Search Results - "Douglas, Steven D."

Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation by Douglas, Steven D., Leeman, Susan E.

“…The G protein–coupled receptor (GPCR), neurokinin‐1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune…”
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Neurokinin 1 Receptor Mediates Membrane Blebbing in HEK293 Cells through a Rho/Rho-associated Coiled-coil Kinase-dependent Mechanism by Meshki, John, Douglas, Steven D., Lai, Jian-Ping, Schwartz, Lynnae, Kilpatrick, Laurie E., Tuluc, Florin

“…We have investigated the effect of neurokinin 1 receptor (NK1R) agonists on HEK293 cells transfected with the NK1R receptor. The NK1R receptor mediates…”
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Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner by Meshki, John, Douglas, Steven D, Hu, Mingyue, Leeman, Susan E, Tuluc, Florin

“…U373MG astrocytoma cells endogenously express the full-length neurokinin 1 receptor (NK1R). Substance P (SP), the natural ligand for NK1R, triggers rapid and…”
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Neurokinin 1 receptor isoforms and the control of innate immunity by Tuluc, Florin, Lai, Jian Ping, Kilpatrick, Laurie E, Evans, Dwight L, Douglas, Steven D

“…Substance P is the prototype tachykinin peptide and triggers a variety of biological effects in both the nervous and immune system. Two naturally occurring…”
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Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor by Lai, Jian-Ping, Lai, Saien, Tuluc, Florin, Tansky, Morris F, Kilpatrick, Laurie E, Leeman, Susan E, Douglas, Steven D

“…The neurokinin-1 receptor (NK1R) has two naturally occurring forms that differ in the length of the carboxyl terminus: a full-length receptor consisting of 407…”
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Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV by Barrett, Jeffrey S, Spitsin, Sergei, Moorthy, Ganesh, Barrett, Kyle, Baker, Kate, Lackner, Andrew, Tulic, Florin, Winters, Angela, Evans, Dwight L, Douglas, Steven D

“…Many HIV infected individuals with suppressed viral loads experience chronic immune activation frequently developing neurological impairment designated as HIV…”
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Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells by Chen, Panpan, Douglas, Steven D, Meshki, John, Tuluc, Florin

“…Cell-derived microparticles participate in intercellular communication similar to the classical messenger systems of small and macro-molecules that bind to…”
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Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R) by Chernova, Irene, Lai, Jian‐Ping, Li, Haiying, Schwartz, Lynnae, Tuluc, Florin, Korchak, Helen M., Douglas, Steven D., Kilpatrick, Laurie E.

“…Substance P (SP) is a potent modulator of monocyte/macrophage function. The SP‐preferring receptor neurokinin‐1 receptor (NK1R) has two forms: a full‐length…”
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Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor by Monaco‐Shawver, Linda, Schwartz, Lynnae, Tuluc, Florin, Guo, Chang‐Jiang, Lai, Jian Ping, Gunnam, Satya M., Kilpatrick, Laurie E., Banerjee, Pinaki P., Douglas, Steven D., Orange, Jordan S.

“…Ligation of neurokinin 1 receptor by substance P in NK cells can reduce calcium flux and cytotoxicity through interference with activation‐induced ERK…”
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Truncation of neurokinin‐1 receptor—Negative regulation of substance P signaling by Spitsin, Sergei, Pappa, Vasiliki, Douglas, Steven D.

“…Substance P (SP) is a tachykinin peptide, which triggers intracellular signaling in the nervous and immune systems, as well as, other local and systemic…”
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Protection against SIV in Rhesus Macaques Using Albumin and CD4-Based Vector-Mediated Gene Transfer by Spitsin, Sergei, Schnepp, Bruce C., Connell, Mary J., Liu, Tehui, Dang, Christine M., Pappa, Vasiliki, Tustin, Richard, Kinder, Annemarie, Johnson, Philip R., Douglas, Steven D.

“…Antibody-like molecules were evaluated with potent simian immunodeficiency virus (SIV) neutralizing properties (immunoadhesins) that were delivered by a…”
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A randomized, placebo controlled, double masked phase IB study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults by Tebas, Pablo, Tuluc, Florin, Barrett, Jeffrey S, Wagner, Wayne, Kim, Deborah, Zhao, Huaquing, Gonin, René, Korelitz, James, Douglas, Steven D

“…Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expression and improve natural killer cell…”
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Immune suppression and immune activation in depression by Blume, Joshua, Douglas, Steven D, Evans, Dwight L

“…Research highlights ► Depression is associated with immune suppression and immune activation. ► How immune suppression and activation relate to each other in…”
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Substance P and sickle cell disease—a marker for pain and novel therapeutic approaches by Douglas, Steven D.

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Natural killer cells inhibit hepatitis C virus expression by Li, Yuan, Zhang, Ting, Ho, Chun, Orange, Jordan S., Douglas, Steven D., Ho, Wen‐Zhe

“…Natural killer (NK) cells are critical in host innate defense against certain viruses. The role of NK cells in controlling hepatitis C virus (HCV) remains…”
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Detection of full-length and truncated neurokinin-1 receptor mRNA expression in human brain regions by Lai, Jian-Ping, Cnaan, Avital, Zhao, Huaqing, Douglas, Steven D.

“…We have applied a newly developed SYBR green-based real-time RT-PCR assay for quantification of full-length and truncated neurokinin-1 receptor (NK1R) mRNA…”
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Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes by Pappa, Vasiliki, Spitsin, Sergei, Gaskill, Peter J., Douglas, Steven D.

“…Neurokinin-1 receptor (NK1R) signaling can be immunomodulatory and it can lead to preferential transmigration of CD14+CD16+ monocytes across the blood brain…”
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Programmed Death 1 Receptor Changes Ex Vivo in HIV-Infected Adults following Initiation of Highly Active Antiretroviral Therapy by Spitsin, Sergei, Tustin, Nancy B, Riedel, Eric, Tustin, 3rd, Richard, Murray, Jennifer B, Peck, Lauren M, Khan, Mohammad, Quinn, Joseph, Douglas, Steven D

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV by Spitsin, Sergei, Pappa, Vasiliki, Kinder, Annemarie, Evans, Dwight L., Rappaport, Jay, Douglas, Steven D.

“…Changes in tryptophan metabolism affect human physiology including the immune system, mood, and sleep and are associated with human immunodeficiency virus…”
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Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor by Douglas, Steven D., Spitsin, Sergei

“…Discussion on the potential role for CXCR7 as a major signaling pathway for CD14+CD16+ monocyte transmigration across the blood brain barrier, and its…”
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