Search Results - "Douglas R. Drummond"

Anchoring geometry is a significant factor in determining the direction of kinesin-14 motility on microtubules by Yamagishi, Masahiko, Sumiyoshi, Rieko, Drummond, Douglas R., Yajima, Junichiro

“…Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to its load and usually move towards microtubule minus ends, whilst…”
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Regulation of microtubule dynamics by kinesins by Drummond, Douglas R.

“…The simple mechanistic and functional division of the kinesin family into either active translocators or non-motile microtubule depolymerases was initially…”
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S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules by Erent, Muriel, Drummond, Douglas R, Cross, Robert A

“…The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here…”
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Ectopic A-lattice seams destabilize microtubules by Katsuki, Miho, Drummond, Douglas R., Cross, Robert A.

“…Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams…”
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Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism by Hussmann, Frauke, Drummond, Douglas R., Peet, Daniel R., Martin, Douglas S., Cross, Robert A.

“…Alp14 is a TOG-family microtubule polymerase from S. pombe that tracks plus ends and accelerates their growth. To interrogate its mechanism, we reconstituted…”
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ATP Gate Controls Tubulin Binding by the Tethered Head of Kinesin-1 by Alonso, Maria C, Drummond, Douglas R, Kain, Susan, Hoeng, Julia, Amos, Linda, Cross, Robert A

“…Kinesin-1 is a two-headed molecular motor that walks along microtubules, with each step gated by adenosine triphosphate (ATP) binding. Existing models for the…”
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Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice by des Georges, Amédée, Cross, Robert A, Amos, Linda A, Katsuki, Miho, Drummond, Douglas R, Osei, Michael

“…In vitro , pure tubulin assembles into B-lattice microtubules, in which lateral αα and ββ contacts between tubulin heterodimers predominate. Mal3, a homolog of…”
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Mal3 Masks Catastrophe Events in Schizosaccharomyces pombe Microtubules by Inhibiting Shrinkage and Promoting Rescue by Katsuki, Miho, Drummond, Douglas R., Osei, Michael, Cross, Robert A.

“…Schizosaccharomyces pombe Mal3 is a member of the EB family of proteins, which are proposed to be core elements in a tip-tracking network that regulates…”
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Purification of tubulin from the fission yeast Schizosaccharomyces pombe by Drummond, Douglas R, Kain, Susan, Newcombe, Anthony, Hoey, Christina, Katsuki, Miho, Cross, Robert A

“…The fission yeast Schizosaccharomyces pombe is an attractive source of tubulin for biochemical experiments as it contains few tubulin isoforms and is amenable…”
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The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism by Braun, Marcus, McAinsh, Andrew D, Cross, Robert A, Drummond, Douglas R

“…The dynamic organization of microtubules into parallel arrays allows interphase cells to set up multi-lane highways for intracellular transport and M-phase…”
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Dynamics of interphase microtubules in Schizosaccharomyces pombe by Drummond, Douglas R., Cross, Robert A.

“…Background: Microtubules in interphase Schizosaccharomyces pombe are essential for maintaining the linear growth habit of these cells. The dynamics of assembly…”
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Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins by Drummond, D.R, Hagan, I.M

“…Members of the bimC family of kinesin related proteins (KRPs) play vital roles in the formation and function of the mitotic spindle. Although they share little…”
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Dynamics of A-Lattice Microtubules by Katsuki, Miho, Drummond, Douglas R., Cross, Robert A.

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Alteration in crossbridge kinetics caused by mutations in actin by Drummond, D.R, Peckham, M, Sparrow, J.C, White, D.C.S

“…The generation of force during muscle contraction results from the interaction of myosin and actin. The kinetics of this force generation vary between…”
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Microtubule Dynamics of S. Pombe Tubulin by Drummond, Douglas R., Hoey, Christina, Stein, Merle, Kaya-Copur, Aynur, Kain, Susan, Osei, Michael, Cross, Robert A.

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The effect of capping and polyadenylation on the stability, movement and translation of synthetic messenger RNAs in Xenopus oocytes by Drummond, Douglas R., Armstrong, John, Colman, Alan

“…Synthetic RNAs coding for chicken lysozyme, calf preprochymozin and Xenopus globin were transcribed in vitro using Sp6 RNA polymerase. The effects of capping…”
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Contribution of the Transforming Growth Factor α B-loop β-Sheet to Binding and Activation of the Epidermal Growth Factor Receptor (∗) by Richter, Audrey, Drummond, Douglas R., MacGarvie, Jennie, Puddicombe, Sarah M., Chamberlin, Stephen G., Davies, Donna E.

“…We have exploited the differences in binding affinities of the chicken epidermal growth factor (EGF) receptor for EGF and transforming growth factor α (TGFα)…”
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The Significance of Valine 33 as a Ligand-specific Epitope of Transforming Growth Factor Î by Sarah M. Puddicombe, Stephen G. Chamberlin, Jennie MacGarvie, Audrey Richter, Douglas R. Drummond, Jane Collins, Lynn Wood, Donna E. Davies

“…Although binding of epidermal growth factor (EGF) and transforming growth factor α (TGFα) to the EGF receptor (EGFR) is mutually competitive, their binding…”
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Contribution of the Transforming Growth Factor B-loop -Sheet to Binding and Activation of the Epidermal Growth Factor Receptor by Audrey Richter, Douglas R. Drummond, Jennie MacGarvie, Sarah M. Puddicombe, Stephen G. Chamberlin, Donna E. Davies

“…We have exploited the differences in binding affinities of the chicken epidermal growth factor (EGF) receptor for EGF and transforming growth factor α (TGFα)…”
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The significance of valine 33 as a ligand-specific epitope of transforming growth factor alpha by Puddicombe, S M, Chamberlin, S G, MacGarvie, J, Richter, A, Drummond, D R, Collins, J, Wood, L, Davies, D E

“…Although binding of epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha) to the EGF receptor (EGFR) is mutually competitive, their…”
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