Search Results - "Douglas H. Ohlendorf"

Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms by Huseby, Medora J., Kruse, Andrew C., Digre, Jeff, Kohler, Petra L., Vocke, Jillian A., Mann, Ethan E., Bayles, Kenneth W., Bohach, Gregory A., Schlievert, Patrick M., Ohlendorf, Douglas H., Earhart, Cathleen A., Novick, Richard P.

“…Biofilms are surface-associated communities of microbes encompassed by an extracellular matrix. It is estimated that 80% of all bacterial infections involve…”
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Structure and Biological Activities of Beta Toxin from Staphylococcus aureus by HUSEBY, Medora, SHI, Ke, BROWN, C. Kent, DIGRE, Jeff, MENGISTU, Fikre, KEUN SEOK SEO, BOHACH, Gregory A, SCHLIEVERT, Patrick M, OHLENDORF, Douglas H, EARHART, Cathleen A

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Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins by Hertzel, Ann V, Hellberg, Kristina, Reynolds, Joseph M, Kruse, Andrew C, Juhlmann, Brittany E, Smith, Anne J, Sanders, Mark A, Ohlendorf, Douglas H, Suttles, Jill, Bernlohr, David A

“…Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. Because small molecule…”
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STructure of Peptide Sex Pheromone Receptor PrgX and PrgX/Pheromone Complexes and Regulation of Conjugation in Enterococcus faecalis by Ke Shi, Brown, C. Kent, Zu-Yi Gu, Briana K. Kozlowicz, Dunny, Gary M., Douglas H. Ohlendorf, Cathleen A. Earhart, Greenberg, E. Peter

“…Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by…”
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Crystallographic Comparison of Manganese- and Iron-Dependent Homoprotocatechuate 2,3-Dioxygenases by VETTING, Matthew W, WACKETT, Lawrence P, QUE, Lawrence JR, LIPSCOMB, John D, OHLENDORF, Douglas H

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The 1.8 Å crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker by Vetting, Matthew W, Ohlendorf, Douglas H

“…Background: Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates…”
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Characterization of a Novel Staphylococcal Enterotoxin-like Superantigen, a Member of the Group V Subfamily of Pyrogenic Toxins by Orwin, Paul M, Leung, Donald Y. M, Tripp, Timothy J, Bohach, Gregory A, Earhart, Cathleen A, Ohlendorf, Douglas H, Schlievert, Patrick M

“…Staphylococcus aureus is an important human pathogen, causing a variety of diseases. Major virulence factors of this organism include staphylococcal…”
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Structure of the Streptococcal Cell Wall C5a Peptidase by Brown, C. Kent, Zu-Yi Gu, Yury V. Matsuka, Sai S. Purushothaman, Laurie A. Winter, Cleary, P. Patrick, Stephen B. Olmsted, Douglas H. Ohlendorf, Cathleen A. Earhart, Matthews, Brian W.

“…The structure of a cell surface enzyme from a Gram-positive pathogen has been determined to 2-Å resolution. Gram-positive pathogens have a thick cell wall to…”
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Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla by Earhart, Cathleen A., Vetting, Matthew W., Gosu, Ramachandraiah, Michaud-Soret, Isabelle, Que, Lawrence, Ohlendorf, Douglas H.

“…Catechol 1,2-dioxygenase was first studied by Hayaishi and colleagues in 1950. In 1967, catechol 1,2-dioxygenase from Pseudomonas arvilla C-1 (PaCTD) was…”
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Crystal Structures of Substrate and Substrate Analog Complexes of Protocatechuate 3,4-Dioxygenase:  Endogenous Fe3+ Ligand Displacement in Response to Substrate Binding by Orville, Allen M, Lipscomb, John D, Ohlendorf, Douglas H

“…Protocatechuate 3,4-dioxygenase (3,4-PCD) utilizes a ferric ion to catalyze the aromatic ring cleavage of 3,4-dihydroxybenzoate (PCA) by incorporation of both…”
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Structure of Acinetobacter Strain ADP1 Protocatechuate 3,4-Dioxygenase at 2.2 Å Resolution:  Implications for the Mechanism of an Intradiol Dioxygenase by Vetting, Matthew W, D'Argenio, David A, Ornston, L. Nicholas, Ohlendorf, Douglas H

“…The crystal structures of protocatechuate 3,4-dioxygenase from the soil bacteria Acinetobacter strain ADP1 (Ac 3,4-PCD) have been determined in space group I23…”
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Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab −/− mice by Yoder, Andrea R., Kruse, Andrew C., Earhart, Cathleen A., Ohlendorf, Douglas H., Potter, Lincoln R.

“…C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B…”
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Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks by SMOOT, Laura M, MCCORMICK, John K, HILL, Harry R, LEUNG, Donald Y. M, SCHLIEVERT, Patrick M, MUSSER, James M, SMOOT, James C, HOE, Nancy P, STRICKLAND, Ian, COLE, Robert L, BARBIAN, Kent D, EARHART, Cathleen A, OHLENDORF, Douglas H, VEASY, L. George

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The Structure of the Superantigen Exfoliative Toxin A Suggests a Novel Regulation as a Serine Protease by Vath, Gregory M, Earhart, Cathleen A, Rago, James V, Kim, Michael H, Bohach, Gregory A, Schlievert, Patrick M, Ohlendorf, Douglas H

“…Exfoliative toxin A (ETA) causes staphylococcal scalded skin syndrome which is characterized by a specific intraepidermal separation of layers of the skin. The…”
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Structures of Competitive Inhibitor Complexes of Protocatechuate 3,4-Dioxygenase:  Multiple Exogenous Ligand Binding Orientations within the Active Site by Orville, Allen M, Elango, Natesan, Lipscomb, John D, Ohlendorf, Douglas H

“…Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce β-carboxy-cis,cis-muconate. Crystal…”
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Structural evidence for the evolution of pyrogenic toxin superantigens by Mitchell, D T, Levitt, D G, Schlievert, P M, Ohlendorf, D H

“…Pathogenic bacteria have evolved a wide variety of toxins to invade and attack host organisms. In particular, strains of the bacteria Staphylococcus aureus and…”
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X‐ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4‐hydroxy‐2‐nonenal by Hellberg, Kristina, Grimsrud, Paul A., Kruse, Andrew C., Banaszak, Leonard J., Ohlendorf, Douglas H., Bernlohr, David A.

“…Fatty acid binding proteins (FABP) have been characterized as facilitating the intracellular solubilization and transport of long‐chain fatty acyl carboxylates…”
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Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides by Kozlowicz, Briana K., Shi, Ke, Gu, Zu‐Yi, Ohlendorf, Douglas H., Earhart, Cathleen A., Dunny, Gary M.

“…Summary In many bacteria expression of lateral gene transfer and of virulence factors is controlled by cell–cell signalling systems. Molecular interactions of…”
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Substitution, Insertion, Deletion, Suppression, and Altered Substrate Specificity in Functional Protocatechuate 3,4-Dioxygenases by D'Argenio, D A, Vetting, M W, Ohlendorf, D H, Ornston, L N

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Roles of the Equatorial Tyrosyl Iron Ligand of Protocatechuate 3,4-Dioxygenase in Catalysis by Valley, Michael P, Brown, C. Kent, Burk, David L, Vetting, Matthew W, Ohlendorf, Douglas H, Lipscomb, John D

“…The active site Fe(III) of protocatechuate 3,4-dioxygenase (3,4-PCD) from Pseudomonas putida is ligated axially by Tyr447 and His462 and equatorially by…”
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