CD8+ T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity

•CD8+ T cells play a major role in brain plasticity induced by enriched environment.•Peripheral CD8+ T cells have different properties in mice raised in EE vs. SE.•Spleen & brain CD8+ T cell repartition of effector/central memory CD8+ T cells differ.•Brain & peripheral CD8+ T cell have diffe...

Full description

Saved in:

Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 69; pp. 235 - 254
Main Authors:	Zarif, Hadi, Nicolas, Sarah, Guyot, Mélanie, Hosseiny, Salma, Lazzari, Anne, Canali, María Magdalena, Cazareth, Julie, Brau, Frédéric, Golzné, Valentine, Dourneau, Elisa, Maillaut, Maud, Luci, Carmelo, Paquet, Agnès, Lebrigand, Kevin, Arguel, Marie-Jeanne, Daoudlarian, Douglas, Heurteaux, Catherine, Glaichenhaus, Nicolas, Chabry, Joëlle, Guyon, Alice, Petit-Paitel, Agnès
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-03-2018 Elsevier
Subjects:	Behavior Brain plasticity CD8+ T cells Choroid plexus Enriched environment Hippocampus Life Sciences Long term potentiation Mice Neurobiology Neurogenesis Neurons and Cognition Synaptogenesis Choroid plexus CD8+ T cells Brain plasticity Synaptogenesis Long term potentiation Mice Behavior Neurogenesis Hippocampus Enriched environment CD8(+) T cells mice, brain plasticity, hippocampus, CD4 + T cells, enriched environment
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	•CD8+ T cells play a major role in brain plasticity induced by enriched environment.•Peripheral CD8+ T cells have different properties in mice raised in EE vs. SE.•Spleen & brain CD8+ T cell repartition of effector/central memory CD8+ T cells differ.•Brain & peripheral CD8+ T cell have different transcriptomic signatures in EE vs. SE. Enriched environment (EE) induces plasticity changes in the brain. Recently, CD4+ T cells have been shown to be involved in brain plasticity processes. Here, we show that CD8+ T cells are required for EE-induced brain plasticity in mice, as revealed by measurements of hippocampal volume, neurogenesis in the DG of the hippocampus, spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. As a consequence, EE-induced behavioral benefits depend, at least in part, on CD8+ T cells. In addition, we show that spleen CD8+ T cells from mice housed in standard environment (SE) and EE have different properties in terms of 1) TNFα release after in vitro CD3/CD28 or PMA/Iono stimulation 2) in vitro proliferation properties 3) CD8+ CD44+ CD62Llow and CD62Lhi T cells repartition 4) transcriptomic signature as revealed by RNA sequencing. CD8+ T cells purified from the choroid plexus of SE and EE mice also exhibit different transcriptomic profiles as highlighted by single-cell mRNA sequencing. We show that CD8+ T cells are essential mediators of beneficial EE effects on brain plasticity and cognition. Additionally, we propose that EE differentially primes CD8+ T cells leading to behavioral improvement.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2017.11.016