Search Results - "Dovat, Sinisa"

New precision medicine weapons for targeted treatment of high-risk B-cell precursor acute lymphoblastic leukemia by Dovat, Sinisa, Schramm, Joseph

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RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1 by Elcheva, Irina A., Wood, Tyler, Chiarolanzio, Kathryn, Chim, Bryan, Wong, Madeline, Singh, Vikash, Gowda, Chethana P., Lu, Qingli, Hafner, Markus, Dovat, Sinisa, Liu, Zhenqiu, Muljo, Stefan A., Spiegelman, Vladimir S.

“…Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we…”
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Correction: Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia by Guo, Xing, Zhang, Run, Liu, Juan, Li, Min, Song, Chunhua, Dovat, Sinisa, Li, Jianyong, Ge, Zheng

“…[This corrects the article DOI: 10.1371/journal.pone.0125429.]…”
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Medulloblastoma: “Onset of the molecular era” by Dhanyamraju, Pavan Kumar, Patel, Trupti N., Dovat, Sinisa

“…Among brain tumors, Medulloblastoma (MB) is one of the most common, malignant, pediatric tumors of the cerebellum. It accounts for ~20% of all childhood…”
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Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity by Raca, Gordana, Abdel-Azim, Hisham, Yue, Feng, Broach, James, Payne, Jonathon L., Reeves, Mark E., Gowda, Chandrika, Schramm, Joseph, Desai, Dhimant, Dovat, Elanora, Hu, Tommy, Berg, Arthur S., Bhojwani, Deepa, Payne, Kimberly J., Dovat, Sinisa

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Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity by Ding, Yali, Zhang, Bo, Payne, Jonathon L., Song, Chunhua, Ge, Zheng, Gowda, Chandrika, Iyer, Soumya, Dhanyamraju, Pavan K., Dorsam, Glenn, Reeves, Mark E., Desai, Dhimant, Huang, Suming, Payne, Kimberly J., Yue, Feng, Dovat, Sinisa

“…Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros…”
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Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia by Guo, Xing, Zhang, Run, Liu, Juan, Li, Min, Song, Chunhua, Dovat, Sinisa, Li, Jianyong, Ge, Zheng

“…Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL)…”
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Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy by Chen, Shu-jen, Bao, Lei, Keefer, Kerry, Shanmughapriya, Santhanam, Chen, Longgui, Lee, John, Wang, JuFang, Zhang, Xue-Qian, Hirschler-Laszkiewicz, Iwona, Merali, Salim, Merali, Carmen, Imamura, Yuka, Dovat, Sinisa, Madesh, Muniswamy, Cheung, Joseph Y., Wang, Hong-Gang, Miller, Barbara A.

“…Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in maintaining cell survival following oxidant injury. Here, we show…”
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IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment by Elcheva, Irina A, Gowda, Chethana P, Bogush, Daniel, Gornostaeva, Svetlana, Fakhardo, Anna, Sheth, Neil, Kokolus, Kathleen M, Sharma, Arati, Dovat, Sinisa, Uzun, Yasin, Schell, Todd D, Spiegelman, Vladimir S

“…Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the…”
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P344: ONCOGENESIS OF CRLF2 OVEREXPRESSION AND EFFECT OF A NOVEL JAK2 INHIBITOR IN CRLF2 OVEREXPRESSED B‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA by Gu, Yan, Song, Chunhua, Dovat, Sinisa, Ge, Zheng

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Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia by Gu, Siyu, Hou, Yue, Dovat, Katarina, Dovat, Sinisa, Song, Chunhua, Ge, Zheng

“…More effective targeted therapy and new combination regimens are needed for Acute myeloid leukemia (AML), owing to the unsatisfactory long-term prognosis of…”
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Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies by Gowda, Chandrika, Sachdev, Mansi, Muthusami, Sunil, Kapadia, Malika, Petrovic-Dovat, Lidija, Hartman, Melanie, Ding, Yali, Song, Chunhua, Payne, Jonathon L, Tan, Bi-Hua, Dovat, Sinisa

“…Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a promising therapeutic target in cancer. Recent studies have revealed an important…”
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Therapeutic Benefits of Selenium in Hematological Malignancies by Ehudin, Melanie A., Golla, Upendarrao, Trivedi, Devnah, Potlakayala, Shobha D., Rudrabhatla, Sairam V., Desai, Dhimant, Dovat, Sinisa, Claxton, David, Sharma, Arati

