Search Results - "Doyen, J."

Late toxicities and clinical outcome at 5 years of the ACCORD 12/0405-PRODIGE 02 trial comparing two neoadjuvant chemoradiotherapy regimens for intermediate-risk rectal cancer by Azria, D., Doyen, J., Jarlier, M., Martel-Lafay, I., Hennequin, C., Etienne, P., Vendrely, V., François, E., de La Roche, G., Bouché, O., Mirabel, X., Denis, B., Mineur, L., Berdah, J., Mahé, M., Bécouarn, Y., Dupuis, O., Lledo, G., Seitz, J., Bedenne, L., Gourgou-Bourgade, S., Juzyna, B., Conroy, T., Gérard, J.

“…Outcome of intermediate risk rectal cancer may be improved by the addition of oxaliplatin during 5-fluoruracil concomitant neoadjuvant chemoradiotherapy. The…”
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MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines by Grosso, S, Doyen, J, Parks, S K, Bertero, T, Paye, A, Cardinaud, B, Gounon, P, Lacas-Gervais, S, Noël, A, Pouysségur, J, Barbry, P, Mazure, N M, Mari, B

“…The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of…”
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Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome by Doyen, J., Trastour, C., Ettore, F., Peyrottes, I., Toussant, N., Gal, J., Ilc, K., Roux, D., Parks, S.K., Ferrero, J.M., Pouysségur, J.

“…•Glycolytic markers are highly expressed in triple negative breast cancers.•Lactate/H+ symporter MCT4 demonstrated the strongest deleterious impact on…”
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Modulation of Type 5 Metabotropic Glutamate Receptor-Mediated Intracellular Calcium Mobilization by Regulator of G Protein Signaling 4 (RGS4) in Cultured Astrocytes by Beckers, Pauline, Doyen, Pierre J, Hermans, Emmanuel

“…Acting as GTPase activating proteins promoting the silencing of activated G-proteins, regulators of G protein signaling (RGSs) are generally considered…”
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Prognostic factors in 1038 women with metastatic breast cancer by Largillier, R., Ferrero, J.-M., Doyen, J., Barriere, J., Namer, M., Mari, V., Courdi, A., Hannoun-Levi, J. M., Ettore, F., Birtwisle-Peyrottes, I., Balu-Maestro, C., Marcy, P. Y., Raoust, I., Lallement, M., Chamorey, E.

“…Background: Treatment of metastatic breast cancer (MBC) remains palliative. Patients with MBC represent a heterogeneous group whose prognosis and outcome may…”
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Discontinuous stereotactic body radiotherapy schedule increases overall survival in early-stage non-small cell lung cancer by Duvergé, L., Bondiau, P.-Y., Claude, L., Supiot, S., Vaugier, L., Thillays, F., Doyen, J., Ricordel, C., Léna, H., Bellec, J., Chajon, E., de Crevoisier, R., Castelli, J.

“…•Aim: To evaluate the benefit of discontinuous SBRT schedule on local control (LC) and overall survival (OS) in NSCLC patients.•Results: OS and LC were…”
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Combining Stereotactic Radiotherapy and Conventional Radiotherapy for Peripheral Locally Advanced Lung Cancer by Boutros, J., Martin, N., Otto, J., Marquette, C.-H., Lhomel, B., Naghavi, A.O., Schiappa, R., Bondiau, P.-Y., Doyen, J.

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Aromatase inhibition in male breast cancer patients: biological and clinical implications by Doyen, J., Italiano, A., Largillier, R., Ferrero, J.-M., Fontana, X., Thyss, A.

“…The role of aromatase inhibitors (AIs) and their impact on estradiol (E2) levels remain unknown in male breast cancer (MBC) patients. MBC patients with…”
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Inflammation-associated regulation of RGS in astrocytes and putative implication in neuropathic pain by Doyen, Pierre J, Vergouts, Maxime, Pochet, Amandine, Desmet, Nathalie, van Neerven, Sabien, Brook, Gary, Hermans, Emmanuel

“…Regulators of G-protein signaling (RGS) are major physiological modulators of G-protein-coupled receptors (GPCR) signaling. Several GPCRs expressed in both…”
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Effects of proton versus photon irradiation on (lymph)angiogenic, inflammatory, proliferative and anti-tumor immune responses in head and neck squamous cell carcinoma by Lupu-Plesu, M, Claren, A, Martial, S, N'Diaye, P-D, Lebrigand, K, Pons, N, Ambrosetti, D, Peyrottes, I, Feuillade, J, Hérault, J, Dufies, M, Doyen, J, Pagès, G

“…The proximity of organs at risk makes the treatment of head and neck squamous cell carcinoma (HNSCC) challenging by standard radiotherapy. The higher precision…”
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‘Folfirinox’ chemotherapy combined with contact x-ray brachytherapy 50kVp and ‘CAP50’ chemoradiotherapy aiming at organ preservation for selected intermediate distal-middle cT2-T3 rectal cancers: A feasibility study by Mitrea, D., Barbet, N., Pacé-Loscos, T., Scouarnec, C., Ben-Dhia, S., Baron, D., Mineur, L., Évesque, L., Durand-Labrunie, J., Gérard, J.-P., Baudin, G., Doyen, J.

