Search Results - "Downs, Karen M."

The mouse allantois: new insights at the embryonic–extraembryonic interface by Downs, Karen M.

“…During the early development of Placentalia, a distinctive projection emerges at the posterior embryonic–extraembryonic interface of the conceptus; its…”
Get full text

The hypoblast (visceral endoderm): an evo-devo perspective by Stern, Claudio D, Downs, Karen M

“…When amniotes appeared during evolution, embryos freed themselves from intracellular nutrition; development slowed, the mid-blastula transition was lost and…”
Get full text

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors by Lalit, Pratik A., Salick, Max R., Nelson, Daryl O., Squirrell, Jayne M., Shafer, Christina M., Patel, Neel G., Saeed, Imaan, Schmuck, Eric G., Markandeya, Yogananda S., Wong, Rachel, Lea, Martin R., Eliceiri, Kevin W., Hacker, Timothy A., Crone, Wendy C., Kyba, Michael, Garry, Daniel J., Stewart, Ron, Thomson, James A., Downs, Karen M., Lyons, Gary E., Kamp, Timothy J.

“…Several studies have reported reprogramming of fibroblasts into induced cardiomyocytes; however, reprogramming into proliferative induced cardiac progenitor…”
Get full text

Severing umbilical ties by Wagenseil, Jessica E, Downs, Karen M

“…High levels of proteins called proteoglycans in the walls of umbilical arteries enable these arteries to close rapidly after birth and thus prevent blood loss…”
Get full text

The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential by Zeigler, Brandon M, Sugiyama, Daisuke, Chen, Michael, Guo, Yalin, Downs, Karen M, Speck, Nancy A

“…The chorio-allantoic placenta forms through the fusion of the allantois (progenitor tissue of the umbilical cord), with the chorionic plate. The murine…”
Get full text

Brachyury is required for elongation and vasculogenesis in the murine allantois by Inman, Kimberly E, Downs, Karen M

“…Mouse conceptuses homozygous for mutations in brachyury ( T ) exhibit a short, misshapen allantois that fails to fuse with the chorion. Ultimately, mutant…”
Get full text

Is extra-embryonic endoderm a source of placental blood cells? by Downs, Karen M.

“…•Hypoblast/visceral endoderm of Placentalia may be hematopoietic.•Putative blood cells have been observed in the hypoblast layer of the yolk sac.•Mouse…”
Get full text

Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse by Uy, Gary D, Downs, Karen M, Gardner, Richard L

“…At the blastocyst stage of pre-implantation mouse development, close contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of…”
Get full text

Developmentally Dynamic Histone Acetylation Pattern of a Tissue-Specific Chromatin Domain by Forsberg, E C, Downs, K M, Christensen, H M, Im, H, Nuzzi, P A, Bresnick, E H

“…We have defined the histone acetylation pattern of the endogenous murine β-globin domain, which contains the erythroid-specific β-globin genes. The β-globin…”
Get full text

Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation by Inman, Kimberly E., Downs, Karen M.

“…T-box gene family members have important roles during murine embryogenesis, gastrulation, and organogenesis. Although relatively little is known about how…”
Get full text

Extragonadal primordial germ cells or placental progenitor cells? by Downs, Karen M.

“…Primordial germ cells (PGCs), the precursors of the gametes, are now claimed to segregate within the extra-embryonic tissues of three species of placental…”
Get full text

Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation by Mukhopadhyay, Mahua, Teufel, Andreas, Yamashita, Tsuyoshi, Agulnick, Alan D, Chen, Lan, Downs, Karen M, Schindler, Alice, Grinberg, Alexander, Huang, Sing-Ping, Dorward, David, Westphal, Heiner

“…The LIM domain-binding protein 1 (Ldb1) is found in multi-protein complexes containing various combinations of LIM-homeodomain, LIM-only, bHLH, GATA and Otx…”
Get full text

Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula by Rodriguez, Adriana M., Downs, Karen M.

“…Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of the gut. Here, we provide evidence, currently limited to humans…”
Get full text

Systematic localization of oct‐3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development by Downs, Karen M.

“…Oct‐3/4 was localized to the mouse conceptus between the onset of gastrulation and 16‐somite pairs (‐s; ∼6.5–9.25 days postcoitum, dpc). Results revealed…”
Get full text

enigmatic primitive streak: prevailing notions and challenges concerning the body axis of mammals by Downs, Karen M

“…The primitive streak establishes the antero-posterior body axis in all amniote species. It is thought to be the conduit through which mesoderm and endoderm…”
Get full text

Upregulation of imprinted genes in mice: An insight into the intensity of gene expression and the evolution of genomic imprinting by Zaitoun, Ismail, Downs, Karen M., Rosa, Guilherme J. M., Khatib, Hasan

“…Imprinted genes are expressed monoallelically because one of the two copies is silenced epigentically in a parent-of-origin pattern. This pattern of expression…”
Get full text

PRDM1/BLIMP1 is widely distributed to the nascent fetal–placental interface in the mouse gastrula by Mikedis, Maria M., Downs, Karen M.

“…Background: PRDM1 is a transcriptional repressor that contributes to primordial germ cell (PGC) development. During early gastrulation, epiblast‐derived PRDM1…”
Get full text

STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula by Wolfe, Adam D., Rodriguez, Adriana M., Downs, Karen M.

“…The allantois-derived umbilical component of the chorio-allantoic placenta shuttles fetal blood to and from the chorion, thereby ensuring fetal-maternal…”
Get full text

Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos by Lalit, Pratik A, Rodriguez, Adriana M, Downs, Karen M, Kamp, Timothy J

“…Expandable and multipotent induced cardiac progenitor cells (iCPCs) are generated from mouse adult fibroblasts using forced expression of Mesp1, Tbx5, Gata4,…”
Get full text

Lineage commitments: emphasis on embryonic-extraembryonic interfaces by Downs, Karen M

“…The EMBO Workshop on 'Lineage Commitments: Emphasis on Embryonic-Extraembryonic Interfaces', held in May 2011, demonstrated that embryonic and extraembryonic…”
Get full text