Search Results - "Dow, Joan S."

First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model by Kloner, Robert A, Dow, Joan S, Bhandari, Anil

“…There are few safe antiarrhythmics for ischemic heart disease. Whereas ranolazine is a promising late INa blocker with antiarrhythmic effects, and devoid of…”
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Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse by Artaza, Jorge N, Reisz-Porszasz, Suzanne, Dow, Joan S, Kloner, Robert A, Tsao, James, Bhasin, Shalender, Gonzalez-Cadavid, Nestor F

“…Myostatin (Mst) is a negative regulator of skeletal muscle in humans and animals. It is moderately expressed in the heart of sheep and cattle, increasing…”
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Thickening of the infarcted wall by collagen injection improves left ventricular function in rats : A novel approach to preserve cardiac function after myocardial infarction by WANGDE DAI, WOLD, Loren E, DOW, Joan S, KLONER, Robert A

“…We determined whether collagen implantation could thicken the infarcted left ventricular (LV) wall and improve LV function. We hypothesized that thickening the…”
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Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium : Short- and long-term effects by WANGDE DAI, HALE, Sharon L, MARTIN, Bradley J, KUANG, Jin-Qiang, DOW, Joan S, WOLD, Loren E, KLONER, Robert A

“…Mesenchymal stem cells (MSCs) have the potential to replace infarct scar, but the long-term effects are unknown. We studied short- and long-term effects of MSC…”
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Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: A quantitative assessment by Hale, Sharon L., Dai, Wangde, Dow, Joan S., Kloner, Robert A.

“…Ideally, mesenchymal stem cells (MSC) home to and/or remain at the site of damaged myocardium when administered after myocardial infarction. However, MSC may…”
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Survival and Development of Neonatal Rat Cardiomyocytes Transplanted into Adult Myocardium by Müller-Ehmsen, Jochen, Whittaker, Peter, Kloner, Robert A., Dow, Joan S., Sakoda, Tsuyoshi, Long, Tiffany I., Laird, Peter W., Kedes, Larry

“…Transplantation of neonatal cardiomyocytes is a novel approach for the treatment of heart failure and myocardial infarction, but quantitative information on…”
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Stem cell therapy in the heart and vasculature by Wold, Loren E, Dai, Wangde, Dow, Joan S, Kloner, Robert A

“…Stem cell therapy is a progressive approach to a pervasive clinical problem; cardiovascular disease is the number 1 killer in the USA and other developed…”
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Rebuilding a damaged heart: Long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function by MÜLLER-EHMSEN, Jochen, PETERSON, Kirk L, KEDES, Larry, WHITTAKER, Peter, DOW, Joan S, LONG, Tiffany I, LAIRD, Peter W, KLONER, Robert A

“…The long-term effects of cardiac cell transplantation on cardiac function are unknown. Therefore, we tested the survival and functional impact of rat neonatal…”
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The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: through a mechanism favoring inhibition of late sodium channel by Kloner, Robert A, Dow, Joan S, Bhandari, Anil

“…The antianginal agent ranolazine (R) has shown some promise as an antiarrhythmic agent but its mechanism of action is not known. Previously, we have shown that…”
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No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion by REFFELMANN, Thorsten, HALE, Sharon L, DOW, Joan S, KLONER, Robert A

“…No-reflow after reperfusion therapy for myocardial infarction is a strong predictor of clinical outcome. But its fate on a long-term basis and potential…”
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Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias? by Dow, Joan S, Bhandari, Anil, Hale, Sharon L, Kloner, Robert A

“…Whether sex affects the acute phase of myocardial ischemia in experimental animal models is currently being debated. Our purpose was to determine if sex…”
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In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias by Wold, Loren E, Simkhovich, Boris Z, Kleinman, Michael T, Nordlie, Margaret A, Dow, Joan S, Sioutas, Constantinos, Kloner, Robert A

“…Exposure to ultrafine particles (UFPs) by inhalation increases the number and severity of cardiac events. The specific mechanism(s) of action are unknown. This…”
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Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases regional blood flow of infarcted myocardium by Reffelmann, Thorsten, Dow, Joan S., Dai, Wangde, Hale, Sharon L., Simkhovich, Boris Z., Kloner, Robert A.

“…Background. – Cellular cardiomyoplasty is a promising approach for rebuilding scar tissue after acute myocardial infarction. However, the angiogenic potential…”
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Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function by Yao, Mu, Dieterle, Thomas, Hale, Sharon L., Dow, Joan S., Kedes, Laurence H., Peterson, Kirk L., Kloner, Robert A.

“…Objectives. – The purpose of this study was to determine the long-term outcome of fetal cell transplantation into myocardial infarction on left ventricular…”
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Development of abnormal tissue architecture in transplanted neonatal rat myocytes by Whittaker, Peter, Müller-Ehmsen, Jochen, Dow, Joan S, Kedes, Larry H, Kloner, Robert A

“…Most myocardial cell transplant studies focus on demonstration of improved function; however, such improvement depends on the development of appropriate tissue…”
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Long-term beneficial effects of neonatal cardiomyocytes on left ventricular ejection fraction, regional wall motion, and scar thickness after transplantation into infarcted rat hearts by Muller-Ehmsen, Jochen, Peterson, Kirk L., Kedes, Larry, Whittaker, Peter, Dow, Joan S., Kloner, Robert A.

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Stem cell therapy for the heart by Wold, Loren E, Dai, Wangde, Sesti, Casilde, Hale, Sharon L, Dow, Joan S, Martin, Bradley J, Kloner, Robert A

“…Cellular cardiomyoplasty is an expanding field of research that involves numerous types of immature cells administered via several modes of delivery. The…”
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Can Moderate Alcohol Intake Limit the Size of Myocardial Infarction? by Dow, Joan S, Hale, Sharon L, Kloner, Robert A

“…Several observational and epidemiologic analyses suggest that moderate drinking of alcohol (usually two drinks per day) may have beneficial effects on the…”
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Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats by Dai, Wangde, Wold, Loren E., Dow, Joan S., Kloner, Robert A.

“…We determined whether collagen implantation could thicken the infarcted left ventricular (LV) wall and improve LV function. We hypothesized that thickening the…”
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