Search Results - "Downing, James"

The biology of pediatric acute megakaryoblastic leukemia by Gruber, Tanja A., Downing, James R.

“…Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down…”
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Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis by Levine, Jacob H., Simonds, Erin F., Bendall, Sean C., Davis, Kara L., Amir, El-ad D., Tadmor, Michelle D., Litvin, Oren, Fienberg, Harris G., Jager, Astraea, Zunder, Eli R., Finck, Rachel, Gedman, Amanda L., Radtke, Ina, Downing, James R., Pe’er, Dana, Nolan, Garry P.

“…Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells, often within the same patient. Intratumor phenotypic and functional…”
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Genomics and the Continuum of Cancer Care by McDermott, Ultan, Downing, James R, Stratton, Michael R

“…Microarray analysis, involving assay of the expression of thousands of genes, and systematic DNA sequencing have led to tools and medicines now used in the…”
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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma by Chen, Xiang, Bahrami, Armita, Pappo, Alberto, Easton, John, Dalton, James, Hedlund, Erin, Ellison, David, Shurtleff, Sheila, Wu, Gang, Wei, Lei, Parker, Matthew, Rusch, Michael, Nagahawatte, Panduka, Wu, Jianrong, Mao, Shenghua, Boggs, Kristy, Mulder, Heather, Yergeau, Donald, Lu, Charles, Ding, Li, Edmonson, Michael, Qu, Chunxu, Wang, Jianmin, Li, Yongjin, Navid, Fariba, Daw, Najat C, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Zhang, Jinghui, Dyer, Michael A

“…Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To…”
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Exploring genomic alteration in pediatric cancer using ProteinPaint by Zhou, Xin, Edmonson, Michael N, Wilkinson, Mark R, Patel, Aman, Wu, Gang, Liu, Yu, Li, Yongjin, Zhang, Zhaojie, Rusch, Michael C, Parker, Matthew, Becksfort, Jared, Downing, James R, Zhang, Jinghui

“…The pediatric data set consists of 27,188 validated somatic coding lesions acquired at diagnosis or relapse from 17 subtypes of pediatric cancer, 252…”
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Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration by Pui, Ching-Hon, Yang, Jun J, Hunger, Stephen P, Pieters, Rob, Schrappe, Martin, Biondi, Andrea, Vora, Ajay, Baruchel, André, Silverman, Lewis B, Schmiegelow, Kjeld, Escherich, Gabriele, Horibe, Keizo, Benoit, Yves C M, Izraeli, Shai, Yeoh, Allen Eng Juh, Liang, Der-Cherng, Downing, James R, Evans, William E, Relling, Mary V, Mullighan, Charles G

“…To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. A…”
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Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16 by Jeha, Sima, Pei, Deqing, Choi, John, Cheng, Cheng, Sandlund, John T, Coustan-Smith, Elaine, Campana, Dario, Inaba, Hiroto, Rubnitz, Jeffrey E, Ribeiro, Raul C, Gruber, Tanja A, Raimondi, Susana C, Khan, Raja B, Yang, Jun J, Mullighan, Charles G, Downing, James R, Evans, William E, Relling, Mary V, Pui, Ching-Hon

“…Despite contemporary treatment, up to 10% of children with acute lymphoblastic leukemia still experience relapse. We evaluated whether a higher dosage of…”
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Joseph V. Simone: In Memoriam (1935-2021) by Downing, James R, Pui, Ching-Hon

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The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis by Aldiri, Issam, Xu, Beisi, Wang, Lu, Chen, Xiang, Hiler, Daniel, Griffiths, Lyra, Valentine, Marc, Shirinifard, Abbas, Thiagarajan, Suresh, Sablauer, Andras, Barabas, Marie-Elizabeth, Zhang, Jiakun, Johnson, Dianna, Frase, Sharon, Zhou, Xin, Easton, John, Zhang, Jinghui, Mardis, Elaine R., Wilson, Richard K., Downing, James R., Dyer, Michael A.

