Search Results - "Downard, Kevin M."

Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review by Griffin, Justin H., Downard, Kevin M.

“…This article reviews the many and varied mass spectrometry based responses to the SARS-CoV2 coronavirus amidst a continuing global healthcare crisis. Although…”
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Amino Acid Composition Determination From the Fractional Mass of Peptides by Downard, Kevin M., Cody, Robert B.

“…ABSTRACT A peptide's fractional mass is directly associated with its elemental composition and thus amino acid composition. Here it is demonstrated that a…”
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Concentration of hydroxyl radicals during electrical discharge for radical probe protein footprinting mass spectrometry by Downard, Kevin. M.

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Darwin’s Tree of Life is Numbered. Resolving the Origins of Species by Mass by Downard, Kevin M.

“…A new view of the tree of life has been conceived and implemented to construct a molecular-based phylogeny for a wide range of animal species without the need…”
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Indirect study of non-covalent protein complexes by MALDI mass spectrometry: Origins, advantages, and applications of the "intensity-fading" approach by Downard, Kevin M.

“…This review article describes the origins, advantages, and application of an indirect approach with which to study protein and other macromolecular complexes…”
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Proteotyping for the rapid identification of influenza virus and other biopathogens by Downard, Kevin M

“…The influenza virus is one of the most deadly infectious agents known to man and has been responsible for the deaths of some hundred million lives throughout…”
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Advances in radical probe mass spectrometry for protein footprinting in chemical biology applications by Maleknia, Simin D, Downard, Kevin M

“…Radical Probe Mass Spectrometry (RP-MS), first introduced in 1999, utilizes hydroxyl radicals generated directly within aqueous solutions using synchrotron…”
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Mutational analysis employing a phylogenetic mass tree approach in a study of the evolution of the influenza virus by Akand, Elma H., Downard, Kevin. M.

“…[Display omitted] •Development of mass tree approach to identify and display protein mutations.•Phylogenetics methodology which avoids the need for gene or…”
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Mechanisms of antiviral resistance in influenza neuraminidase revealed by a mass spectrometry based phylonumerics approach by Akand, Elma H., Downard, Kevin M.

“…[Display omitted] •Mass based phylonumerics approach to study antiviral resistance in neuraminidase.•Most frequent ancestral and descendant mutations are…”
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25 Years Responding to Respiratory and Other Viruses with Mass Spectrometry by Downard, Kevin M.

“…This review article presents the development and application of mass spectrometry (MS) approaches, developed in the author’s laboratory over the past 25 years,…”
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Resolving omicron sub-variants of SARS CoV-2 coronavirus with MALDI mass spectrometry by Lanyon, Henry E, Hoyle, Joshua S, Downard, Kevin M

“…Mass mapping using high resolution mass spectrometry has been applied to identify and rapidly distinguish the omicron sub-variants across the BA.1-BA.5…”
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Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach by Akand, Elma H., Downard, Kevin.M.

“…[Display omitted] •Application of mass-based protein phylogenetic approach to study influenza evolution.•Epistatic mutations within H3 hemaglutinin in type A…”
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Rapid identification of SARS CoV-2 omicron sub-variant JN.1 (BA.2.86.1.1) with mass spectrometry by Lanyon, Henry E., Downard, Kevin M.

“…•Rapid Identification of new SARS CoV-2 omicron sub-variant JN.1 virus.•Mass spectrometry detects L455S mutation peptide biomarker in clinical…”
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Evolution of Influenza Neuraminidase and the Detection of Antiviral Resistant Strains Using Mass Trees by Swaminathan, Kavya, Downard, Kevin M

“…A new approach employing mass trees is described and implemented which enables the evolution of influenza neuraminidase across all subtypes (N1–N9) in human…”
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Effect of charge on the conformation of highly basic peptides including the tail regions of histone proteins by ion mobility mass spectrometry by Akashi, Satoko, Downard, Kevin M.

“…The first systematic and comprehensive study of the charging behaviour and effect of charge on the conformation of specifically constructed arginine-rich…”
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Reimaging the Tree of Life Using a Mass Based Phylonumerics Approach by Akand, Elma H., Downard, Kevin M.

“…Evolutionary relationships among and across species are almost exclusively examined through phylogenetic analysis based on trees constructed using gene…”
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Incorporation of a Proteotyping Approach Using Mass Spectrometry for Surveillance of Influenza Virus in Cell-Cultured Strains by Fernandes, Neil D, Downard, Kevin M

“…Classifications Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Evolution of Type B Influenza Virus Using a Mass Spectrometry Based Phylonumerics Approach by Akand, Elma H., Downard, Kevin M.

“…A mass spectrometry based phylonumerics approach has been applied to study the molecular evolution of influenza hemagglutinin of type B strains of the Victoria…”
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Subtyping of influenza neuraminidase using mass spectrometry by Nguyen, An P, Downard, Kevin M

“…A proteotyping approach which employs high resolution mass spectrometry is shown to be able to differentiate all nine neuraminidase subtypes of type A…”
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Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry by Swaminathan, Kavya, Dyason, Jeffrey C., Maggioni, Andrea, von Itzstein, Mark, Downard, Kevin M.

“…The binding of a natural anthocyanin to influenza neuraminidase has been studied employing mass spectrometry and molecular docking. Derived from a black…”
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