“…The standard treatment of T2–T3 rectal adenocarcinoma is radical proctectomy by total mesorectal excision often combined with some neoadjuvant treatment. To…”
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Patients’ needs in proton therapy: A survey among ten European facilities by Mazzola, G.C., Bergamaschi, L., Pedone, C., Vincini, M.G., Pepa, M., Zaffaroni, M., Volpe, S., Rombi, B., Doyen, J., Fossati, P., Haustermans, K., Høyer, M., Langendijk, J.A., Matute, R., Orlandi, E., Rylander, H., Troost, E.G.C., Orecchia, R., Alterio, D., Jereczek-Fossa, B.A.

“…•Proton therapy (PT) is a resource-limited approach due to the low number of available PT facilities.•Aim is to investigate logistic/economic support…”
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Role of proton therapy in reirradiation and in the treatment of sarcomas by Doyen, J., Aloi, D., Groulier, A., Vidal, M., Lesueur, P., Calugaru, V., Bondiau, P.Y.

“…Reirradiation and irradiation of sarcoma is often difficult due to the frequent need for a high dose of radiation in order to increase tumor control. This can…”
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Radiotherapy for primary tumor in lung cancer with synchronous metastases: Overview from the past and proposal for the future by Laurent, P.-A., Martin, E., Thariat, J., Doyen, J.

“…The management of metastatic lung cancers, either of the small-cell (SCLC) or the non-small cell (NSCLC) subtype, largely based on systemic treatments so far,…”
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Contact X-ray brachytherapy for rectal cancer: Past, present, and future by Gérard, J.-P., Barbet, N., Dejean, C., Montagne, L., Bénézery, K., Coquard, R., Doyen, J., Durand Labrunie, J., Hannoun-Lévi, J.-M.

“…The Papillon experience and the Lyon R96-02 trial have shown that contact X-ray brachytherapy of 50kV is efficient and safe to achieve long term local control…”
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Impact of radiotherapy schedule on survival of patients treated with immune-checkpoint inhibitors for advanced melanoma and non-small cell lung cancer by Sumodhee, S., Guo, L., Bouhlel, L., Picard, A., Otto, J., Naghavi, A.O., Richier, Q., Lévy, A., Bondiau, P.-Y., Poudenx, M., Passeron, T., Lacour, J.-P., Montaudié, H., Doyen, J.

“…Preclinical and clinical data suggest a potential benefit in the addition of radiotherapy (RT) to immune-checkpoint inhibitors (ICI) during the treatment of…”
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Stereotactic Pelvic Reirradiation for Locoregional Cancer Relapse by Kinj, R., Doyen, J., Hannoun-Lévi, J.M., Naghavi, A.O., Chand, M.E., Baudin, G., Ferrero, J.M., François, E., Evesque, L., Borchiellini, D., Benezery, K., Bondiau, P.Y.

“…Up to 40% of patients who have received radiation for a pelvic malignancy will develop locoregional recurrence in the previously irradiated volume…”
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Behavioural Assays to Model Cognitive and Affective Dimensions of Depression and Anxiety in Rats by Lapiz-Bluhm, M. D. S., Bondi, C. O., Doyen, J., Rodriguez, G. A., Bédard-Arana, T., Morilak, D. A.

“…Animal models have been used extensively to investigate neuropsychiatric disorders, such as depression, and their treatment. However, the aetiology and…”
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Organ Preservation for Early Rectal Cancer: The Role of Contact X-ray Brachytherapy 50 Kv (CXB) by Doyen, J, Benezery, K, Chapet, O, Hannoun-Levi, J.M, Gerard, J.P

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Pathological Response Is a Marker But Not a Cause of Good Prognosis in Rectal Cancer: 15-year Follow-up of the Lyon R90-01 Randomized Trial by Gerard, J.P, Cotte, E, Decullier, E, Doyen, J, Hannoun-Levi, J.M, Chapet, O

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