Search Results - "Dounane, Omar"

Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress by Chambraud, Béatrice, Daguinot, Corentin, Guillemeau, Kevin, Genet, Melanie, Dounane, Omar, Meduri, Geri, Poüs, Christian, Baulieu, Etienne Emile, Giustiniani, Julien

“…Defects of autophagy-lysosomal protein degradation are thought to contribute to the pathogenesis of several neurodegenerative diseases, and the accumulation of…”
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role for FKBP52 in Tau protein function by Chambraud, Béatrice, Sardin, Elodie, Giustiniani, Julien, Dounane, Omar, Schumacher, Michael, Goedert, Michel, Baulieu, Etienne-Emile

“…Tau is a microtubule-associated protein, which is widely expressed in the central nervous system, predominantly in neurons, where it regulates microtubule…”
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Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy by Giustiniani, Julien, Chambraud, Béatrice, Sardin, Elodie, Dounane, Omar, Guillemeau, Kevin, Nakatani, Hiroko, Paquet, Dominik, Kamah, Amina, Landrieu, Isabelle, Lippens, Guy, Baulieu, Etienne-Emile, Tawk, Marcel

“…The Tau protein is the major component of intracellular filaments observed in a number of neurodegenerative diseases known as tauopathies. The pathological…”
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Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies by Meduri, Geri, Guillemeau, Kevin, Daguinot, Corentin, Dounane, Omar, Genet, Melanie, Ferrara, Luigi, Chambraud, Beatrice, Baulieu, Etienne Emile, Giustiniani, Julien

“…Pathological tau proteins constitute neurofibrillary tangles that accumulate in tauopathies including Alzheimer's disease (AD), progressive supranuclear palsy…”
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Caspase-cleaved Tau-D(421) is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons by Meduri, Geri, Guillemeau, Kevin, Dounane, Omar, Sazdovitch, Véronique, Duyckaerts, Charles, Chambraud, Béatrice, Baulieu, Etienne Emile, Giustiniani, Julien

“…Pathologic modifications of the Tau protein leading to neurofibrillary tangle (NFT) formation are a common feature of a wide range of neurodegenerative…”
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The FK506‐binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion‐like behavior by Giustiniani, Julien, Guillemeau, Kevin, Dounane, Omar, Sardin, Elodie, Huvent, Isabelle, Schmitt, Alain, Hamdane, Malika, Buée, Luc, Landrieu, Isabelle, Lippens, Guy, Baulieu, Etienne Emile, Chambraud, Béatrice

“…Tauopathies, including Alzheimer's disease (AD), are neurodegenerative diseases associated with the pathologic aggregation of human brain Tau protein. Neuronal…”
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Caspase-cleaved Tau-D421 is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons by Meduri, Geri, Guillemeau, Kevin, Dounane, Omar, Sazdovitch, Véronique, Duyckaerts, Charles, Chambraud, Béatrice, Baulieu, Etienne Emile, Giustiniani, Julien

“…Pathologic modifications of the Tau protein leading to neurofibrillary tangle (NFT) formation are a common feature of a wide range of neurodegenerative…”
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Caspase-cleaved Tau-D421 iscolocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer’s disease neurons by Meduri, Geri, Guillemeau, Kevin, Dounane, Omar, Sazdovitch, Véronique, Duyckaerts, Charles, Chambraud, Béatrice, Baulieu, Etienne Emile, Giustiniani, Julien

“…Abstract Pathological modifications of the Tau protein leading to neurofibrillary tangle (NFT) formation are a common feature of a wide range of…”
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Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17 by Giustiniani, Julien, Sineus, Marlène, Sardin, Elodie, Dounane, Omar, Panchal, Maï, Sazdovitch, Véronique, Duyckaerts, Charles, Chambraud, Béatrice, Baulieu, Etienne-Emile

“…Human neurodegenerative diseases characterized by abnormal intraneuronal inclusions of the tau protein, or "tauopathies", include Alzheimer's disease (AD),…”
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