Khan, Mélissa Erin, Borde, Chloé, Rocha, Eduardo P C, Mériaux, Véronique, Maréchal, Vincent, Escoll, Pedro, Goyard, Sophie, Cavaillon, Jean-Marc, Manoury, Bénédicte, Doyen, Noëlle

“…DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially…”
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Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice by Rasid, Orhan, Ciulean, Ioana Sonya, Fitting, Catherine, Doyen, Noelle, Cavaillon, Jean-Marc

“…Systemic inflammatory response syndrome is a whole-body reaction to a triggering insult that often results in life-threatening illness. Contributing to the…”
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Extensive Junctional Diversity of Ig Heavy Chain Rearrangements Generated in the Progeny of Single Fetal Multipotent Hematopoietic Cells in the Absence of Selection by Nourrit, Francoise, Doyen, Noelle, Kourilsky, Philippe, Rougeon, Francois, Cumano, Ana

“…We analyzed the progeny of individual multipotent hemopoietic cells, derived from the para-aortic splanchopleura, the earliest identified source of lymphocyte…”
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Three Lymphoid-Specific Factors Account for all Junctional Diversity Characteristic of Somatic Assembly of T-Cell Receptor and Immunoglobulin Genes by Kallenbach, Sacha, Doyen, Noelle, d'Andon, Martine Fanton, Rougeon, Francois

“…The somatic diversity immunoglobulin and T-cell receptor diversity is largely provided by the junctional variation created during site-specific rearrangement…”
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TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages by Pandey, Surya Prakash, Doyen, Noelle, Mishra, Gyan C., Saha, Bhaskar, Chandel, Himanshu Singh

“…•We compare different TLRs expression in TLR2- or TLR9-deficient macrophages.•TLR9-deficient macrophages had reduced TLR1, TLR2, TLR3 expressions.•TLR2 did not…”
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Cytokine and iNOS profiles in lymph nodes of dogs naturally infected with Leishmania infantum and their association with the parasitic DNA load and clinical and histopathological features by de Vasconcelos, Tassia Cristina Bello, Doyen, Noelle, Cavaillon, Jean-Marc, Bruno, Sávio Freire, de Campos, Monique Paiva, de Miranda, Luisa Helena Monteiro, Madeira, Maria de Fátima, Belo, Vinícius Silva, Figueiredo, Fabiano Borges

“…•We evaluated dogs naturally infected with Leishmania infantum.•We showed their clinical status and their lymph node histopathological profile.•We studied…”
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TLR–CD40 Cross-Talk in Anti-Leishmanial Immune Response by Chandel, Himanshu Singh, Pandey, Surya Prakash, Roy, Sayoni, Doyen, Noelle, Saha, Bhaskar

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TLR-CD40 Cross-Talk in Anti-Leishmanial Immune Response by Chandel, Himanshu Singh, Pandey, Surya Prakash, Roy, Sayoni, Doyen, Noelle, Saha, Bhaskar

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Extensive junctional diversity in Ig light chain genes from early B cell progenitors of mu MT mice by Bentolila, L A, Olson, S, Marshall, A, Rougeon, F, Paige, C J, Doyen, N, Wu, G E

“…Nontemplated (N) nucleotide additions contribute significantly to the junctional diversity of all Ag receptor chains in adult mice except Ig light (L) chains,…”
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LACK-reactive CD4 super(+) T cells require autocrine IL-2 to mediate susceptibility to Leishmania major by Gumy, Alain, Aseffa, Abraham, Rachinel, Nicolas, Breton, Melanie, Otten, Luc, Tacchini-Cottier, Fabienne, Roecken, Martin, Doyen, Noelle, Acha-Orbea, Hans, Locksley, Richard M, MacDonald, HRobson, Launois, Pascal, Louis, Jacques

“…Mice from most inbred strains are resistant to infection with Leishmania major whereas mice from BALB strains are highly susceptible. Resistance and…”
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Cathepsin B-Deficient Mice Resolve Leishmania major Inflammation Faster in a T Cell-Dependent Manner by Rasid, Orhan, Mériaux, Véronique, Khan, Erin M, Borde, Chloé, Ciulean, Ioana S, Fitting, Catherine, Manoury, Bénédicte, Cavaillon, Jean-Marc, Doyen, Noëlle

“…A critical role for intracellular TLR9 has been described in recognition and host resistance to Leishmania parasites. As TLR9 requires endolysosomal…”
Get full text

TLR9 Activation Is Triggered by the Excess of Stimulatory versus Inhibitory Motifs Present in Trypanosomatidae DNA: e3308 by Khan, Mélissa Erin, Borde, Chloé, Rocha, Eduardo PC, Mériaux, Véronique, Maréchal, Vincent, Escoll, Pedro, Goyard, Sophie, Cavaillon, Jean-Marc, Manoury, Bénédicte, Doyen, Noëlle

“…DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially…”
Get full text