Search Results - "Downie, David L"
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Novel 384-well population patch clamp electrophysiology assays for Ca2+-activated K+ channels
Published in Journal of biomolecular screening (01-02-2007)“…Planar array electrophysiology techniques were applied to assays for modulators of recombinant hIK and hSK3 Ca2+-activated K+ channels. In CHO-hIK-expressing…”
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Effects of thiopental and its optical isomers on nicotinic acetylcholine receptors
Published in Anesthesiology (Philadelphia) (01-09-2000)“…With the exception of gamma-aminobutyric acidA (GABAA) receptors, the major molecular targets underlying the anesthetizing actions of thiopental have yet to be…”
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Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases
Published in Bioorganic & medicinal chemistry letters (15-12-2011)“…As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram…”
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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases
Published in Bioorganic & medicinal chemistry letters (15-12-2011)“…We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this…”
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Use of planar array electrophysiology for the development of robust ion channel cell lines
Published in Combinatorial chemistry & high throughput screening (01-01-2009)“…The tractability of ion channels as drug targets has been significantly improved by the advent of planar array electrophysiology platforms which have…”
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Detached, Purified Nerve Terminals from Skate Electric Organ for Biochemical and Physiological Studies
Published in The Biological bulletin (Lancaster) (01-02-1996)“…Electric organs of skate (Raja species) dissociate to form populations of individual electrocytes when incubated in saline solutions containing collagenase…”
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The interaction of trichloroethanol with murine recombinant 5‐HT3 receptors
Published in British journal of pharmacology (01-04-1995)“…1 The effects of ethanol, chloral hydrate and trichloroethanol upon the 5‐HT3 receptor have been investigated by use of electrophysiological techniques applied…”
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The interaction of trichloroethanol with murine recombinant 5‐HT 3 receptors
Published in British journal of pharmacology (01-04-1995)“…The effects of ethanol, chloral hydrate and trichloroethanol upon the 5‐HT 3 receptor have been investigated by use of electrophysiological techniques applied…”
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Northern Lights Against POPS. Combating Toxic Threats in the Arctic
Published in Canadian Ethnic Studies (22-06-2004)“…Section two, "Regional and Global POPs Policy," does much to explain numerous international efforts to minimize POPs. For instance, the first chapter discusses…”
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Global environmental politics
Published in Natural resources forum (01-08-2006)Get full text
Book Review -
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Global environmental politics
Published in Natural resources journal (01-01-2006)Get full text
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Handbuch Globale Umweltpolitik. Mit einem Vorwort von Sigmar Gabriel
Published in Zeitschrift für Politik (01-09-2007)Get full text
Book Review