Search Results - "Dowzell, Kimberley"

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A genome-wide association study for late-onset Alzheimer's disease using DNA pooling by Abraham, Richard, Moskvina, Valentina, Sims, Rebecca, Hollingworth, Paul, Morgan, Angharad, Georgieva, Lyudmila, Dowzell, Kimberley, Cichon, Sven, Hillmer, Axel M, O'Donovan, Michael C, Williams, Julie, Owen, Michael J, Kirov, George

Published in BMC medical genomics (29-09-2008)

“…Late-onset Alzheimer's disease (LOAD) is an age related neurodegenerative disease with a high prevalence that places major demands on healthcare resources in…”
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease by Deloukas, Panagiotis, Hamshere, Marian L, Lovestone, Simon, Mead, Simon, Nöthen, Markus M, Gerrish, Amy, O'Donovan, Michael, Hüll, Michael, Hardy, John, Hampel, Harald, Passmore, Peter A, Engelborghs, Sebastiaan, Abraham, Richard, Thomas, Charlene, Moskvina, Valentina, Brayne, Carol, Lawlor, Brian, Bass, Nicholas J, McQuillin, Andrew, Holmans, Peter A, Jones, Nicola, Pahwa, Jaspreet Singh, Morgan, Kevin, Klopp, Norman, Schürmann, Britta, Carrasquillo, Minerva M, Jessen, Frank, Tsolaki, Magda, McGuinness, Bernadette, Van Broeckhoven, Christine, De Deyn, Peter P, Cruchaga, Carlos, Mayo, Kevin, Wichmann, H-Erich, Brown, Kristelle S, Fox, Nick, Proitsi, Petroula, Mühleisen, Thomas W, Lupton, Michelle K, Lynch, Aoibhinn, Williams, Julie, Singleton, Andrew B, Moebus, Susanne, Dowzell, Kimberley, Livingston, Gill, Powell, John, Todd, Stephen, Wiltfang, Jens, Kornhuber, Johannes, Shaw, Christopher E, Pankratz, V Shane, Owen, Michael J, Holmes, Clive, Kehoe, Patrick G, Al-Chalabi, Ammar, Morgan, Angharad R, Heuser, Isabella, Williams, Amy, Mann, David, Gurling, Hugh, Kauwe, John S K, Goate, Alison M, Frölich, Lutz, Rubinsztein, David C, Love, Seth, Rossor, Martin, Rujescu, Dan, Hollingworth, Paul, Bettens, Karolien, Younkin, Steven G, Nowotny, Petra, Dichgans, Martin, Smith, A David, Collinge, John, van den Bussche, Hendrik, Gwilliam, Rhian, Guerreiro, Rita, Jöckel, Karl-Heinz, Sims, Rebecca, Morris, John C, Gill, Michael, Craig, David, Sleegers, Kristel, Harold, Denise, Stretton, Alexandra, Maier, Wolfgang

Published in Nature genetics (01-10-2009)

“…We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date…”
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Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis by Proitsi, Petroula, Lupton, Michelle K, Velayudhan, Latha, Newhouse, Stephen, Fogh, Isabella, Tsolaki, Magda, Daniilidou, Makrina, Pritchard, Megan, Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Vellas, Bruno, Williams, Julie, Stewart, Robert, Sham, Pak, Lovestone, Simon, Powell, John F

Published in PLoS medicine (01-09-2014)

“…Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and…”
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Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins by Hosp, Fabian, Vossfeldt, Hannes, Heinig, Matthias, Vasiljevic, Djordje, Arumughan, Anup, Wyler, Emanuel, Landthaler, Markus, Hubner, Norbert, Wanker, Erich E., Lannfelt, Lars, Ingelsson, Martin, Lalowski, Maciej, Voigt, Aaron, Selbach, Matthias

Published in Cell reports (Cambridge) (19-05-2015)

“…Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative…”
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Four Components Describe Behavioral Symptoms in 1,120 Individuals with Late-Onset Alzheimer's Disease by Hollingworth, Paul, Hamshere, Marian L., Moskvina, Valentina, Dowzell, Kimberley, Moore, Pamela J., Foy, Catherine, Archer, Nicola, Lynch, Aoibhinn, Lovestone, Simon, Brayne, Carol, Rubinsztein, David C., Lawlor, Brian, Gill, Mike, Owen, Michael J., Williams, Julie

Published in Journal of the American Geriatrics Society (JAGS) (01-09-2006)

“…OBJECTIVES: To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity,…”
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The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease by Gerrish, Amy, Russo, Giancarlo, Richards, Alexander, Moskvina, Valentina, Ivanov, Dobril, Harold, Denise, Sims, Rebecca, Abraham, Richard, Hollingworth, Paul, Chapman, Jade, Hamshere, Marian, Pahwa, Jaspreet Singh, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad R, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter A, Craig, David, McGuinness, Bernadette, Todd, Stephen, Johnston, Janet A, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Kölsch, Heike, Heun, Reinhard, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M, Kauwe, John S K, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Davies, Gail, Harris, Sarah E, Starr, John M, Deary, Ian J, Al-Chalabi, Ammar, Shaw, Christopher E, Tsolaki, Magda, Singleton, Andrew B, Guerreiro, Rita, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V Shane, Younkin, Steven G, Jones, Lesley, Holmans, Peter A, O'Donovan, Michael C, Owen, Michael J, Williams, Julie

Published in Journal of Alzheimer's disease (01-01-2012)

“…Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of…”
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No consistent evidence for association between mtDNA variants and Alzheimer disease by HUDSON, G, SIMS, R, THOMAS, C, STRETTON, A, HOLMANS, P. A, O'DONOVAN, M. C, OWEN, M. J, WILLIAMS, J, CHINNER, P. F, HAROLD, D, CHAPMAN, J, HOLLINGWORTH, P, GERRISH, A, RUSSO, G, HAMSHERE, M, MOSKVINA, V, JONES, N

