Search Results - "Dowall, S"

Emerging viruses and current strategies for vaccine intervention by Afrough, B., Dowall, S., Hewson, R.

“…Summary During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking…”
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A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease by Dowall, SD, Buttigieg, KR, Findlay-Wilson, SJD, Rayner, E, Pearson, G, Miloszewska, A, Graham, VA, Carroll, MW, Hewson, R

“…Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between…”
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A vaccine based on recombinant modified Vaccinia Ankara containing the nucleoprotein from Lassa virus protects against disease progression in a guinea pig model by Kennedy, E.M., Dowall, S.D., Salguero, F.J., Yeates, P., Aram, M., Hewson, R.

“…Lassa fever remains the most imported viral haemorrhagic fever in Europe and is responsible for 5000 deaths per year throughout Western Africa. There is no…”
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Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing by Sharpe, S A, McShane, H, Dennis, M J, Basaraba, R J, Gleeson, F, Hall, G, McIntyre, A, Gooch, K, Clark, S, Beveridge, N E R, Nuth, E, White, A, Marriott, A, Dowall, S, Hill, A V S, Williams, A, Marsh, P D

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Development of an indirect ELISA method for the parallel measurement of IgG and IgM antibodies against Crimean-Congo haemorrhagic fever (CCHF) virus using recombinant nucleoprotein as antigen by Dowall, S.D., Richards, K.S., Graham, V.A., Chamberlain, J., Hewson, R.

“…► ELISA method eliminates the requirement for polyclonal antibodies in the technique. ► Removing IgG is a novel way to prevent its interference in an IgM ELISA…”
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West Nile virus in Tunisia, 2014: First isolation from mosquitoes by Wasfi, F., Dachraoui, K., Cherni, S., Bosworth, A., Barhoumi, W., Dowall, S., Chelbi, I., Derbali, M., Zoghlami, Z., Beier, J.C., Zhioua, E.

“…Irrigation in arid areas of North Africa may lead to the emergence of West Nile virus which is likely to cause future sporadic and foreseeable outbreaks not…”
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Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions by Hewson, R., Bruce, C. B., Schlunegger, K., Empig, C., Corbin-Lickfett, K., Graham, V. A., Dowall, S. D., Easterbrook, L.

“…Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against…”
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Serologic evidence of exposure to Rift Valley fever virus detected in Tunisia by Bosworth, A, Ghabbari, T, Dowall, S, Varghese, A, Fares, W, Hewson, R, Zhioua, E, Chakroun, M, Tiouiri, H, Ben Jemaa, M, Znazen, A, Letaief, A

“…Abstract Rift Valley fever virus (RVFv) is capable of causing dramatic outbreaks amongst economically important animal species and is capable of causing severe…”
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Non-fatal case of Crimean-Congo haemorrhagic fever imported into the United Kingdom (ex Bulgaria), June 2014 by Lumley, S, Atkinson, B, Dowall, Sd, Pitman, Jk, Staplehurst, S, Busuttil, J, Simpson, Aj, Aarons, Ej, Petridou, C, Nijjar, M, Glover, S, Brooks, Tj, Hewson, R

“…Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria in June 2014. The patient developed a moderately…”
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Bunyaviruses in human, animal and mosquito samples from southeast Austria by Huemer, HP, Seidel, B, Hufnagl, P, Deutz, A, Posautz, A, Dowall, S, Hewson, R, Hubalek, Z, Allerberger, F

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Third International Conference on Crimean-Congo Hemorrhagic Fever in Thessaloniki, Greece, September 19–21, 2023 by Welch, Stephen R., Garrison, Aura R., Bente, Dennis A., Burt, Felicity, D'Addiego, Jake, Devignot, Stephanie, Dowall, Stuart, Fischer, Kerstin, Hawman, David W., Hewson, Roger, Mirazimi, Ali, Oestereich, Lisa, Vatansever, Zati, Spengler, Jessica R., Papa, Anna

