Search Results - "Dower, Nancy A."

RasGRPs are targets of the anti-cancer agent ingenol-3-angelate by Song, Xiaohua, Lopez-Campistrous, Ana, Sun, Lucy, Dower, Nancy A, Kedei, Noemi, Yang, Jing, Kelsey, Jessica S, Lewin, Nancy E, Esch, Tim E, Blumberg, Peter M, Stone, James C

“…Ingenol-3-angelate (I3A) is a non-tumor promoting phorbol ester-like compound identified in the sap of Euphoria peplus. Similar to tumor promoting phorbol…”
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RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling by Coughlin, Jason J, Stang, Stacey L, Dower, Nancy A, Stone, James C

“…The RasGRPs are a family of Ras activators that possess diacylglycerol-binding C1 domains. In T cells, RasGRP1 links TCR signaling to Ras. B cells coexpress…”
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RasGRP is essential for mouse thymocyte differentiation and TCR signaling by Stone, James C, Dower, Nancy A, Stang, Stacey L, Bottorff, Drell A, Ebinu, Julius O, Dickie, Peter, Ostergaard, Hanne L

“…The Ras signaling pathway plays a critical role in thymopoiesis and T cell activation, but the mechanism of Ras regulation is controversial. At least one mode…”
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RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4 by Golec, Dominic P, Dower, Nancy A, Stone, James C, Baldwin, Troy A

“…T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the…”
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A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells by Stang, Stacey L, Lopez-Campistrous, Ana, Song, Xiaohua, Dower, Nancy A, Blumberg, Peter M, Wender, Paul A, Stone, James C

“…Objective Bryostatin-1 and related diacylglycerol (DAG) analogues activate RasGRPs in lymphocytes, thereby activating Ras and mimicking some aspects of immune…”
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Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1 by Layer, Katrin, Lin, Guosheng, Nencion, Alessio, Hu, Wei, Schmucker, Adam, Antov, Andrey N., Li, Xiaoyu, Takamatsu, Satoshi, Chevassut, Timothy, Dower, Nancy A., Stang, Stacey L., Beier, David, Buhlmann, Janet, Bronson, Roderick T., Elkon, Keith B., Stone, James C., Van Parijs, Luk, Lim, Bing

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Familial Recurrence of Cerebral Palsy with Multiple Risk Factors by Richer, Lawrence P., Dower, Nancy A., Leonard, Norma, Chan, Alicia K. J., Robertson, Charlene M. T.

“…The recurrence of cerebral palsy in the same family is uncommon. We, however, report on two families with two or more affected siblings. In both families,…”
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RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation by Priatel, John J, Teh, Soo-Jeet, Dower, Nancy A, Stone, James C, Teh, Hung-Sia

“…Two important Ras-guanyl nucleotide exchange factors, Sos and RasGRP1, control Ras activation in thymocytes. However, the relative contribution of these two…”
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RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes by Sharma, Amrish, Luke, Courtney T., Dower, Nancy A., Stone, James C., Lorenzo, Patricia S.

“…RasGRP1 is a guanine nucleotide exchange factor for Ras that binds with high affinity to diacylglycerol analogs like the phorbol esters. Recently, we…”
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Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines by Lopez-Campistrous, Ana, Song, Xiaohua, Schrier, Adam J, Wender, Paul A, Dower, Nancy A, Stone, James C

“…The anti-cancer effects of bryostatin-1, a potent diacylglycerol analogue, have traditionally been attributed to its action on protein kinase C. However, we…”
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RETRACTED: Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1 by Layer, Katrin, Lin, Guosheng, Nencioni, Alessio, Hu, Wei, Schmucker, Adam, Antov, Andrey N., Li, Xiaoyu, Takamatsu, Satoshi, Chevassut, Timothy, Dower, Nancy A., Stang, Stacey L., Beier, David, Buhlmann, Janet, Bronson, Roderick T., Elkon, Keith B., Stone, James C., Van Parijs, Luk, Lim, Bing

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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RasGRP1 Transgenic Mice Develop Cutaneous Squamous Cell Carcinomas in Response to Skin Wounding: Potential Role of Granulocyte Colony-Stimulating Factor by Diez, Federico R, Garrido, Ann A, Sharma, Amrish, Luke, Courtney T, Stone, James C, Dower, Nancy A, Cline, J. Mark, Lorenzo, Patricia S

“…Models of epidermal carcinogenesis have demonstrated that Ras is a critical molecule involved in tumor initiation and progression. Previously, we have shown…”
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Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1 by Layer, Katrin, Lin, Guosheng, Nencioni, Alessio, Hu, Wei, Schmucker, Adam, Antov, Andrey N, Li, Xiaoyu, Takamatsu, Satoshi, Chevassut, Timothy, Dower, Nancy A, Stang, Stacey L, Beier, David, Buhlmann, Janet, Bronson, Roderick T, Elkon, Keith B, Stone, James C, Van Parijs, Luk, Lim, Bing

“…A mouse strain was identified with a recessive genetic lesion, which spontaneously developed a lymphoproliferative autoimmune syndrome exhibiting features of…”
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RasGRP1 Transgenic Mice Develop Cutaneous Squamous Cell Carcinomas in Response to Skin Wounding by Diez, Federico R, Garrido, Ann A, Sharma, Amrish, Luke, Courtney T, Stone, James C, Dower, Nancy A, Cline, J. Mark, Lorenzo, Patricia S

“…Models of epidermal carcinogenesis have demonstrated that Ras is a critical molecule involved in tumor initiation and progression. Previously, we have shown…”
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The role of RasGRPs in regulation of lymphocyte proliferation by Coughlin, Jason J., Stang, Stacey L., Dower, Nancy A., Stone, James C.

“…RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective…”
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Synthetic Bryostatin Analogues Activate the RasGRP1 Signaling Pathway by Stone, James C, Stang, Stacey L, Zheng, Yong, Dower, Nancy A, Brenner, Stacey E, Baryza, Jeremy L, Wender, Paul A

“…The functional properties of four diacylglycerol (DAG) analogues were compared using cell-signaling assays based on the protein RasGRP1, a DAG-regulated Ras…”
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RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic [beta]-Selection and ERK Activation Downstream of CXCR4 by Golec, Dominic P, Dower, Nancy A, Stone, James C, Baldwin, Troy A

“…T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the…”
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Abstract 315: RasGRP1 is a critical link to Ras activation by phorbol esters in mouse epidermal keratinocytes by Sharma, Amrish, Luke, Courtney T., Dower, Nancy A., Stone, James C., Lorenzo, Patricia S.

“…Abstract RasGRP1 is a member of the guanine nucleotide exchange factor family for Ras that binds with high affinity to ultrapotent diacylglycerol analogs like…”
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Liver Transplantation for Prothrombin Deficiency Causing Life-Threatening Bleeds by Dower, Nancy A., McClure, Wilma, Akabutu, John J.

“…We report here the first case of living-related liver transplantation to correct a severe bleeding diathesis. A Caucasian infant was diagnosed at 11 weeks old…”
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CHI MUTATION IN A TRANSPOSON AND THE ORIENTATION-DEPENDENCE OF CHI PHENOTYPE by Yagil, Ezra, Dower, Nancy A, Chattoraj, Dhruba, Stahl, Mary, Pierson, Carey, Stahl, Franklin W

“…Chi, an element that stimulates recombination via the E. coli RecBC pathway, can arise by spontaneous mutation in the transposon Tn5. When in phage lambda in…”
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