Search Results - "Dourlen, Pierre"

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? by Dourlen, Pierre, Kilinc, Devrim, Malmanche, Nicolas, Chapuis, Julien, Lambert, Jean-Charles

“…A strong genetic predisposition (60–80% of attributable risk) is present in Alzheimer’s disease (AD). In view of this major genetic component, identification…”
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Fatty acid transport proteins in disease: New insights from invertebrate models by Dourlen, Pierre, Sujkowski, Alyson, Wessells, Robert, Mollereau, Bertrand

“…The dysregulation of lipid metabolism has been implicated in various diseases, including diabetes, cardiopathies, dermopathies, retinal and neurodegenerative…”
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ER stress inhibits neuronal death by promoting autophagy by Fouillet, Antoine, Levet, Clemence, Virgone, Angelique, Robin, Marion, Dourlen, Pierre, Rieusset, Jennifer, Belaidi, Elise, Ovize, Michel, Touret, Monique, Nataf, Serge, Mollereau, Bertrand

“…Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases but its relationship and role in disease progression remain unclear. Using…”
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Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina by Van Den Brink, Daan M, Cubizolle, Aurélie, Chatelain, Gilles, Davoust, Nathalie, Girard, Victor, Johansen, Simone, Napoletano, Francesco, Dourlen, Pierre, Guillou, Laurent, Angebault-Prouteau, Claire, Bernoud-Hubac, Nathalie, Guichardant, Michel, Brabet, Philippe, Mollereau, Bertrand

“…Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular…”
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Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila by Gambis, Alexis, Dourlen, Pierre, Steller, Hermann, Mollereau, Bertrand

“…We report a new two-color fluorescent imaging system to visualize the mosaic adult photoreceptor neurons (PRs) in real-time. Using this method, we examined a…”
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The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects by Lambert, Erwan, Saha, Orthis, Soares Landeira, Bruna, Melo de Farias, Ana Raquel, Hermant, Xavier, Carrier, Arnaud, Pelletier, Alexandre, Gadaut, Johanna, Davoine, Lindsay, Dupont, Cloé, Amouyel, Philippe, Bonnefond, Amélie, Lafont, Frank, Abdelfettah, Farida, Verstreken, Patrik, Chapuis, Julien, Barois, Nicolas, Delahaye, Fabien, Dermaut, Bart, Lambert, Jean-Charles, Costa, Marcos R, Dourlen, Pierre

“…The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer's disease (AD). Deciphering its pathophysiological role is challenging due…”
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Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival by Dourlen, Pierre, Bertin, Benjamin, Chatelain, Gilles, Robin, Marion, Napoletano, Francesco, Roux, Michel J, Mollereau, Bertrand

“…Tight regulation of the visual response is essential for photoreceptor function and survival. Visual response dysregulation often leads to photoreceptor cell…”
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TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila by Vanden Broeck, Lies, Naval-Sánchez, Marina, Adachi, Yoshitsugu, Diaper, Danielle, Dourlen, Pierre, Chapuis, Julien, Kleinberger, Gernot, Gistelinck, Marc, Van Broeckhoven, Christine, Lambert, Jean-Charles, Hirth, Frank, Aerts, Stein, Callaerts, Patrick, Dermaut, Bart

“…TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43…”
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Identification of Tau Toxicity Modifiers in the Drosophila Eye by Dourlen, Pierre

“…Drosophila is a powerful model to study human diseases thanks to its genetic tools and ease of screening. Human genes can be expressed in targeted organs and…”
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Drosophila Models of Tauopathies : What Have We Learned? by Gistelinck, Marc, Lambert, Jean-Charles, Callaerts, Patrick, Dermaut, Bart, Dourlen, Pierre

“…Aggregates of the microtubule-associated protein Tau are neuropathological hallmark lesions in Alzheimer's disease (AD) and related primary tauopathies. In…”
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Identification of Tau Toxicity Modifiers in the Drosophila Eye by Dourlen, Pierre

“…Drosophila is a powerful model to study human diseases thanks to its genetic tools and ease of screening. Human genes can be expressed in targeted organs and…”
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Pin1 allows for differential Tau dephosphorylation in neuronal cells by Hamdane, Malika, Dourlen, Pierre, Bretteville, Alexis, Sambo, Anne-Véronique, Ferreira, Stéphanie, Ando, Kunie, Kerdraon, Olivier, Bégard, Séverine, Geay, Linda, Lippens, Guy, Sergeant, Nicolas, Delacourte, André, Maurage, Claude-Alain, Galas, Marie-Christine, Buée, Luc