“…The Third International Conference on Crimean-Congo Hemorrhagic Fever (CCHF) was held in Thessaloniki, Greece, September 19–21, 2023, bringing together a…”
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Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model by Kempster, Sarah, Hassall, Mark, Graham, Victoria, Kennedy, Emma, Findlay-Wilson, Stephen, Salguero, Francisco J., Bagci, Binnur, Elaldi, Nazif, Oz, Murtaza, Tasseten, Tuba, Charlton, Frank W., Barr, John N., Fontana, Juan, Duru, Chinwe, Ezeajughi, Ernest, Matejtschuk, Paul, Arnold, Ulrike, Adedeji, Yemisi, Mirazimi, Ali, Hewson, Roger, Dowall, Stuart, Almond, Neil

“…•Convalescent human plasma can protect against CCHFV challenge in a mouse model.•The protection afforded by the convalescent plasma was titratable.•Defining…”
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Development of a real-time RT-PCR assay for the detection of Crimean-Congo hemorrhagic fever virus by Atkinson, Barry, Chamberlain, John, Logue, Christopher H, Cook, Nicola, Bruce, Christine, Dowall, Stuart D, Hewson, Roger

“…Crimean-Congo hemorrhagic fever (CCHF) is a virulent tick-borne disease with a case fatality rate ranging from 10-50% for tick-borne transmission, and up to…”
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Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target by Neogi, Ujjwal, Elaldi, Nazif, Appelberg, Sofia, Ambikan, Anoop, Kennedy, Emma, Dowall, Stuart, Bagci, Binnur K, Gupta, Soham, Rodriguez, Jimmy E, Svensson-Akusjärvi, Sara, Monteil, Vanessa, Vegvari, Akos, Benfeitas, Rui, Banerjea, Akhil, Weber, Friedemann, Hewson, Roger, Mirazimi, Ali

“…The pathogenesis and host-viral interactions of the Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) are convoluted and not well evaluated. Application…”
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Severe undifferentiated febrile illness outbreaks in the Federal Republic of Sudan – A retrospective epidemiological and diagnostic study by Bower, H., Fletcher, T.E., Mohamed, R., Alzain, M., Elhalawi, A., Osman, A., Semper, A., Brooks, T., Osborne, J., Furneaux, J., Dowall, S., Graham, V., Slack, G., Hewson, R., Beeching, N., Whitworth, J., Bausch, D., Mustafa, M.

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Review of Crimean Congo hemorrhagic fever infection in Kosova in 2008 and 2009: prolonged viremias and virus detected in urine by PCR by Thomas, Sherine, Thomson, Gail, Dowall, Stuart, Bruce, Christina, Cook, Nicola, Easterbrook, Linda, O'Donoghue, Laura, Summers, Sian, Ajazaj, Lindita, Hewson, Roger, Brooks, Tim, Ahmeti, Salih

“…Crimean-Congo hemorrhagic fever (CCHF) is a virus transmitted predominantly by ticks. However, contact with infected body fluids or tissues can result in…”
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Multiplex cytokine profiling with highly pathogenic material: Use of formalin solution in luminex analysis by Dowall, Stuart D., Graham, Victoria A., Tipton, Thomas R.W., Hewson, Roger

“…Work with highly pathogenic material mandates the use of biological containment facilities, involving microbiological safety cabinets and specialist laboratory…”
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Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara by Sharpe, Sally, Hanke, Tomás, Tinsley-Bown, Anne, Dennis, Mike, Dowall, Stuart, McMichael, Andrew, Cranage, Martin

“…Systemically administered DNA encoding a recombinant human immunodeficiency virus (HIV) derived immunogen effectively primes a cytotoxic T lymphocyte (CTL)…”
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Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope by Sharpe, Sally A, Cope, Alethea, Dowall, Stuart, Berry, Neil, Ham, Claire, Heeney, Jonathan L, Hopkins, Donna, Easterbrook, Linda, Dennis, Mike, Almond, Neil, Cranage, Martin

“…1 Health Protection Agency, Porton Down, Salisbury SP4 0JG, UK 2 Division of Retrovirology, National Institute for Biological Standards and Control, South…”
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