Search Results - "Dowling, Quinton M."

Computational design of constitutively active cGAS by Dowling, Quinton M., Volkman, Hannah E., Gray, Elizabeth E., Ovchinnikov, Sergey, Cambier, Stephanie, Bera, Asim K., Sankaran, Banumathi, Johnson, Max R., Bick, Matthew J., Kang, Alex, Stetson, Daniel B., King, Neil P.

“…Cyclic GMP–AMP synthase (cGAS) is a pattern recognition receptor critical for the innate immune response to intracellular pathogens, DNA damage, tumorigenesis…”
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Particle Sizing of Nanoparticle Adjuvant Formulations by Dynamic Light Scattering (DLS) and Nanoparticle Tracking Analysis (NTA) by Chan, Michelle Y, Dowling, Quinton M, Sivananthan, Sandra J, Kramer, Ryan M

“…Dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) are two orthogonal and complementary methods of measuring size of particles in a…”
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Quantification of Multiple Components of Complex Aluminum-Based Adjuvant Mixtures by Using Fourier Transform Infrared Spectroscopy and Partial Least Squares Modeling by Dowling, Quinton M, Kramer, Ryan M

“…Fourier transform infrared (FTIR) spectroscopy is widely used in the pharmaceutical industry for process monitoring, compositional quantification, and…”
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In vitro evaluation of TLR4 agonist activity: Formulation effects by Misquith, Ayesha, Fung, H.W. Millie, Dowling, Quinton M., Guderian, Jeffrey A., Vedvick, Thomas S., Fox, Christopher B.

“…•TLR4 ligands are promising vaccine adjuvant candidates.•In vitro assays (e.g. macrophage cytokine production) evaluate adjuvant activity.•Different…”
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Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach by Kramer, Ryan M, Archer, Michelle C, Orr, Mark T, Dubois Cauwelaert, Natasha, Beebe, Elyse A, Huang, Po-Wei D, Dowling, Quinton M, Schwartz, Alicia M, Fedor, Dawn M, Vedvick, Thomas S, Fox, Christopher B

“…Adjuvants have the potential to increase the efficacy of protein-based vaccines but need to be maintained within specific temperature and storage conditions…”
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Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization by Orr, Mark T., Kramer, Ryan M., Barnes, Lucien, Dowling, Quinton M., Desbien, Anthony L., Beebe, Elyse A., Laurance, John D., Fox, Christopher B., Reed, Steven G., Coler, Rhea N., Vedvick, Thomas S.

“…Next-generation rationally-designed vaccine adjuvants represent a significant breakthrough to enable development of vaccines against challenging diseases…”
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Working together: interactions between vaccine antigens and adjuvants by Fox, Christopher B., Kramer, Ryan M., Barnes V, Lucien, Dowling, Quinton M., Vedvick, Thomas S.

“…The development of vaccines containing adjuvants has the potential to enhance antibody and cellular immune responses, broaden protective immunity against…”
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Quantitative measurement of Toll-like receptor 4 agonists adsorbed to Alhydrogel(®) by Fourier transform infrared-attenuated total reflectance spectroscopy by Dowling, Quinton M, Schwartz, Alicia M, Vedvick, Thomas S, Fox, Christopher B, Kramer, Ryan M

“…Aluminum salts have a long history as safe and effective vaccine adjuvants. In addition, aluminum salts have high adsorptive capacities for vaccine antigens…”
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Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes by Fox, Christopher B, Mulligan, Sean K, Sung, Joyce, Dowling, Quinton M, Fung, H W Millie, Vedvick, Thomas S, Coler, Rhea N

“…Development of lipid-based adjuvant formulations to enhance the immunogenicity of recombinant vaccine antigens is a focus of modern vaccine research…”
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Lyophilization of an Adjuvanted Mycobacterium tuberculosis Vaccine in a Single-Chamber Pharmaceutical Cartridge by Barnes V, Lucien, Fedor, Dawn M., Williams, Simon, Dowling, Quinton M., Archer, Michelle C., Cloutier, Sylvain, Parker, Sarah, Vedvick, Thomas S., Fox, Christopher B., Kramer, Ryan M.

“…Although substantial effort has been made in the development of next-generation recombinant vaccine systems, maintenance of a cold chain is still typically…”
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Modulating potency: Physicochemical characteristics are a determining factor of TLR4-agonist nanosuspension activity by Dowling, Quinton M, Sivananthan, Sandra J, Guderian, Jeff A, Moutaftsi, Magdalini, Chesko, James D, Fox, Christopher B, Vedvick, Thomas S, Kramer, Ryan M

“…Activity of adjuvanted vaccines is difficult to predict in vitro and in vivo. The wide compositional and conformational range of formulated adjuvants, from…”
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Methods and Applications of Computational Design in Multiple States by Dowling, Quinton M

“…The balance between flexibility and stability is a key property of proteins, contributing to the vast area of structures and functions observed in nature…”
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