Search Results - "Dourlen, P"

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology by Dourlen, P, Fernandez-Gomez, F J, Dupont, C, Grenier-Boley, B, Bellenguez, C, Obriot, H, Caillierez, R, Sottejeau, Y, Chapuis, J, Bretteville, A, Abdelfettah, F, Delay, C, Malmanche, N, Soininen, H, Hiltunen, M, Galas, M-C, Amouyel, P, Sergeant, N, Buée, L, Lambert, J-C, Dermaut, B

“…A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE ) in which the functional genes are…”
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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology by Chapuis, J, Hansmannel, F, Gistelinck, M, Mounier, A, Van Cauwenberghe, C, Kolen, K V, Geller, F, Sottejeau, Y, Harold, D, Dourlen, P, Grenier-Boley, B, Kamatani, Y, Delepine, B, Demiautte, F, Zelenika, D, Zommer, N, Hamdane, M, Bellenguez, C, Dartigues, J-F, Hauw, J-J, Letronne, F, Ayral, A-M, Sleegers, K, Schellens, A, Broeck, L V, Engelborghs, S, De Deyn, P P, Vandenberghe, R, O'Donovan, M, Owen, M, Epelbaum, J, Mercken, M, Karran, E, Bantscheff, M, Drewes, G, Joberty, G, Campion, D, Octave, J-N, Berr, C, Lathrop, M, Callaerts, P, Mann, D, Williams, J, Buée, L, Dewachter, I, Van Broeckhoven, C, Amouyel, P, Moechars, D, Dermaut, B, Lambert, J-C

“…Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer’s…”
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Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation by Dichtel-Danjoy, M-L, Ma, D, Dourlen, P, Chatelain, G, Napoletano, F, Robin, M, Corbet, M, Levet, C, Hafsi, H, Hainaut, P, Ryoo, H D, Bourdon, J-C, Mollereau, B

“…Irradiated or injured cells enter apoptosis, and in turn, promote proliferation of surrounding unaffected cells. In Drosophila , apoptotic cells have an active…”
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The peptidyl prolyl cis/trans isomerase Pin1 downregulates the Inhibitor of Apoptosis Protein Survivin by Dourlen, P., Ando, K., Hamdane, M., Begard, S., Buée, L., Galas, M.C.

“…The peptidyl prolyl cis–trans isomerase Pin1 and the Inhibitor of Apoptosis Protein (IAP) Survivin are two major proteins involved in cancer. They both…”
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Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina by Van Den Brink, Daan M, Cubizolle, Aurélie, Chatelain, Gilles, Davoust, Nathalie, Girard, Victor, Johansen, Simone, Napoletano, Francesco, Dourlen, Pierre, Guillou, Laurent, Angebault-Prouteau, Claire, Bernoud-Hubac, Nathalie, Guichardant, Michel, Brabet, Philippe, Mollereau, Bertrand

“…Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular…”
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Pin1 allows for differential Tau dephosphorylation in neuronal cells by Hamdane, Malika, Dourlen, Pierre, Bretteville, Alexis, Sambo, Anne-Véronique, Ferreira, Stéphanie, Ando, Kunie, Kerdraon, Olivier, Bégard, Séverine, Geay, Linda, Lippens, Guy, Sergeant, Nicolas, Delacourte, André, Maurage, Claude-Alain, Galas, Marie-Christine, Buée, Luc

“…Neurofibrillary degeneration is likely to be related to abnormal Tau phosphorylation and aggregation. Among abnormal Tau phosphorylation sites, pThr231 is of…”
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P1-10 The prolyl isomerase PIN1 modulates oxydative stress-induced dephosphorylation of tau in neurons by Galas, M.C., Dourlen, P., Bégard, S., Vandesquille, M., Hamdame, M., Buée, L.

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C2-4 La protéine microtubulaire Tau : le ying et le yang des tauopathies by Hamdane, M., Bretteville, A., Ando, K., Dourlen, P., Schindowski, K., Kerdraon, O., Bégard, S., Schraen-Mashke, S., Caillet-Boudin, M.L., Sergeant, N., Delacourte, A., Galas, M.C., Maurage, C.A., Buée, L.

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