Search Results - "Douglas, McMillan"

CYP-mediated drug metabolism in the brain impacts drug response by McMillan, Douglas M., Tyndale, Rachel F.

“…The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and evolving field of research. CYPs are present and active in the brain, with…”
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Association of early caffeine administration and neonatal outcomes in very preterm neonates by Lodha, Abhay, Seshia, Mary, McMillan, Douglas D, Barrington, Keith, Yang, Junmin, Lee, Shoo K, Shah, Prakesh S

“…Advantages of caffeine for apnea of prematurity have prompted clinicians to use it prophylactically even before apnea. To determine the effect of early…”
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Outcomes and care practices for preterm infants born at less than 33 weeks' gestation: a quality-improvement study by Lee, Shoo K, Beltempo, Marc, McMillan, Douglas D, Seshia, Mary, Singhal, Nalini, Dow, Kimberly, Aziz, Khalid, Piedboeuf, Bruno, Shah, Prakesh S

“…Preterm birth is the leading cause of morbidity and mortality in children younger than 5 years. We report the changes in neonatal outcomes and care practices…”
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Automated versus manual control of inspired oxygen to target oxygen saturation in preterm infants: a systematic review and meta-analysis by Mitra, Souvik, Singh, Balpreet, El-Naggar, Walid, McMillan, Douglas D.

“…Objectives To conduct a systematic review of clinical trials comparing automated versus manual fraction of inspired oxygen (FiO 2 ) control to target oxygen…”
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A multicenter study on the clinical outcome of chorioamnionitis in preterm infants by Soraisham, Amuchou S., MD, Singhal, Nalini, MD, McMillan, Douglas D., MD, Sauve, Reg S., MD, Lee, Shoo K., PhD

“…Objective The purpose of this study was to examine the effects of clinical maternal chorioamnionitis on morbidity and mortality rates among infants who are at…”
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Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine by McMillan, Douglas M, Tyndale, Rachel F

“…CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood-brain barrier, and active efflux,…”
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Development and Impact of Helping Babies Breathe Educational Methodology by Singhal, Nalini, McMillan, Douglas D, Savich, Renate, Matovelo, Dismas, Santorino, Data, Kamath-Rayne, Beena D

“…The educational pedagogy surrounding Helping Babies Breathe (HBB) has been transformative in going beyond a curriculum focused only on basic neonatal…”
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Beyond Newborn Resuscitation: Essential Care for Every Baby and Small Babies by Berkelhamer, Sara K, McMillan, Douglas D, Amick, Erick, Singhal, Nalini, Bose, Carl L

“…Helping Babies Breathe (HBB) addresses a major cause of newborn mortality by teaching basic steps of neonatal resuscitation and improving survival rates of…”
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Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response by McMillan, Douglas M., Tyndale, Rachel F.

“…[Display omitted] Repeated opioid administration produces analgesic tolerance, which may lead to dose escalation. Brain CYP2D metabolizes codeine to morphine,…”
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Wisdom from the well by McMillan, Douglas D

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Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats by McMillan, Douglas M., El-Sherbeni, Ahmed A., Richards, Janielle, Tyndale, Rachel F.

“…•Tramadol is an opioid with inhibitory actions on serotonin/norepinephrine reuptake.•Role of CYP2D metabolism on tramadol analgesia unclear; brain CYP2D may…”
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Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia by McMillan, Douglas M., Miksys, Sharon, Tyndale, Rachel F.

“…Oxycodone is metabolized by CYP2D to oxymorphone. Despite oxymorphone being a more potent opioid‐receptor agonist, its contribution to oxycodone analgesia may…”
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Prevalence and Diversity of Plant Parasitic Nematodes in Irish Peatlands by Pulavarty, Anusha, Klappauf, Tilman, Singh, Ankit, Molero Molina, Patricia, Godjo, Anique, Molleman, Bastiaan, McMillan, Douglas, Kakouli-Duarte, Thomais

“…The prevalence of plant parasitic nematodes (PPN) in the Irish peatlands was investigated in five different peatland habitats—raised bog, cutover…”
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Mapping the restoration of degraded peatland as a research area: A scientometric review by Apori, Samuel Obeng, Mcmillan, Douglas, Giltrap, Michelle, Tian, Furong

“…Degraded peatland has reduced many ecosystem services, such as water quality and quantity, biodiversity, carbon storage, climate regulations, and other…”
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First-step validation of a text message-based application for newborn clinical management among pediatricians by Data, Santorino, Mukama, Martin, McMillan, Douglas, Singhal, Nalini, Bajunirwe, Francis

“…Neonatal mortality is high in developing countries. Lack of adequate training and insufficient management skills for sick newborn care contribute to these…”
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Can volunteer community health workers decrease child morbidity and mortality in southwestern Uganda? An impact evaluation by Brenner, Jennifer L, Kabakyenga, Jerome, Kyomuhangi, Teddy, Wotton, Kathryn A, Pim, Carolyn, Ntaro, Moses, Bagenda, Fred Norman, Gad, Ndaruhutse Ruzazaaza, Godel, John, Kayizzi, James, McMillan, Douglas, Mulogo, Edgar, Nettel-Aguirre, Alberto, Singhal, Nalini

“…The potential for community health workers to improve child health in sub-Saharan Africa is not well understood. Healthy Child Uganda implemented a volunteer…”
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Do We Need an Intubation-Skilled Person at All High-Risk Deliveries? by Almudeer, Ali, MD, McMillan, Douglas, MD, O'Connell, Colleen, PhD, El-Naggar, Walid, MD

“…Objective To evaluate the significance and predictive value of each of the Neonatal Resuscitation Program (NRP)-listed ante- and intrapartum risk factors for…”
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SNAP-II for prediction of mortality and morbidity in extremely preterm infants by Beltempo, Marc, Shah, Prakesh S., Ye, Xiang Y., Afifi, Jehier, Lee, Shoo, McMillan, Douglas D.

“…Objective: To determine the specific Score of Neonatal Acute Physiology (SNAP-II) cut-off scores associated with outcomes in extremely preterm infants, and to…”
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Prior leg massage decreases pain responses to heel stick in preterm babies by Jain, Sunil, Kumar, Praveen, McMillan, Douglas D

“…Aim:  Leg massage could inhibit the transmission of pain by ‘closing the gate’ or by activating the endogenous opioid pathway to decrease nociceptive…”
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Participants' Perceptions of Essential Coaching for Every Mother-a Canadian Text Message-Based Postpartum Program: Process Evaluation of a Randomized Controlled Trial by Dol, Justine, Aston, Megan, McMillan, Douglas, Tomblin Murphy, Gail, Campbell-Yeo, Marsha

“…"Essential Coaching for Every Mother" is a Canadian text message-based program that sends daily messages to mothers for 6 weeks after they give birth. There is…”
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