Search Results - "Downes, J. J."

Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS) by Downes, Martin J, Brennan, Marnie L, Williams, Hywel C, Dean, Rachel S

“…ObjectivesThe aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in…”
Get full text

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus by Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O. J., Hughes, Jim R.

“…The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association…”
Get full text

Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo by Hanssen, Lars L. P., Kassouf, Mira T., Oudelaar, A. Marieke, Biggs, Daniel, Preece, Chris, Downes, Damien J., Gosden, Matthew, Sharpe, Jacqueline A., Sloane-Stanley, Jacqueline A., Hughes, Jim R., Davies, Benjamin, Higgs, Douglas R.

“…The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into 1–5 megabase (Mb) topologically associated domains (TADs), and further…”
Get full text

Magneto-mechanical trapping of micro-diamonds at low pressures by O'Brien, M. C., Dunn, S., Downes, J. E., Twamley, J.

“…A number of quantum technologies require macroscopic mechanical oscillators possessing ultra-high motional Q-factors. These can be used to explore the…”
Get full text

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation by Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.

“…Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are…”
Get full text

Controlling the motional quality factor of a diamagnetically levitated graphite plate by Romagnoli, P., Lecamwasam, R., Tian, S., Downes, J. E., Twamley, J.

“…Researchers seek methods to levitate matter for a wide variety of purposes, ranging from exploring fundamental problems in science through to developing new…”
Get full text

Telephone consultations for general practice: a systematic review by Downes, Martin J, Mervin, Merehau C, Byrnes, Joshua M, Scuffham, Paul A

“…The use of information technology, including internet- and telephone-based resources, is becoming an alternative and supporting method of providing many forms…”
Get full text

Vancomycin‐Induced Kidney Injury: Animal Models of Toxicodynamics, Mechanisms of Injury, Human Translation, and Potential Strategies for Prevention by Pais, Gwendolyn M., Liu, Jiajun, Zepcan, Sanja, Avedissian, Sean N., Rhodes, Nathaniel J., Downes, Kevin J., Moorthy, Ganesh S., Scheetz, Marc H.

“…Vancomycin is a recommended therapy in multiple national guidelines. Despite the common use, there is a poor understanding of the mechanistic drivers and…”
Get full text

Vip3A resistance alleles exist at high levels in Australian targets before release of cotton expressing this toxin by Mahon, Rod J, Downes, Sharon J, James, Bill

“…Crops engineered to produce insecticidal crystal (Cry) proteins from the soil bacterium Bacillus thuringiensis (Bt) have revolutionised pest control in…”
Get full text

Enhanced etch rate of deep-UV laser induced etching of diamond in low pressure conditions by Baldwin, C. G., Downes, J. E., Mildren, R. P.

“…Ultraviolet laser-induced etching is a method of machining and nanostructuring diamond surfaces in which carbon is removed from the surface via a photochemical…”
Get full text

Flow regulation reduces native plant cover and facilitates exotic invasion in riparian wetlands by Catford, Jane A., Downes, Barbara J., Gippel, Christopher J., Vesk, Peter A.

“…1. River regulation and exotic plant invasion threaten riverine ecosystems, and the two often co-occur. By altering water regimes, flow regulation can…”
Get full text

Feedback cooling of an insulating high-Q diamagnetically levitated plate by Tian, S., Jadeja, K., Kim, D., Hodges, A., Hermosa, G. C., Cusicanqui, C., Lecamwasam, R., Downes, J. E., Twamley, J.

“…Levitated systems in vacuum have many potential applications ranging from new types of inertial and magnetic sensors through to fundamental issues in quantum…”
Get full text

American College of Rheumatology Guidance for the Management of Pediatric Rheumatic Disease During the COVID‐19 Pandemic: Version 2 by Wahezi, Dawn M., Lo, Mindy S., Rubinstein, Tamar B., Ringold, Sarah, Ardoin, Stacy P., Downes, Kevin J., Jones, Karla B., Laxer, Ronald M., Pellet Madan, Rebecca, Mudano, Amy S., Turner, Amy S., Karp, David R., Mehta, Jay J.

