Search Results - "Douglas, Ross G"

Divergent Plasmodium actin residues are essential for filament localization, mosquito salivary gland invasion and malaria transmission by Yee, Michelle, Walther, Tobias, Frischknecht, Friedrich, Douglas, Ross G

“…Actin is one of the most conserved and ubiquitous proteins in eukaryotes. Its sequence has been highly conserved for its monomers to self-assemble into…”
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Active migration and passive transport of malaria parasites by Douglas, Ross G, Amino, Rogerio, Sinnis, Photini, Frischknecht, Freddy

“…Highlights • Plasmodium undergoes active migration and passive transport during its lifecycle. • Recent literature displays misunderstanding as to when…”
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Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments by Douglas, Ross G, Nandekar, Prajwal, Aktories, Julia-Elisabeth, Kumar, Hirdesh, Weber, Rebekka, Sattler, Julia M, Singer, Mirko, Lepper, Simone, Sadiq, S Kashif, Wade, Rebecca C, Frischknecht, Friedrich

“…Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments. In metazoans, monomeric actin…”
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Screening for potential prophylactics targeting sporozoite motility through the skin by Douglas, Ross G, Reinig, Miriam, Neale, Matthew, Frischknecht, Friedrich

“…Anti-malarial compounds have not yet been identified that target the first obligatory step of infection in humans: the migration of Plasmodium sporozoites in…”
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Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors by Douglas, Ross G, Sharma, Rajni K, Masuyer, Geoffrey, Lubbe, Lizelle, Zamora, Ismael, Acharya, K Ravi, Chibale, Kelly, Sturrock, Edward D

“…ACE (angiotensin-1-converting enzyme) is a zinc metallopeptidase that plays a prominent role in blood pressure regulation and electrolyte homeostasis. ACE…”
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A small mitochondrial protein present in myzozoans is essential for malaria transmission by Klug, Dennis, Mair, Gunnar R., Frischknecht, Friedrich, Douglas, Ross G.

“…Myzozoans (which include dinoflagellates, chromerids and apicomplexans) display notable divergence from their ciliate sister group, including a reduced…”
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Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme by Kröger, Wendy L, Douglas, Ross G, O’Neill, Hester G, Dive, Vincent, Sturrock, Edward D

“…Human somatic angiotensin-converting enzyme (ACE) is a membrane-bound dipeptidyl carboxypeptidase that contains two extracellular domains (N and C). Although…”
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A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP by Danilov, Sergei M, Wade, Michael S, Schwager, Sylva L, Douglas, Ross G, Nesterovitch, Andrew B, Popova, Isolda A, Hogarth, Kyle D, Bhardwaj, Nakul, Schwartz, David E, Sturrock, Edward D, Garcia, Joe G N

“…Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active…”
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Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites by Douglas, Ross G, Moon, Robert W, Frischknecht, Friedrich

“…Apicomplexan parasites are a group of eukaryotic protozoans with diverse biology that have affected human health like no other group of parasites. These…”
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The 2001 uses of GFP: A review of "Illuminating Disease" by Douglas, Ross G., Frischknecht, Freddy

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Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme by Masuyer, Geoffrey, Douglas, Ross G., Sturrock, Edward D., Acharya, K. Ravi

“…Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and…”
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The Dynamic Nonprime Binding of Sampatrilat to the C‑Domain of Angiotensin-Converting Enzyme by Sharma, Rajni K, Espinoza-Moraga, Marlene, Poblete, Horacio, Douglas, Ross G, Sturrock, Edward D, Caballero, Julio, Chibale, Kelly

“…Sampatrilat is a vasopeptidase inhibitor that inhibits both angiotensin I-converting enzyme (ACE) and neutral endopeptidase. ACE is a zinc dipeptidyl…”
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Kinetic and structural characterization of amyloid‐β peptide hydrolysis by human angiotensin‐1‐converting enzyme by Larmuth, Kate M., Masuyer, Geoffrey, Douglas, Ross G., Schwager, Sylva L., Acharya, K. Ravi, Sturrock, Edward D.

“…Angiotensin‐1‐converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities…”
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Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): Opportunities for angiotensin-converting enzyme inhibitor design by Douglas, Ross G, Ehlers, Mario R, Sturrock, Edward D

“…Summary  The renin–angiotensin system (RAS) is central to regulation of blood pressure and electrolyte homeostasis.  Angiotensin‐converting enzyme (ACE), a key…”
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New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme by Sharma, Rajni K, Douglas, Ross G, Louw, Stefan, Chibale, Kelly, Sturrock, Edward D

“…Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase containing two homologous domains. While the C-domain plays a major role in blood pressure…”
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Characterization of angiotensin I-converting enzyme N-domain selectivity using positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides by Bersanetti, Patrícia A, Sabatini, Regiane A, Matos, Beatriz S, Douglas, Ross G, Nchinda, Aloysius, Juliano, Maria A, Pesquero, João Bosco, Sturrock, Edward D, Carmona, Adriana K

“…Somatic angiotensin I-converting enzyme (ACE)has two homologous active sites (N and C domains) that show differences in various biochemical properties.In a…”
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Kinetic and structural characterization of amyloid-[beta] peptide hydrolysis by human angiotensin-1-converting enzyme by Larmuth, Kate M, Masuyer, Geoffrey, Douglas, Ross G, Schwager, Sylva L, Acharya, K Ravi, Sturrock, Edward D

“…Angiotensin-1-converting enzyme (ACE), a zinc metallopeptidase, consists of two homologous catalytic domains (N and C) with different substrate specificities…”
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A Novel Angiotensin I-Converting Enzyme Mutation by Danilov, Sergei M, Wade, Michael S, Schwager, Sylva L, Douglas, Ross G, Nesterovitch, Andrew B, Popova, Isolda A, Hogarth, Kyle D, Bhardwaj, Nakul, Schwartz, David E, Sturrock, Edward D, Garcia, Joe G. N

“…Background Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of…”
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A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP: e88001 by Danilov, Sergei M, Wade, Michael S, Schwager, Sylva L, Douglas, Ross G, Nesterovitch, Andrew B, Popova, Isolda A, Hogarth, Kyle D, Bhardwaj, Nakul, Schwartz, David E, Sturrock, Edward D

“…Background Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of…”
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