“…Neurofibrillary degeneration is likely to be related to abnormal Tau phosphorylation and aggregation. Among abnormal Tau phosphorylation sites, pThr231 is of…”
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The Peptidylprolyl cis/trans-Isomerase Pin1 Modulates Stress-induced Dephosphorylation of Tau in Neurons by Galas, Marie-Christine, Dourlen, Pierre, Bégard, Séverine, Ando, Kunié, Blum, David, Hamdane, Malika, Buée, Luc

“…Deregulation of Tau phosphorylation is a key question in Alzheimer disease pathogenesis. Recently, Pin1, a peptidylprolyl cis/trans-isomerase, was proposed to…”
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In vivo assessment of neuronal cell death in Drosophila by Dourlen, Pierre

“…Following neuronal cell death at the cellular level and over several time points is challenging in living animal because of the difficulty of accessing and…”
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Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals by Dourlen, Pierre, Chapuis, Julien, Lambert, Jean-Charles

“…Purpose of Review The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of…”
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ER stress protects from retinal degeneration by Mendes, César S, Levet, Clémence, Chatelain, Gilles, Dourlen, Pierre, Fouillet, Antoine, Dichtel-Danjoy, Marie-Laure, Gambis, Alexis, Ryoo, Hyung Don, Steller, Hermann, Mollereau, Bertrand

“…The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the…”
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Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism by Chapuis, Julien, Flaig, Amandine, Grenier-Boley, Benjamin, Eysert, Fanny, Pottiez, Virginie, Deloison, Gaspard, Vandeputte, Alexandre, Ayral, Anne-Marie, Mendes, Tiago, Desai, Shruti, Goate, Alison M., Kauwe, John S. K., Leroux, Florence, Herledan, Adrien, Demiautte, Florie, Bauer, Charlotte, Checler, Fréderic, Petersen, Ronald C., Blennow, Kaj, Zetterberg, Henrik, Minthon, Lennart, Van Deerlin, Vivianna M., Lee, Virginia Man-Yee, Shaw, Leslie M., Trojanowski, John Q., Albert, Marilyn, Moghekar, Abhay, O’Brien, Richard, Peskind, Elaine R., Malmanche, Nicolas, Schellenberg, Gerard D., Dourlen, Pierre, Song, Ok-Ryul, Cruchaga, Carlos, Amouyel, Philippe, Deprez, Benoit, Brodin, Priscille, Lambert, Jean-Charles

“…Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer’s disease (AD). However, understanding how these genes are…”
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Isoform‐dependent neurotoxicity of the Alzheimer disease risk factor BIN1: Molecular and cell biology/endosomal‐lysosomal dysfunction by Lambert, Erwan, Abdelfettah, Farida, Barois, Nicolas, Vandekerkhove, Dirk, Hermant, Xavier, Ayral, Anne‐Marie, Davoine, Lindsay, Dupont, Cloe, Lafont, Frank, Amouyel, Philippe, Chapuis, Julien, Verstreken, Patrik, Dermaut, Bart, Lambert, Jean‐Charles, Dourlen, Pierre

“…Abstract Background Using genome‐wide association studies, BIN1 was identified as the most associated risk gene for Alzheimer’s Disease (AD) after APOE . A 3bp…”
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Isoform‐dependent neurotoxicity of the Alzheimer disease risk factor BIN1 by Lambert, Erwan, Abdelfettah, Farida, Barois, Nicolas, Vandekerkhove, Dirk, Hermant, Xavier, Ayral, Anne‐Marie, Davoine, Lindsay, Dupont, Cloe, Lafont, Frank, Amouyel, Philippe, Chapuis, Julien, Verstreken, Patrik, Dermaut, Bart, Lambert, Jean‐Charles, Dourlen, Pierre

“…Background Using genome‐wide association studies, BIN1 was identified as the most associated risk gene for Alzheimer’s Disease (AD) after APOE. A 3bp insertion…”
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Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease by Gusareva, Elena S., Twizere, Jean-Claude, Sleegers, Kristel, Dourlen, Pierre, Abisambra, Jose F., Meier, Shelby, Cloyd, Ryan, Weiss, Blaine, Dermaut, Bart, Bessonov, Kyrylo, van der Lee, Sven J., Carrasquillo, Minerva M., Katsumata, Yuriko, Cherkaoui, Majid, Asselbergh, Bob, Ikram, M. Arfan, Mayeux, Richard, Farrer, Lindsay A., Haines, Jonathan L., Pericak-Vance, Margaret A., Schellenberg, Gerard D., Sims, Rebecca, Williams, Julie, Amouyel, Philippe, van Duijn, Cornelia M., Ertekin-Taner, Nilüfer, Van Broeckhoven, Christine, Dequiedt, Franck, Fardo, David W., Lambert, Jean-Charles, Van Steen, Kristel

“…Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a…”
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