“…In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the…”
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The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia by Liu, Yu, Easton, John, Shao, Ying, Maciaszek, Jamie, Wang, Zhaoming, Wilkinson, Mark R, McCastlain, Kelly, Edmonson, Michael, Pounds, Stanley B, Shi, Lei, Zhou, Xin, Ma, Xiaotu, Sioson, Edgar, Li, Yongjin, Rusch, Michael, Gupta, Pankaj, Pei, Deqing, Cheng, Cheng, Smith, Malcolm A, Auvil, Jaime Guidry, Gerhard, Daniela S, Relling, Mary V, Winick, Naomi J, Carroll, Andrew J, Heerema, Nyla A, Raetz, Elizabeth, Devidas, Meenakshi, Willman, Cheryl L, Harvey, Richard C, Carroll, William L, Dunsmore, Kimberly P, Winter, Stuart S, Wood, Brent L, Sorrentino, Brian P, Downing, James R, Loh, Mignon L, Hunger, Stephen P, Zhang, Jinghui, Mullighan, Charles G

“…Charles Mullighan, Stephen Hunger, Jinghui Zhang and colleagues report a genomic analysis of 264 pediatric and young adult T-lineage acute lymphoblastic…”
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Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome by Rusch, Michael, Nakitandwe, Joy, Shurtleff, Sheila, Newman, Scott, Zhang, Zhaojie, Edmonson, Michael N., Parker, Matthew, Jiao, Yuannian, Ma, Xiaotu, Liu, Yanling, Gu, Jiali, Walsh, Michael F., Becksfort, Jared, Thrasher, Andrew, Li, Yongjin, McMurry, James, Hedlund, Erin, Patel, Aman, Easton, John, Yergeau, Donald, Vadodaria, Bhavin, Tatevossian, Ruth G., Raimondi, Susana, Hedges, Dale, Chen, Xiang, Hagiwara, Kohei, McGee, Rose, Robinson, Giles W., Klco, Jeffery M., Gruber, Tanja A., Ellison, David W., Downing, James R, Zhang, Jinghui

“…To evaluate the potential of an integrated clinical test to detect diverse classes of somatic and germline mutations relevant to pediatric oncology, we…”
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A novel retinoblastoma therapy from genomic and epigenetic analyses by Zhang, Jinghui, Benavente, Claudia A., McEvoy, Justina, Flores-Otero, Jacqueline, Ding, Li, Chen, Xiang, Ulyanov, Anatoly, Wu, Gang, Wilson, Matthew, Wang, Jianmin, Brennan, Rachel, Rusch, Michael, Manning, Amity L., Ma, Jing, Easton, John, Shurtleff, Sheila, Mullighan, Charles, Pounds, Stanley, Mukatira, Suraj, Gupta, Pankaj, Neale, Geoff, Zhao, David, Lu, Charles, Fulton, Robert S., Fulton, Lucinda L., Hong, Xin, Dooling, David J., Ochoa, Kerri, Naeve, Clayton, Dyson, Nicholas J., Mardis, Elaine R., Bahrami, Armita, Ellison, David, Wilson, Richard K., Downing, James R., Dyer, Michael A.

“…Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1 . Tumours progress very quickly…”
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Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations by Brady, Samuel W., Liu, Yanling, Ma, Xiaotu, Gout, Alexander M., Hagiwara, Kohei, Zhou, Xin, Wang, Jian, Macias, Michael, Chen, Xiaolong, Easton, John, Mulder, Heather L., Rusch, Michael, Wang, Lu, Nakitandwe, Joy, Lei, Shaohua, Davis, Eric M., Naranjo, Arlene, Cheng, Cheng, Maris, John M., Downing, James R., Cheung, Nai-Kong V., Hogarty, Michael D., Dyer, Michael A., Zhang, Jinghui

“…Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better understand neuroblastoma pathogenesis, here we analyze whole-genome,…”
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Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma by Chen, Xiang, Stewart, Elizabeth, Shelat, Anang A., Qu, Chunxu, Bahrami, Armita, Hatley, Mark, Wu, Gang, Bradley, Cori, McEvoy, Justina, Pappo, Alberto, Spunt, Sheri, Valentine, Marcus B., Valentine, Virginia, Krafcik, Fred, Lang, Walter H., Wierdl, Monika, Tsurkan, Lyudmila, Tolleman, Viktor, Federico, Sara M., Morton, Chris, Lu, Charles, Ding, Li, Easton, John, Rusch, Michael, Nagahawatte, Panduka, Wang, Jianmin, Parker, Matthew, Wei, Lei, Hedlund, Erin, Finkelstein, David, Edmonson, Michael, Shurtleff, Sheila, Boggs, Kristy, Mulder, Heather, Yergeau, Donald, Skapek, Steve, Hawkins, Douglas S., Ramirez, Nilsa, Potter, Philip M., Sandoval, John A., Davidoff, Andrew M., Mardis, Elaine R., Wilson, Richard K., Zhang, Jinghui, Downing, James R., Dyer, Michael A.

