Search Results - "Downton, Matthew T."

Differences in protein structural regions that impact functional specificity in GT2 family β-glucan synthases by Oehme, Daniel P, Shafee, Thomas, Downton, Matthew T, Bacic, Antony, Doblin, Monika S

“…Most cell wall and secreted β-glucans are synthesised by the CAZy Glycosyltransferase 2 family (www.cazy.org), with different members catalysing the formation…”
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Characterization of the Lipid-Binding Site of Equinatoxin II by NMR and Molecular Dynamics Simulation by Weber, Daniel K., Yao, Shenggen, Rojko, Nejc, Anderluh, Gregor, Lybrand, Terry P., Downton, Matthew T., Wagner, John, Separovic, Frances

“…Equinatoxin II (EqtII) is a soluble, 20 kDa pore-forming protein toxin isolated from the sea anemone Actinia equina. Although pore formation has long been…”
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A dual role for the N-terminal domain of the IL-3 receptor in cell signalling by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.

“…The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and…”
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Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis by Hor, Lilian, Dobson, Renwick C.J., Downton, Matthew T., Wagner, John, Hutton, Craig A., Perugini, Matthew A.

“…Diaminopimelate (DAP) epimerase is involved in the biosynthesis of meso-DAP and lysine, which are important precursors for the synthesis of peptidoglycan,…”
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Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation by Gordon, Shane E, Weber, Daniel K, Downton, Matthew T, Wagner, John, Perugini, Matthew A

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the diaminopimelate pathway of bacteria, yielding amino acids required for cell wall…”
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Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine by Atkinson, Sarah C, Dogovski, Con, Downton, Matthew T, Pearce, F Grant, Reboul, Cyril F, Buckle, Ashley M, Gerrard, Juliet A, Dobson, Renwick C J, Wagner, John, Perugini, Matthew A

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the rate limiting step in lysine biosynthesis in bacteria and plants. The structure of DHDPS has been determined…”
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Unique Aspects of the Structure and Dynamics of Elementary IβCellulose Microfibrils Revealed by Computational Simulations by Oehme, Daniel P., Downton, Matthew T., Doblin, Monika S., Wagner, John, Gidley, Michael J., Bacic, Antony

“…The question of how many chains an elementary cellulose microfibril contains is critical to understanding the molecular mechanism(s) of cellulose biosynthesis…”
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Hydrogen bonds and twist in cellulose microfibrils by Kannam, Sridhar Kumar, Oehme, Daniel P., Doblin, Monika S., Gidley, Michael J., Bacic, Antony, Downton, Matthew T.

“…•The role of intra chain hydrogen bonds on the twist of cellulose was studied.•Multiple methods are used to explore the role of particular hydrogen bonds.•No…”
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Translational diffusion of proteins in nanochannels by Kannam, Sridhar Kumar, Downton, Matthew T

“…Hydrodynamic interactions play an important role in the transport of analytes through nanoscale devices. Of particular note is the role that no-slip boundary…”
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Gaining insight into cell wall cellulose macrofibril organisation by simulating microfibril adsorption by Oehme, Daniel P, Doblin, Monika S, Wagner, John, Bacic, Antony, Downton, Matthew T, Gidley, Michael J

“…One of the most important interactions within the paracrystalline matrix of the plant cell wall occurs between cellulose microfibrils to allow for the…”
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Membrane Insertion of a Dinuclear Polypyridylruthenium(II) Complex Revealed by Solid-State NMR and Molecular Dynamics Simulation: Implications for Selective Antibacterial Activity by Weber, Daniel K, Sani, Marc-Antoine, Downton, Matthew T, Separovic, Frances, Keene, F. Richard, Collins, J. Grant

“…Dinuclear polypyridylruthenium­(II) complexes bridged by a flexible methylene linker have received considerable interest as potential antibacterial agents…”
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Size-Dependent Fullerene–Fullerene Interactions in Water: A Molecular Dynamics Study by Makarucha, Adam J, Baldauf, Julia S, Downton, Matthew T, Yiapanis, George

“…Nested fullerenes display a range of unique properties influenced by their size and shape. In this paper, the size- and shape-dependent aggregation of nested…”
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Sensing of protein molecules through nanopores: a molecular dynamics study by Kannam, Sridhar Kumar, Kim, Sung Cheol, Rogers, Priscilla R, Gunn, Natalie, Wagner, John, Harrer, Stefan, Downton, Matthew T

“…Solid-state nanopores have been shown to be suitable for single molecule detection. While numerous modeling investigations exist for DNA within nanopores,…”
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Plasmodium falciparum glucose‐6‐phosphate dehydrogenase 6‐phosphogluconolactonase is a potential drug target by Allen, Stacey M, Lim, Erin E, Jortzik, Esther, Preuss, Janina, Chua, Hwa Huat, MacRae, James I, Rahlfs, Stefan, Haeussler, Kristina, Downton, Matthew T, McConville, Malcolm J, Becker, Katja, Ralph, Stuart A

“…The malarial parasite Plasmodium falciparum is exposed to substantial redox challenges during its complex life cycle. In intraerythrocytic parasites,…”
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Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition by Atkinson, Sarah C., Dogovski, Con, Downton, Matthew T., Czabotar, Peter E., Dobson, Renwick C. J., Gerrard, Juliet A., Wagner, John, Perugini, Matthew A.

“…Lysine is one of the most limiting amino acids in plants and its biosynthesis is carefully regulated through inhibition of the first committed step in the…”
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Quaternary Structure Analyses of an Essential Oligomeric Enzyme by Soares da Costa, Tatiana P, Christensen, Janni B, Desbois, Sebastien, Gordon, Shane E, Gupta, Ruchi, Hogan, Campbell J, Nelson, Tao G, Downton, Matthew T, Gardhi, Chamodi K, Abbott, Belinda M, Wagner, John, Panjikar, Santosh, Perugini, Matthew A

“…Here, we review recent studies aimed at defining the importance of quaternary structure to a model oligomeric enzyme, dihydrodipicolinate synthase. This will…”
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Single-polymer Brownian motor: a simulation study by Downton, Matthew T, Zuckermann, Martin J, Craig, Erin M, Plischke, Michael, Linke, Heiner

“…Numerical simulation is used to study a single polymer chain in a flashing ratchet potential to determine how the mechanism of this Brownian motor system is…”
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Geometric dependence of the conductance drop in a nanopore due to a particle by Kim, Sung Cheol, Kannam, Sridhar Kumar, Harrer, Stefan, Downton, Matthew T, Moore, Stephen, Wagner, John M

“…We study the effect of a neutral particle on the ionic flow through a nanopore using a basic uniform field theory and the coupled Poisson-Nernst-Planck and…”
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Differences in protein structural regions that impact functional specificity in GT2 family [beta]-glucan synthases by Oehme, Daniel P, Shafee, Thomas, Downton, Matthew T, Bacic, Antony, Doblin, Monika S

“…Most cell wall and secreted [beta]-glucans are synthesised by the CAZy Glycosyltransferase 2 family (www.cazy.org), with different members catalysing the…”
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Connecting microscopic simulations with kinetically constrained models of glasses by Downton, Matthew T, Kennett, Malcolm P

“…Kinetically constrained spin models are known to exhibit dynamical behavior mimicking that of glass forming systems. They are often understood as…”
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