Search Results - "Douglas Macmillan, R"

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer by MAHMOUD, Sahar M. A, CLAIRE PAISH, Emma, POWE, Desmond G, MACMILLAN, R. Douglas, GRAINGE, Matthew J, LEE, Andrew H. S, ELLIS, Ian O, GREEN, Andrew R

“…Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains unclear…”
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Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery by Shipp, Dustin W, Rakha, Emad A, Koloydenko, Alexey A, Macmillan, R Douglas, Ellis, Ian O, Notingher, Ioan

“…In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional…”
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Comparing Oncoplastic Breast Conserving Surgery with Mastectomy and Immediate Breast Reconstruction: Case-Matched Patient Reported Outcomes by Kelsall, Jennett E., B. Med Sci, MBBS, FRACS, McCulley, Stephen J., MBChB, FCS (SA) (Plast), FRCS (Plast), Brock, Lisa, BSc (Hons) (Sociology), Akerlund, Malin T.E., BSc (Psychology), Macmillan, R. Douglas, MBChB, MD, FRCS

“…Summary Background Oncoplastic breast conserving surgery (OBCS) allows women who may otherwise have mastectomy and immediate reconstruction (MxIR) the choice…”
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Multicenter Evaluation of Hydrodissection-Assisted Mastectomy (HAM) by Asgeirsson, Kristjan S., Dixon, J. Michael, Darrigues, Lauren, Sarfati, Benjamin, Macmillan, R. Douglas

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Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen by Habashy, Hany Onsy, Powe, Desmond G, Staka, Cindy M, Rakha, Emad A, Ball, Graham, Green, Andrew R, Aleskandarany, Mohammed, Paish, E. Claire, Douglas Macmillan, R, Nicholson, Robert I, Ellis, Ian O, Gee, Julia M. W

“…Transferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation. It may be implicated in promoting the…”
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An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer by Mahmoud, Sahar M. A., Paish, Emma C., Powe, Desmond G., Macmillan, R. Douglas, Lee, Andrew H. S., Ellis, Ian O., Green, Andrew R.

“…Studies in mice have shown that thymic-derived CD4+ CD25+ regulatory T cells (T reg; FOXP3 + lymphocytes) inhibit an antitumour immune response. Additional…”
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The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ by Miligy, Islam M., Toss, Michael S., Shiino, Sho, Oni, Georgette, Syed, Binafsha M., Khout, Hazem, Tan, Qing Ting, Green, Andrew R., Macmillan, R. Douglas, Robertson, John F. R., Rakha, Emad A.

“…Background Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we…”
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Correction: The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ by Miligy, Islam M., Toss, Michael S., Shiino, Sho, Oni, Georgette, Syed, Binafsha M., Khout, Hazem, Tan, Qing Ting, Green, Andrew R., Macmillan, R. Douglas, Robertson, John F. R., Rakha, Emad A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Correction: The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ by Miligy, Islam M., Toss, Michael S., Shiino, Sho, Oni, Georgette, Syed, Binafsha M., Khout, Hazem, Tan, Qing Ting, Green, Andrew R., Macmillan, R. Douglas, Robertson, John F. R., Rakha, Emad A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast by Fernández, Beatriz, Paish, E Claire, Green, Andrew R, Lee, Andrew H S, Macmillan, R Douglas, Ellis, Ian O, Rakha, Emad A

“…Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast are distinct morphological entities with different biological features and…”
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EpCAM expression is an indicator of recurrence in basal-like breast cancer by Agboola, Ayodeji J., Paish, E. Claire, Rakha, Emad A., Powe, Desmond G., Macmillan, R. Douglas, Ellis, Ian O., Green, Andrew R.

“…Advances in the understanding of the molecular basis of breast cancer have necessitated a definition of more sensitive and specific indicators of prognosis…”
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A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients by Soria, Daniele, Garibaldi, Jonathan M, Ambrogi, Federico, Green, Andrew R, Powe, Des, Rakha, Emad, Douglas Macmillan, R, Blamey, Roger W, Ball, Graham, Lisboa, Paulo J.G, Etchells, Terence A, Boracchi, Patrizia, Biganzoli, Elia, Ellis, Ian O

“…Abstract Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is…”
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Explantation with Lateral Pedicle Mastopexy by Macmillan, R Douglas, Bell, Kara, Wilson, Emma, Asgeirsson, Kristjan S

“…While breast explantation combined with mastopexy is an increasingly common procedure, it does present certain technical difficulties. We present a technique…”
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The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients by Khoshnaw, Sarkawt M., Rakha, Emad A., Abdel-Fatah, Tarek, Nolan, Christopher C., Hodi, Zsolt, Macmillan, R. Douglas, Ellis, Ian O., Green, Andrew R.

“…Drosha is a protein that plays a key role in the biogenesis of microRNAs which are well known to be deranged in human breast cancer (BC). The purpose of the…”
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Growth fraction as a predictor of response to chemotherapy in node‐negative breast cancer by Aleskandarany, Mohammed A., Green, Andrew R., Rakha, Emad A., Mohammed, Rabab A., Elsheikh, Somaia E., Powe, Desmond G., Paish, Emma C., Macmillan, R. Douglas, Chan, Steve, Ahmed, Samreen I., Ellis, Ian O.

“…Accurate predictive markers of chemotherapeutic response in early breast cancer are still lacking. The role of tumour growth fraction as a predictor of…”
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The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome by Green, Andrew R., Burney, Claire, Granger, Christopher J., Paish, E. Claire, El-Sheikh, Somaia, Rakha, Emad A., Powe, Desmond G., Macmillan, R. Douglas, Ellis, Ian O., Stylianou, Eleni

“…Background Advances in understanding the molecular basis of breast cancer has necessitated a definition of improved indicators of prognosis that are central to…”
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The TeaM ( T h e r a peutic M ammaplasty) study: Protocol for a prospective multi-centre cohort study to evaluate the practice and outcomes of therapeutic mammaplasty by Baker, Elizabeth, Kim, Baek, Rattay, Tim, Williams, Kathryn, Ives, Charlotte, Remoundos, Dennis, Holcombe, Chris, Gardiner, Matthew D, Jain, Abhilash, Sutton, Richard, Achuthan, Rajgopal, Turton, Philip, Fairbrother, Patricia, Brock, Lisa, Aggarwal, Shweta, Basu, Naren, Murphy, John, Trickey, Adam, Macmillan, R. Douglas, Potter, Shelley

“…Highlights • Multicentre prospective study involving breast and plastic surgical units across the UK. • Will produce valuable data regarding the practice and…”
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A Case-Controlled Study of the Oncologic Safety of Fat Grafting by Gale, Katherine L., Rakha, Emad A., Ball, Graham, Tan, Veronique K., McCulley, Stephen J., Macmillan, R. Douglas

“…Currently, there is no clinical evidence of oncologic risk associated with fat grafting, although its safety has been questioned. The authors investigated the…”
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Is immediate autologous breast reconstruction with postoperative radiotherapy good practice?: A systematic review of the literature by Schaverien, Mark V, Macmillan, R. Douglas, McCulley, Stephen J

“…Summary Background There remains controversy as to whether immediate autologous breast reconstruction with postoperative radiotherapy is associated with…”
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MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours by Green, Andrew R, Aleskandarany, Mohammed A, Agarwal, Devika, Elsheikh, Somaia, Nolan, Christopher C, Diez-Rodriguez, Maria, Macmillan, R Douglas, Ball, Graham R, Caldas, Carlos, Madhusudan, Srinivasan, Ellis, Ian O, Rakha, Emad A

“…Background: MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates…”
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