Search Results - "Dow, Geoffrey S."

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine by Wipf, Peter, Mo, Tingting, Geib, Steven J, Caridha, Diana, Dow, Geoffrey S, Gerena, Lucia, Roncal, Norma, Milner, Erin E

“…Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and…”
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Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta) by Dow, Geoffrey S, Gettayacamin, Montip, Hansukjariya, Pranee, Imerbsin, Rawiwan, Komcharoen, Srawuth, Sattabongkot, Jetsumon, Kyle, Dennis, Milhous, Wilbur, Cozens, Simon, Kenworthy, David, Miller, Anne, Veazey, Jim, Ohrt, Colin

“…Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the…”
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Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors by DOW, Geoffrey S, YUFENG CHEN, TRAN, Thanh N, KOZIKOWSKI, Alan P, ANDREWS, Katherine T, CARIDHA, Diana, GERENA, Lucia, GETTAYACAMIN, Montip, JOHNSON, Jacob, QIGUI LI, MELENDEZ, Victor, OBALDIA, Nicanor

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Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice by Dow, Geoffrey S, Milner, Erin, Bathurst, Ian, Bhonsle, Jayendra, Caridha, Diana, Gardner, Sean, Gerena, Lucia, Kozar, Michael, Lanteri, Charlotte, Mannila, Anne, McCalmont, William, Moon, Jay, Read, Kevin D, Norval, Suzanne, Roncal, Norma, Shackleford, David M, Sousa, Jason, Steuten, Jessica, White, Karen L, Zeng, Qiang, Charman, Susan A

“…The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in…”
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Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki by Dow, Geoffrey S, Magill, Alan J, Ohrt, Colin

“…Malaria is of continuing concern in nonimmune traveling populations. Traditionally, antimalarial drugs have been developed as agents for dual indications…”
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The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains by DOW, Geoffrey S, KOENIG, Michael L, WOLF, Lesley, GERENA, Lucia, LOPEZ-SANCHEZ, Miriam, HUDSON, Thomas H, BHATTACHARJEE, Apurba K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells and Plasmodium falciparum by Chen, Yufeng, Lopez-Sanchez, Miriam, Savoy, Doris N, Billadeau, Daniel D, Dow, Geoffrey S, Kozikowski, Alan P

“…The discovery of the rules governing the inhibition of the various HDAC isoforms is likely to be key to identifying improved therapeutics that act as…”
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Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine by Mo, Tingting, Mi, Xueling, Milner, Erin E., Dow, Geoffrey S., Wipf, Peter

“…The 8-SF 5 analog of mefloquine was synthesized in nine steps from commercially available starting materials and in five steps from a novel ortho-SF…”
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Summary of anti-malarial prophylactic efficacy of tafenoquine from three placebo-controlled studies of residents of malaria-endemic countries by Dow, Geoffrey S, Liu, Jun, Lin, Gina, Hetzell, Brian, Thieling, Sarah, McCarthy, William F, Tang, Douglas, Smith, Bryan

“…Tafenoquine is a long half-life primaquine analog being developed for malaria prophylaxis. The US Army recently performed a unified analysis of efficacy in…”
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Tafenoquine is not neurotoxic following supertherapeutic dosing in rats by Dow, Geoffrey S, Brown, Tracey, Reid, Mark, Smith, Bryan, Toovey, Stephen

“…Abstract Background Tafenoquine is a new drug for malaria prevention. The goal of the present work was to conduct a specific neurobehavioral study in rats with…”
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A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area by Dow, Geoffrey S, McCarthy, William F, Reid, Mark, Smith, Bryan, Tang, Douglas, Shanks, G Dennis

“…In 2000/2001, the Australian Defense Forces (ADF), in collaboration with SmithKline Beecham and the United States Army, conducted a field trial to evaluate the…”
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Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model by Obaldía III, Nicanor, Dow, Geoffrey S., Gerena, Lucia, Kyle, Dennis, Otero, William, Mantel, Pierre-Yves, Baro, Nicholas, Daniels, Rachel, Mukherjee, Angana, Childs, Lauren M., Buckee, Caroline, Duraisingh, Manoj T., Volkman, Sarah K., Wirth, Dyann F., Marti, Matthias

“…Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based…”
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A Planned Trial to Evaluate the Safety and Efficacy of Tafenoquine + Atovaquone/Azithromycin in Hospitalized Patients With Babesiosis by Dow, Geoffrey S, Smith, Bryan

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Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy by Milner, Erin, Sousa, Jason, Pybus, Brandon, Auschwitz, Jennifer, Caridha, Diana, Gardner, Sean, Grauer, Kristina, Harris, Erin, Hickman, Mark, Kozar, Michael P., Lee, Patricia, Leed, Susan, Li, Qigui, Melendez, Victor, Moon, Jay, Ngundam, Franklyn, O’Neil, Michael, Parriott, Sandi, Potter, Brittney, Sciotti, Rick, Tangteung, Anchalee, Dow, Geoffrey S.

“…Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models. However, the low plasma levels and short half life of the drug do not…”
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Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro by Dow, Geoffrey S., Caridha, Diana, Goldberg, Michelle, Wolf, Lesley, Koenig, Michael L., Yourick, Debra L., Wang, Zhining

“…Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine…”
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Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine by Dow, Geoffrey S

“…There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using…”
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The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro by Dow, Geoffrey S, Hudson, Thomas H, Vahey, Maryanne, Koenig, Michael L

“…There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of…”
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Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki by Geoffrey S Dow, Alan J Magill, Colin Ohrt

“…Geoffrey S Dow, Alan J Magill, Colin OhrtDivision of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD, USAAbstract: Malaria…”
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Transcriptional profiling of mefloquine-induced dismption of calcium homeostasis in neurons in vitro by DOW, Geoffrey S, CARIDHA, Diana, GOLDBERG, Michelle, WOLF, Lesley, KOENIG, Michael L, YOURICK, Debra L, ZHINING WANG

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Plasmodium berghei: In VivoEfficacy of Albendazole in Different Rodent Models by Dow, Geoffrey S., Reynoldson, James A., Andrew Thompson, R.C.

“…Dow, G. S., Reynoldson, J. A., and Thompson, R. C. A. 1998.Plasmodium berghei: In vivoefficacy of albendazole in different rodent models.Experimental…”
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