“…Supplementing chemotherapy and radiotherapy with selenium has been shown to have benefits against various cancers. This approach has also been shown to…”
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PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells by Nicolae, Claudia M., O’Connor, Michael J., Schleicher, Emily M., Song, Chunhua, Gowda, Raghavendra, Robertson, Gavin, Dovat, Sinisa, Moldovan, George-Lucian

“…Hyperproliferative cancer cells face increased replication stress, which can result in accumulation of DNA damage. As DNA damage can arrest proliferation, and,…”
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PB1784: CLADRIBINE SYNERGIZES THE EFFECT OF VENETOCLAX ON CELL PROLIFERATION ARREST AND APOPTOSIS BY TARGETING DNA‐PKCS/C‐MYC SIGNALING IN ACUTE MYELOID LEUKEMIA by Hou, Yue, Dovat, Katarina, Dovat, Sinisa, Song, Chunhua, Ge, Zheng

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TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia by Alkashgari, Hossam R, Ruiz-Jimenez, Caleb, Stoian, Cornelia, Coats, Jacqueline S, Baez, Ineavely, Chirshev, Evgeny, Martinez, Shannalee R, Dovat, Sinisa, Francis-Boyle, Olivia L, Casiano, Carlos A, Payne, Kimberly J

“…Cytokine receptor-like factor 2 B-cell acute lymphoblastic leukemia (CRLF2 B-ALL) is a high-risk subtype characterized by CRLF2 overexpression with poor…”
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Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia by Wang, Haijun, Song, Chunhua, Ding, Yali, Pan, Xiaokang, Ge, Zheng, Tan, Bi-Hua, Gowda, Chandrika, Sachdev, Mansi, Muthusami, Sunil, Ouyang, Hongsheng, Lai, Liangxue, Francis, Olivia L., Morris, Christopher L., Abdel-Azim, Hisham, Dorsam, Glenn, Xiang, Meixian, Payne, Kimberly J., Dovat, Sinisa

“…Impaired function of the Ikaros (IKZF1) protein is associated with the development of high-risk B-cell precursor acute lymphoblastic leukemia (B-ALL). The…”
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Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia by Ge, Zheng, Song, Chunhua, Ding, Yali, Tan, Bi-Hua, Desai, Dhimant, Sharma, Arati, Gowda, Raghavendra, Yue, Feng, Huang, Suming, Spiegelman, Vladimir, Payne, Jonathon L., Reeves, Mark E., Iyer, Soumya, Dhanyamraju, Pavan Kumar, Imamura, Yuka, Bogush, Daniel, Bamme, Yevgeniya, Yang, Yiping, Soliman, Mario, Kane, Shriya, Dovat, Elanora, Schramm, Joseph, Hu, Tommy, McGrath, Mary, Chroneos, Zissis C., Payne, Kimberly J., Gowda, Chandrika, Dovat, Sinisa

“…Children of Hispanic/Latino ancestry have increased incidence of high-risk B-cell acute lymphoblastic leukemia (HR B-ALL) with poor prognosis. This leukemia is…”
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Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro by Chen, William A, Williams, Terry G, So, Leena, Drew, Natalie, Fang, Jie, Ochoa, Pedro, Nguyen, Nhi, Jawhar, Yasmeen, Otiji, Jide, Duerksen-Hughes, Penelope J, Reeves, Mark E, Casiano, Carlos A, Jin, Hongjian, Dovat, Sinisa, Yang, Jun, Boyle, Kristopher E, Francis-Boyle, Olivia L

“…Acute myeloid leukemia (AML) is a hematological malignancy that is characterized by an expansion of immature myeloid precursors. Despite therapeutic advances,…”
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The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia by Annageldiyev, Charyguly, Gowda, Krishne, Patel, Trupti, Bhattacharya, Priyanjali, Tan, Su-Fern, Iyer, Soumya, Desai, Dhimant, Dovat, Sinisa, Feith, David J, Loughran, Jr, Thomas P, Amin, Shantu, Claxton, David, Sharma, Arati

“…Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments…”
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