“…Objective To provide clinical guidance to rheumatology providers who treat children with pediatric rheumatic disease (PRD) in the context of the coronavirus…”
Get full text

Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model by Pais, Gwendolyn M, Liu, Jiajun, Avedissian, Sean N, Hiner, Danielle, Xanthos, Theodoros, Chalkias, Athanasios, d’Aloja, Ernesto, Locci, Emanuela, Gilchrist, Annette, Prozialeck, Walter C, Rhodes, Nathaniel J, Lodise, Thomas P, Fitzgerald, Julie C, Downes, Kevin J, Zuppa, Athena F, Scheetz, Marc H

“…Abstract Background Vancomycin and piperacillin/tazobactam are reported in clinical studies to increase acute kidney injury (AKI). However, no clinical study…”
Get full text

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin by Truch, Julia, Downes, Damien J., Scott, Caroline, Gür, E. Ravza, Telenius, Jelena M., Repapi, Emmanouela, Schwessinger, Ron, Gosden, Matthew, Brown, Jill M., Taylor, Stephen, Cheong, Pak Leng, Hughes, Jim R., Higgs, Douglas R., Gibbons, Richard J.

“…The chromatin remodeller ATRX interacts with the histone chaperone DAXX to deposit the histone variant H3.3 at sites of nucleosome turnover. ATRX is known to…”
Get full text

Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction by Downes, Thomas J, Cheruvu, Manikandar S, Karunaratne, Tennekoon B, De Giorgio, Roberto, Farmer, Adam D

“…Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder characterized by an impairment of coordinated propulsive activity in the gastrointestinal (GI)…”
Get full text

YETI observations of the young transiting planet candidate CVSO 30 b by Raetz, St, Schmidt, T. O. B., Czesla, S., Klocová, T., Holmes, L., Errmann, R., Kitze, M., Fernández, M., Sota, A., Briceño, C., Hernández, J., Downes, J. J., Dimitrov, D. P., Kjurkchieva, D., Radeva, V., Wu, Z.-Y., Zhou, X., Takahashi, H., Henych, T., Seeliger, M., Mugrauer, M., Adam, Ch, Marka, C., Schmidt, J. G., Hohle, M. M., Ginski, Ch, Pribulla, T., Trepl, L., Moualla, M., Pawellek, N., Gelszinnis, J., Buder, S., Masda, S., Maciejewski, G., Neuhäuser, R.

“…CVSO 30 is a unique young low-mass system, because, for the first time, a close-in transiting and a wide directly imaged planet candidates are found around a…”
Get full text

Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury by Pais, Gwendolyn M, Avedissian, Sean N, O'Donnell, J Nicholas, Rhodes, Nathaniel J, Lodise, Thomas P, Prozialeck, Walter C, Lamar, Peter C, Cluff, Cameron, Gulati, Anil, Fitzgerald, Julie C, Downes, Kevin J, Zuppa, Athena F, Scheetz, Marc H

“…Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of…”
Get full text

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker by Bozhilov, Yavor K., Downes, Damien J., Telenius, Jelena, Marieke Oudelaar, A., Olivier, Emmanuel N., Mountford, Joanne C., Hughes, Jim R., Gibbons, Richard J., Higgs, Douglas R.

“…Many single nucleotide variants (SNVs) associated with human traits and genetic diseases are thought to alter the activity of existing regulatory elements…”
Get full text

Comparing the two leading erythroid lines BEL-A and HUDEP-2 by Daniels, Deborah E, Downes, Damien J, Ferrer-Vicens, Ivan, Ferguson, Daniel C J, Singleton, Belinda K, Wilson, Marieangela C, Trakarnsanga, Kongtana, Kurita, Ryo, Nakamura, Yukio, Anstee, David J, Frayne, Jan

Get full text