Published in Neurology (03-04-2012)

“…Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated…”
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Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology by Zou, Fanggeng, Belbin, Olivia, Carrasquillo, Minerva M, Culley, Oliver J, Hunter, Talisha A, Ma, Li, Bisceglio, Gina D, Allen, Mariet, Dickson, Dennis W, Graff-Radford, Neill R, Petersen, Ronald C, Morgan, Kevin, Younkin, Steven G

Published in PloS one (28-05-2013)

“…GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds…”
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease by Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Hamshere, Marian L, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad R, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter A, Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schuermann, Britta, Heun, Reinhard, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frolich, Lutz, Hampel, Harald, et. al

Published in Nature genetics (01-06-2013)

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Education, occupation and retirement age effects on the age of onset of Alzheimer's disease by Lupton, Michelle K, Stahl, Daniel, Archer, Nicola, Foy, Catherine, Poppe, Michaela, Lovestone, Simon, Hollingworth, Paul, Williams, Julie, Owen, Micheal J, Dowzell, Kimberley, Abraham, Richard, Sims, Rebecca, Brayne, Carol, Rubinsztein, David, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Powell, John F

Published in International journal of geriatric psychiatry (01-01-2010)

“…Objective To determine the effects of early life education, mid life employment and later life retirement age on the age of onset (AOO) of Alzheimer's disease…”
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No evidence that extended tracts of homozygosity are associated with Alzheimer's disease by Sims, Rebecca, Dwyer, Sarah, Harold, Denise, Gerrish, Amy, Hollingworth, Paul, Chapman, Jade, Jones, Nicola, Abraham, Richard, Ivanov, Dobril, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Thomas, Charlene, Stretton, Alexandra, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K., Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S., Passmore, Peter A., Craig, David, McGuiness, Bernadette, Todd, Stephen, Johnston, Janet A., Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Jones, Lesley, Holmans, Peter A., O'Donovan, Michael, Owen, Michael J., Williams, Julie

Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01-12-2011)

“…We sought to investigate the contribution of extended runs of homozygosity in a genome‐wide association dataset of 1,955 Alzheimer's disease cases and 955…”
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Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease by Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Hamshere, Marian L, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad R, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter A, Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, Heun, Reinhard, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M, Kauwe, John S K, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter P, Van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E, Tsolaki, Magda, Singleton, Andrew B, Guerreiro, Rita, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V Shane, Younkin, Steven G, Holmans, Peter A, O'Donovan, Michael, Owen, Michael J, Williams, Julie

Published in Nature genetics (29-05-2013)

“…Nat. Genet. 41, 1088–1093 (2009); published online 6 September 2009; corrected after print 9 May 2013 In the version of this article initially published,…”
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Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease by Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Hamshere, Marian L, Pahwa, Jaspreet Singh, Moskvina, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad R, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle S, Passmore, Peter A, Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A David, Love, Seth, Kehoe, Patrick G, Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison M, Kauwe, John S K, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter P, Van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J, Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E, Tsolaki, Magda, Singleton, Andrew B, Guerreiro, Rita, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M, Pankratz, V Shane, Younkin, Steven G, Holmans, Peter A, O'Donovan, Michael, Owen, Michael J, Williams, Julie

Published in Nature genetics (01-10-2009)

“…Nat. Genet. 41, 1088–1093 (2009); published online 6 September; corrected after print 28 September 2009 In the version of this article initially published, the…”
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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes by Harold, Denise, Abraham, Richard, Hollingworth, Paul, Sims, Rebecca, Gerrish, Amy, Hamshere, Marian, Singh Pahwa, Jaspreet, Moskvina, Valentina, Dowzell, Kimberley, Williams, Amy, Jones, Nicola, Thomas, Charlene, Stretton, Alexandra, Morgan, Angharad, Lovestone, Simon, Powell, John, Proitsi, Petroula, Lupton, Michelle K, Brayne, Carol, Rubinsztein, David C., Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Morgan, Kevin, Brown, Kristelle, Passmore, Peter, Craig, David, McGuinness, Bernadette, Todd, Stephen, Holmes, Clive, Mann, David, Smith, A. David, Love, Seth, Kehoe, Patrick G., Hardy, John, Mead, Simon, Fox, Nick, Rossor, Martin, Collinge, John, Maier, Wolfgang, Jessen, Frank, Schürmann, Britta, van den Bussche, Hendrik, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Dichgans, Martin, Frölich, Lutz, Hampel, Harald, Hüll, Michael, Rujescu, Dan, Goate, Alison, Kauwe, John S.K., Cruchaga, Carlos, Nowotny, Petra, Morris, John C., Mayo, Kevin, Sleegers, Kristel, Bettens, Karolien, Engelborghs, Sebastiaan, De Deyn, Peter, van Broeckhoven, Christine, Livingston, Gill, Bass, Nicholas J., Gurling, Hugh, McQuillin, Andrew, Gwilliam, Rhian, Deloukas, Panagiotis, Al-Chalabi, Ammar, Shaw, Christopher E., Tsolaki, Magda, Singleton, Andrew, Guerreiro, Rita, Mühleisen, Thomas W., Nöthen, Markus M., Moebus, Susanne, Jöckel, Karl-Heinz, Klopp, Norman, Wichmann, H-Erich, Carrasquillo, Minerva M., Pankratz, V. Shane, Younkin, Steven G., Holmans, Peter, O'Donovan, Michael, Owen, Michael J., Williams, Julie

Published in Nature genetics (06-09-2009)

“…We undertook a two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals. In stage 1 (3,941 cases and 7,848 controls),…”
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