Search Results - "Dove, L. S."

The outer membrane protein, Antigen 43, mediates cell‐to‐cell interactions within Escherichia coli biofilms by Danese, Paul N., Pratt, Leslie A., Dove, Simon L., Kolter, Roberto

“…Transcription of the agn43 locus, which specifies an outer membrane protein of Escherichia coli, is regulated in a phase‐variable fashion by the OxyR–DNA…”
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Early response predicts a sustained response to eluxadoline in patients with irritable bowel syndrome with diarrhoea in two Phase 3 studies by Chey, W. D., Dove, L. S., Andrae, D. A., Covington, P. S.

“…Summary Background The mixed μ‐ and κ‐opioid receptor agonist and δ‐opioid receptor antagonist, eluxadoline, is licensed in the USA for the treatment of…”
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Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target by Dove, S L, Hochschild, A

“…Evidence obtained in both eukaryotes and prokaryotes indicates that arbitrary contacts between DNA-bound proteins and components of the transcriptional…”
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Activation of prokaryotic transcription through arbitrary protein-protein contacts by Dove, Simon L, Joung, J. Keith, Hochschild, Ann

“…Many transcriptional activators in prokaryotes are known to bind near a promoter and contact RNA polymerase, but it is not clear whether a protein-protein…”
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Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist by Levy-Cooperman, N, McIntyre, G, Bonifacio, L, McDonnell, M, Davenport, J M, Covington, P S, Dove, L S, Sellers, E M

“…Drugs with μ-opioid receptor (OR) activity can be associated with abuse and misuse. The peripherally acting mixed μ-OR and κ-OR agonist and δ-OR antagonist…”
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Radar plots: A novel modality for displaying disparate data on the efficacy of eluxadoline for the treatment of irritable bowel syndrome with diarrhea by Brenner, D. M., Dove, L. S., Andrae, D. A., Covington, P. S., Gutman, C., Chey, W. D.

“…Background Patients with irritable bowel syndrome with diarrhea (IBS‐D) experience a range of abdominal and bowel symptoms; successful management requires…”
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Magnitude of the CREB-Dependent Transcriptional Response Is Determined by the Strength of the Interaction between the Kinase-Inducible Domain of CREB and the KIX Domain of CREB-Binding Protein by Shaywitz, Adam J., Dove, Simon L., Kornhauser, Jon M., Hochschild, Ann, Greenberg, Michael E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Region 4 of σ as a target for transcription regulation by Dove, Simon L., Darst, Seth A., Hochschild, Ann

“…Summary Bacterial σ factors play a key role in promoter recognition, making direct contact with conserved promoter elements. Most σ factors belong to the σ70…”
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A Role for Interaction of the RNA Polymerase Flap Domain with the σ Subunit in Promoter Recognition by Kuznedelov, Konstantin, Minakhin, Leonid, Niedziela-Majka, Anita, Dove, Simon L., Rogulja, Dragana, Nickels, Bryce E., Hochschild, Ann, Heyduk, Tomasz, Severinov, Konstantin

“…In bacteria, promoter recognition depends on the RNA polymerase σ subunit, which combines with the catalytically proficient RNA polymerase core to form the…”
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RshA, an anti‐sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH by Song, Taeksun, Dove, Simon L., Lee, Kon Ho, Husson, Robert N.

“…Summary SigH, an alternative sigma factor of Mycobacterium tuberculosis,  is  a  central regulator  of  the  response to oxidative and heat stress. Exposure to…”
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Use of artificial activators to define a role for protein-protein and protein-DNA contacts in transcriptional activation by Dove, S L, Hochschild, A

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Protein–Protein Contacts that Activate and Repress Prokaryotic Transcription by Hochschild, Ann, Dove, Simon L

“…Many prokaryotic activators and repressors contact RNA polymerase (RNAP) directly, and this minreview focuses on recent work that illuminates the mechanistic…”
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Bacterial two-hybrid analysis of interactions between region 4 of the sigma(70) subunit of RNA polymerase and the transcriptional regulators Rsd from Escherichia coli and AlgQ from Pseudomonas aeruginosa by Dove, S L, Hochschild, A

“…A number of transcriptional regulators mediate their effects through direct contact with the sigma(70) subunit of Escherichia coli RNA polymerase (RNAP). In…”
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Whole-Cell and Single-Channel Analysis of P-Type Calcium Currents in Cerebellar Purkinje Cells of Leaner Mutant Mice by Dove, Leonard S, Abbott, Louise C, Griffith, William H

“…The leaner (tgla) mutation in mice results in severe ataxia and an overt neurodegeneration of the cerebellum. Positional cloning has revealed that the tgla…”
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Isolation of Peptide Aptamers That Inhibit Intracellular Processes by Blum, Jonathan H., Dove, Simon L., Hochschild, Ann, Mekalanos, John J.

“…We have developed a method for isolation of random peptides that inhibit intracellular processes in bacteria. A library of random peptides expressed as fusions…”
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Mechanism for a Transcriptional Activator That Works at the Isomerization Step by Dove, Simon L., Huang, Franklin W., Hochschild, Ann

“…Transcriptional activators in prokaryotes have been shown to stimulate different steps in the initiation process including the initial binding of RNA…”
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An RNA Polymerase Mutant Deficient in DNA Melting Facilitates Study of Activation Mechanism: Application to an Artificial Activator of Transcription by Sun, Li, Dove, Simon L., Panaghie, Gianina, deHaseth, Pieter L., Hochschild, Ann

“…Transcription initiation is a major target for the regulation of gene expression in all organisms. Transcription activators can stimulate different steps in…”
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Altered Calcium Homeostasis in Cerebellar Purkinje Cells of Leaner Mutant Mice by Dove, Leonard S, Nahm, Sang-Soep, Murchison, David, Abbott, Louise C, Griffith, William H

“…  1 Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A&M University System Health Science Center, College Station 77843-1114; and…”
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Cutaneous Findings in Mummies from the British Museum by Leslie, K S, Levell, N J, Dove, S L B

“…This paper describes pathological abnormalities visible on the skin of mummies in the British Museum, London, and the photographic methods used to record their…”
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Control of Escherichia coli type 1 fimbrial gene expression in stationary phase: a negative role for RpoS by Dove, S L, Smith, S G, Dorman, C J

“…Expression of type 1 fimbriae in Escherichia coli is subject to phase-dependent control, with many regulatory inputs from proteins which organise or rearrange…”
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