“…Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic…”
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Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia by Mullighan, Charles G., Phillips, Letha A., Su, Xiaoping, Ma, Jing, Miller, Christopher B., Shurtleff, Sheila A., Downing, James R.

“…Most children with acute lymphoblastic leukemia (ALL) can be cured, but the prognosis is dismal for the minority of patients who relapse after treatment. To…”
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CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data by Tian, Liqing, Li, Yongjin, Edmonson, Michael N, Zhou, Xin, Newman, Scott, McLeod, Clay, Thrasher, Andrew, Liu, Yu, Tang, Bo, Rusch, Michael C, Easton, John, Ma, Jing, Davis, Eric, Trull, Austyn, Michael, J Robert, Szlachta, Karol, Mullighan, Charles, Baker, Suzanne J, Downing, James R, Ellison, David W, Zhang, Jinghui

“…To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based algorithm that integrates RNA-seq read…”
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Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia by Coustan-Smith, Elaine, MS, Mullighan, Charles G, MD, Onciu, Mihaela, MD, Behm, Frederick G, Prof, Raimondi, Susana C, Prof, Pei, Deqing, MS, Cheng, Cheng, PhD, Su, Xiaoping, PhD, Rubnitz, Jeffrey E, MD, Basso, Giuseppe, Prof, Biondi, Andrea, Prof, Pui, Ching-Hon, Prof, Downing, James R, Prof, Campana, Dario, Prof

“…Summary Background About a fifth of children with acute T-lymphoblastic leukaemia (T-ALL) succumb to the disease, suggesting an unrecognised biological…”
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Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study by Pui, Ching-Hon, Prof, Pei, Deqing, MS, Coustan-Smith, Elaine, MS, Jeha, Sima, Prof, Cheng, Cheng, Prof, Bowman, W Paul, MD, Sandlund, John T, Prof, Ribeiro, Raul C, Prof, Rubnitz, Jeffrey E, Prof, Inaba, Hiroto, MD PhD, Bhojwani, Deepa, MD, Gruber, Tanja A, MD PhD, Leung, Wing H, Prof, Downing, James R, Prof, Evans, William E, Prof, Relling, Mary V, Prof, Campana, Dario, Prof

“…Summary Background The level of minimal residual disease during remission induction is the most important prognostic indicator in patients with acute…”
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Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia by Topka, Sabine, Vijai, Joseph, Walsh, Michael F, Jacobs, Lauren, Maria, Ann, Villano, Danylo, Gaddam, Pragna, Wu, Gang, McGee, Rose B, Quinn, Emily, Inaba, Hiroto, Hartford, Christine, Pui, Ching-Hon, Pappo, Alberto, Edmonson, Michael, Zhang, Michael Y, Stepensky, Polina, Steinherz, Peter, Schrader, Kasmintan, Lincoln, Anne, Bussel, James, Lipkin, Steve M, Goldgur, Yehuda, Harit, Mira, Stadler, Zsofia K, Mullighan, Charles, Weintraub, Michael, Shimamura, Akiko, Zhang, Jinghui, Downing, James R, Nichols, Kim E, Offit, Kenneth

“…Somatic mutations affecting ETV6 often occur in acute lymphoblastic leukemia (ALL), the most common childhood malignancy. The genetic factors that predispose…”
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New markers for minimal residual disease detection in acute lymphoblastic leukemia by Coustan-Smith, Elaine, Song, Guangchun, Clark, Christopher, Key, Laura, Liu, Peixin, Mehrpooya, Mohammad, Stow, Patricia, Su, Xiaoping, Shurtleff, Sheila, Pui, Ching-Hon, Downing, James R., Campana, Dario

“…To identify new markers for minimal residual disease (MRD) detection in acute lymphoblastic leukemia (ALL), we compared genome-wide gene expression of…”
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