Search Results - "Dowle, Mike D."

Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR by Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.

“…Several series of pyrazolo[3,4-b]pyridine-5-heterocycles have been identified as potent inhibitors of PDE4B. Molecular modelling and X-ray crystallography on…”
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Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease by Andrews, David M, Barnes, Michael C, Dowle, Mike D, Hind, S. Lucy, Johnson, Martin R, Jones, Paul S, Mills, Gail, Patikis, Angela, Pateman, Tony J, Redfern, Tracy J, Robinson, J. Ed, Slater, Martin J, Trivedi, Naimisha

“…In this, the second of two Letters, the optimization of the pyrrolidine-5,5-trans-lactam template (exemplified by 1a) as a mechanism-based inhibitor of…”
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The design of potent, non-peptidic inhibitors of hepatitis C protease by Andrews, David M., Chaignot, Helene M., Coomber, Barry A., Dowle, Mike D., Lucy Hind, S., Johnson, Martin R., Jones, Paul S., Mills, Gail, Patikis, Angela, Pateman, Tony J., Ed Robinson, J., Slater, Martin J., Trivedi, Naimisha

“…The pyrrolidine-5,5- trans-lactam template was used to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease displaying potent…”
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