Search Results - "Downs, Bradley"

Capturing ctDNA from Unaltered Stationary and Flowing Plasma with dCas9 by Downs, Bradley M., Sukumar, Saraswati

“…Many studies have established that blood-based liquid biopsies can be used to detect cancer in its early stages. However, the limiting factor for early cancer…”
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Detecting aberrant DNA methylation in Illumina DNA methylation arrays: a toolbox and recommendations for its use by Downs, Bradley M., Thursby, Sara-Jayne, Cope, Leslie

“…In this study, our goal was to determine probe-specific thresholds for identifying aberrant, or outlying, DNA methylation and to provide guidance on the…”
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Increasing the Capture Rate of Circulating Tumor DNA in Unaltered Plasma Using Passive Microfluidic Mixer Flow Cells by Downs, Bradley M., Hoang, Tra-My, Cope, Leslie

“…A limiting factor in using blood-based liquid biopsies for cancer detection is the volume of extracted blood required to capture a measurable number of…”
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The biological function of tumor-derived extracellular vesicles on metabolism by Fu, Xiaoyu, Song, Junlong, Yan, Wei, Downs, Bradley M, Wang, Weixing, Li, Juanjuan

“…Multiple studies have shown that extracellular vesicles (EVs) play a key role in the process of information transfer and material transport between cells. EVs…”
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HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells by Pai, Priya, Wang, Guannan, Teo, Wei Wen, Raez-Rodriguez, Diana, Gabrielson, Kathleen L, Győrffy, Balázs, Downs, Bradley M, Aggarwal, Akanksha, Sukumar, Saraswati

“…HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast epithelial cells and is frequently lost during malignant…”
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Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner by Mamo, Mahelet, Ye, I Chae, DiGiacomo, Josh W, Park, Je Yeon, Downs, Bradley, Gilkes, Daniele M

“…Intratumoral hypoxia occurs in 90% of solid tumors and is associated with a poor prognosis for patients. Cancer cells respond to hypoxic microenvironments by…”
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Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients by Kim, Yeong C, Zhao, Linli, Zhang, Hanwen, Huang, Ye, Cui, Jian, Xiao, Fengxia, Downs, Bradley, Wang, San Ming

“…Germline mutations in BRCA1 and BRCA2 are the most penetrating genetic predispositions for breast and ovarian cancer, and their presence is largely…”
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DNA Methylation Markers for Breast Cancer Detection in the Developing World by Downs, Bradley M, Mercado-Rodriguez, Claudia, Cimino-Mathews, Ashley, Chen, Chuang, Yuan, Jing-Ping, Van Den Berg, Eunice, Cope, Leslie M, Schmitt, Fernando, Tse, Gary M, Ali, Syed Z, Meir-Levi, Danielle, Sood, Rupali, Li, Juanjuan, Richardson, Andrea L, Mosunjac, Marina B, Rizzo, Monica, Tulac, Suzana, Kocmond, Kriszten J, de Guzman, Timothy, Lai, Edwin W, Rhees, Brian, Bates, Michael, Wolff, Antonio C, Gabrielson, Edward, Harvey, Susan C, Umbricht, Christopher B, Visvanathan, Kala, Fackler, Mary Jo, Sukumar, Saraswati

“…An unmet need in low-resource countries is an automated breast cancer detection assay to prioritize women who should undergo core breast biopsy and pathologic…”
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Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors by Downs, Bradley M, Ding, Wanjun, Cope, Leslie M, Umbricht, Christopher B, Li, Wenge, He, Huihua, Ke, Xiaokang, Holdhoff, Matthias, Bettegowda, Chetan, Tao, Weiping, Sukumar, Saraswati

“…Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we…”
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Automated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer by Li, Juanjuan, Downs, Bradley M., Cope, Leslie M., Fackler, Mary Jo, Zhang, Xiuyun, Song, Chuan-gui, VandenBussche, Christopher, Zhang, Kejing, Han, Yong, Liu, Yufei, Tulac, Suzana, Venkatesan, Neesha, de Guzman, Timothy, Chen, Chuang, Lai, Edwin W., Yuan, Jingping, Sukumar, Saraswati

