Search Results - "Doutch, James"

Effect of Formulation Method, Lipid Composition, and PEGylation on Vesicle Lamellarity: A Small-Angle Neutron Scattering Study by Nele, Valeria, Holme, Margaret N, Kauscher, Ulrike, Thomas, Michael R, Doutch, James J, Stevens, Molly M

“…Liposomes are well-established systems for drug delivery and biosensing applications. The design of a liposomal carrier requires careful choice of lipid…”
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Long-Range Electrostatic Colloidal Interactions and Specific Ion Effects in Deep Eutectic Solvents by Sanchez-Fernandez, Adrian, Jackson, Andrew J, Prévost, Sylvain F, Doutch, James J, Edler, Karen J

“…While the traditional consensus dictates that high ion concentrations lead to negligible long-range electrostatic interactions, we demonstrate that…”
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Ultrasound‐Triggered Enzymatic Gelation by Nele, Valeria, Schutt, Carolyn E., Wojciechowski, Jonathan P., Kit‐Anan, Worrapong, Doutch, James J., Armstrong, James P. K., Stevens, Molly M.

“…Hydrogels are formed using various triggers, including light irradiation, pH adjustment, heating, cooling, or chemical addition. Here, a new method for forming…”
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Self-Assembly of Soluplus in Aqueous Solutions: Characterization and Prospectives on Perfume Encapsulation by Sofroniou, Constantina, Baglioni, Michele, Mamusa, Marianna, Resta, Claudio, Doutch, James, Smets, Johan, Baglioni, Piero

“…Soluplus is an amphiphilic graft copolymer intensively studied as a micellar solubilizer for drugs. An extensive characterization of the nanostructure of its…”
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Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment by Ghosh, Dipankar, Coulter, Sophie M., Laverty, Garry, Holland, Chris, Doutch, James J., Vassalli, Massimo, Adams, Dave J.

“…Achieving precise control over gelator alignment and morphology is crucial for crafting tailored materials and supramolecular structures with distinct…”
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Surface Dynamics and Ligand–Core Interactions of Quantum Sized Photoluminescent Gold Nanoclusters by Lin, Yiyang, Charchar, Patrick, Christofferson, Andrew J, Thomas, Michael R, Todorova, Nevena, Mazo, Manuel M, Chen, Qu, Doutch, James, Richardson, Robert, Yarovsky, Irene, Stevens, Molly M

“…Quantum-sized metallic clusters protected by biological ligands represent a new class of luminescent materials; yet the understanding of structural information…”
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Morphology Modulation of Ionic Surfactant Micelles in Ternary Deep Eutectic Solvents by Atri, Ria S, Sanchez-Fernandez, Adrian, Hammond, Oliver S, Manasi, Iva, Doutch, James, Tellam, James P, Edler, Karen J

“…Deep eutectic solvents (DES) are potentially greener solvents obtained through the complexation of simple precursors which, among other applications, have been…”
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Beamline B21: high‐throughput small‐angle X‐ray scattering at Diamond Light Source by Cowieson, Nathan P., Edwards-Gayle, Charlotte J. C., Inoue, Katsuaki, Khunti, Nikul S., Doutch, James, Williams, Eugene, Daniels, Steven, Preece, Geoff, Krumpa, Nicholas A., Sutter, John P., Tully, Mark D., Terrill, Nick J., Rambo, Robert P.

“…B21 is a small‐angle X‐ray scattering (SAXS) beamline with a bending magnet source in the 3 GeV storage ring at the Diamond Light Source Ltd synchrotron in the…”
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Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases by Pinkas, Daniel M, Sanvitale, Caroline E, Bufton, Joshua C, Sorrell, Fiona J, Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N

“…Members of the potassium channel tetramerization domain (KCTD) family are soluble non-channel proteins that commonly function as Cullin3 (Cul3)-dependent E3…”
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Ultraviolet Light Transmission through the Human Corneal Stroma Is Reduced in the Periphery by Doutch, James J., Quantock, Andrew J., Joyce, Nancy C., Meek, Keith M.