“…Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB)…”
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Development of an automated liquid biopsy assay for methylated markers in advanced breast cancer by Fackler, Mary Jo, Tulac, Suzana, Venkatesan, Neesha, Aslam, Adam J, de Guzman, Timothy N, Mercado-Rodriguez, Claudia, Cope, Leslie M, Downs, Bradley M, Vali, Abdul Hussain, Ding, Wanjun, Lehman, Jennifer, Denbow, Rita, Reynolds, Jeffrey, Buckley, Morgan E, Visvanathan, Kala, Umbricht, Christopher B, Wolff, Antonio C, Stearns, Vered, Bates, Michael, Lai, Edwin W, Sukumar, Saraswati

“…Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a…”
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Targeted nanopore sequencing with Cas9-guided adapter ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukumar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Epigenetic changes in BRCA1 -mutated familial breast cancer by Downs, Bradley, Wang, San Ming

“…Familial breast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated…”
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Abstract 1388: A novel Hyper-Methylation Outlier method for blood biomarker discovery by Downs, Bradley M., Li, Juanjuan, Fackler, Mary Jo, Wolff, Antonio C., Sukumar, Saraswati, Umbricht, Chris B., Cope, Leslie M.

“…Abstract Introduction: DNA methylation analysis of circulating cell-free DNA in blood enables minimally invasive detection of screening early stage cancer, and…”
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Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers by Downs, Bradley, Sherman, Simon, Cui, Jian, Kim, Yeong C., Snyder, Carrie, Christensen, Maria, Luo, Jiangtao, Lynch, Henry, Wang, San Ming

“…The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of…”
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Targeted nanopore sequencing with Cas9-guided adaptor ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukmar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
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Abstract PS4-03: An automated DNA methylation assay for monitoring treatment response in patients with metastatic breast cancer by Fackler, Mary Jo, Tulac, Suzana, Venkatesan, Neesha, Aslam, Adam J., Cope, Leslie M., Lehman, Jennifer, Denbow, Rita, Reynolds, Jeffrey, Buckley, Morgan, Downs, Bradley M., Visvanathan, Kala, Umbricht, Christopher B., Wolff, Antonio C., Stearns, Vered, Lai, Edwin W., Sukumar, Saraswati

“…Abstract BACKGROUND: Previously, we demonstrated the clinical validity of cMethDNA, a circulating methylated tumor DNA (ctDNA) assay, in serum samples from…”
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Abstract P4-02-06: Automated molecular diagnosis of suspicious axillary lymph nodes in breast cancer patients by Li, Juanjuan, Downs, Bradley, Cope, Leslie, Zhang, Xiuyun, Song, Chuan-gui, Zhang, Kejing, Han, Yong, Fackler, Mary Jo, Lai, Edwin, Tulac, Suzana, Venkatesan, Neesha, Guzman, Timothy, Chen, Chuang, Yuan, Jingping, Sukumar, Saraswati

“…Abstract Background: Axillary lymph node metastasis is associated with a high risk of breast cancer recurrence and is the single most powerful predictor of…”
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Exome-based Variant Detection in Core Promoters by Kim, Yeong C., Cui, Jian, Luo, Jiangtao, Xiao, Fengxia, Downs, Bradley, Wang, San Ming

“…Core promoter controls the initiation of transcription. Core promoter sequence change can disrupt transcriptional regulation, lead to impairment of gene…”
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Abstract LB-220: An automated breast cancer detection assay for screening in the developing world by Downs, Bradley M., Fackler, Mary Jo, Mercado-Rodriguez, Claudia, Cimino-Mathews, Ashley, Chen, Chuang, Yuan, Jing-Ping, Berg, Eunice van den, Cope, Leslie M., Harvey, Susan C., Ali, Syed Z., Tulac, Suzana, Kocmond, Kriszten J., Lai, Edwin W., Rhees, Brian, Bates, Mike, Sukumar, Saraswati

“…Abstract Introduction: Breast cancer incidence is rapidly increasing globally with 1.7 million new cases and 600,000 deaths due to the disease annually. Death…”
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