“…This article investigates in vitro light transmission through the human cornea in the ultraviolet (UV) portion of the electromagnetic spectrum as a function of…”
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Drying Affects the Fiber Network in Low Molecular Weight Hydrogels by Mears, Laura L. E, Draper, Emily R, Castilla, Ana M, Su, Hao, Zhuola, Dietrich, Bart, Nolan, Michael C, Smith, Gregory N, Doutch, James, Rogers, Sarah, Akhtar, Riaz, Cui, Honggang, Adams, Dave J

“…Low molecular weight gels are formed by the self-assembly of a suitable small molecule gelator into a three-dimensional network of fibrous structures. The gel…”
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Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4 by Spiteri, Valentina A, Doutch, James, Rambo, Robert P, Bhatt, Jayesh S, Gor, Jayesh, Dalby, Paul A, Perkins, Stephen J

“…Human immunoglobulin G (IgG) exists as four subclasses IgG1-4, each of which has two Fab subunits joined by two hinges to a Fc subunit. IgG4 has the shortest…”
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Coupling Lipid Nanoparticle Structure and Automated Single‐Particle Composition Analysis to Design Phospholipase‐Responsive Nanocarriers by Barriga, Hanna M. G., Pence, Isaac J., Holme, Margaret N., Doutch, James J., Penders, Jelle, Nele, Valeria, Thomas, Michael R., Carroni, Marta, Stevens, Molly M.

“…Lipid nanoparticles (LNPs) are versatile structures with tunable physicochemical properties that are ideally suited as a platform for vaccine delivery and RNA…”
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Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127 by Constantinou, Anna P, Nele, Valeria, Doutch, James J, S. Correia, Joana, Moiseev, Roman V, Cihova, Martina, Gaboriau, David C. A, Krell, Jonathan, Khutoryanskiy, Vitaliy V, Stevens, Molly M, Georgiou, Theoni K

“…Thermoresponsive polymers with the appropriate structure form physical networks upon changes in temperature, and they find utility in formulation science,…”
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Controlled Dendrimersome Nanoreactor System for Localized Hypochlorite-Induced Killing of Bacteria by Potter, Michael, Najer, Adrian, Klöckner, Anna, Zhang, Shaodong, Holme, Margaret N, Nele, Valeria, Che, Junyi, Massi, Lucia, Penders, Jelle, Saunders, Catherine, Doutch, James J, Edwards, Andrew M, Ces, Oscar, Stevens, Molly M

“…Antibiotic resistance is a serious global health problem necessitating new bactericidal approaches such as nanomedicines. Dendrimersomes (DSs) have recently…”
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Revealing Population Heterogeneity in Vesicle-Based Nanomedicines Using Automated, Single Particle Raman Analysis by Saunders, Catherine, Foote, James E. J., Wojciechowski, Jonathan P., Cammack, Ana, Pedersen, Simon V., Doutch, James J., Barriga, Hanna M. G., Holme, Margaret N., Penders, Jelle, Chami, Mohamed, Najer, Adrian, Stevens, Molly M.

“…The intrinsic heterogeneity of many nanoformulations is currently challenging to characterize on both the single particle and population level. Therefore,…”
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Tuneable peptide cross-linked nanogels for enzyme-triggered protein delivery by Massi, Lucia, Najer, Adrian, Chapman, Robert, Spicer, Christopher D, Nele, Valeria, Che, Junyi, Booth, Marsilea A, Doutch, James J, Stevens, Molly M

“…Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug…”
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Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand by Morrison, Kerrie A., Wood, Laura, Edler, Karen J., Doutch, James, Price, Gareth J., Koumanov, Francoise, Whitley, Paul

“…Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of…”
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Design of Lipid-Based Nanocarriers via Cation Modulation of Ethanol-Interdigitated Lipid Membranes by Nele, Valeria, Holme, Margaret N, Rashid, M. Harunur, Barriga, Hanna M. G, Le, Tu C, Thomas, Michael R, Doutch, James J, Yarovsky, Irene, Stevens, Molly M

“…Short-chain alcohols (i.e., ethanol) can induce membrane interdigitation in saturated-chain phosphatidylcholines (PCs). In this process, alcohol molecules…”
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Self‐Assembling Anti‐Freezing Lamellar Nanostructures in Subzero Temperatures by Yin, Hongyao, Guo, Weiluo, Wang, Runxi, Doutch, James, Li, Peixun, Tian, Qiang, Zheng, Zhuo, Xie, Lingzhi, Feng, Yujun

“…The requirement for cryogenic supramolecular self‐assembly of amphiphiles in subzero environments is a challenging topic. Here, the self‐assembly of lamellar…”
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