Search Results - "Douglas, Lisa E.J."

Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease by Ouyang, Xuan, Reihill, James A, Douglas, Lisa E J, Martin, S Lorraine

“…Common airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system…”
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Furin as a therapeutic target in cystic fibrosis airways disease by Douglas, Lisa E J, Reihill, James A, Montgomery, Bethany M, Martin, S Lorraine

“…Clinical management of cystic fibrosis (CF) has been greatly improved by the development of small molecule modulators of the CF transmembrane conductance…”
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A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier Dysfunction by Reihill, James A, Ouyang, Xuan, Yang, Zhixuan, Douglas, Lisa E J, Zhou, Mei, Chen, Tianbao, Martin, S Lorraine

“…Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease…”
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BOS-318 treatment enhances elexacaftor-tezacaftor-ivacaftor (ETI)-mediated improvements in airways hydration and mucociliary transport by Douglas, Lisa E.J., Reihill, James A., Martin, S. Lorraine

“…Background CFTR triple modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI) has transformed care for people with cystic fibrosis (pwCF) who have eligible…”
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House dust mite allergens induce Ca2+ signalling and alarmin responses in asthma airway epithelial cells by Ouyang, Xuan, Reihill, James A., Douglas, Lisa E.J., Dunne, Orla M., Sergeant, Gerard P., Martin, S. Lorraine

“…Type 2 inflammation in asthma develops with exposure to stimuli to include inhaled allergens from house dust mites (HDM). Features include mucus hypersecretion…”
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Furin Inhibition as a Mechanism to Reduce Aberrant ENaC‐Mediated Sodium Transport and Rehydrate the Airways in Cystic Fibrosis Lung Disease by Douglas, Lisa E.J., Reihill, James A., Ho, Melisa W.‐Y., Axten, Jeffrey M., Martin, S. Lorraine

“…The epithelial sodium channel (ENaC) is found in a number of tissues including lung epithelia and is activated through proteolytic cleavage of its α and γ…”
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The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis by Melhim, Suhad Bani, Douglas, Lisa E.J., Reihill, James A., Downey, Damian G., Martin, S. Lorraine

“…Inflammation in cystic fibrosis (CF) airways is difficult to treat with well-established regimens often including azithromycin (AZ) as an immunomodulatory…”
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The Secretory Profile of Inflammatory Mediators is Altered in Differentiated Primary COPD Samples at Air Liquid Interface Compared to Healthy Equivalents by Kelly, Gillian A., Douglas, Lisa E.J., Maye, Jessica R., Reihill, James A., McGarvey, Lorcan P., Lundy, Fionnuala T., Litherland, Gary, Martin, S. Lorraine

“…In the UK, over 1 million people live with diagnosed chronic obstructive pulmonary disease (COPD) however, it is estimated that this is only 1/3 of the total…”
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Inhibition of ENaC Activity by Novel Peptide Trypsin‐Like Inhibitors Derived from Amphibian Skin Secretions by Carroll, Emma L., Douglas, Lisa E.J., Reihill, James A., Zhou, Mei, Chen, Tianbao, McGarvey, Lorcan P., Lundy, Fionnuala T., Hollywood, Mark A., Lockhart, John C., Martin, S. Lorraine

“…Impaired mucociliary clearance (MCC) constitutes the main hallmark of the chronic bronchitis phenotype in COPD. Whilst aberrant processes involved in mucus…”
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Modulation of Ion Transport to Restore Airway Hydration in Cystic Fibrosis by Reihill, James A, Douglas, Lisa E J, Martin, S Lorraine

“…Cystic fibrosis (CF) is a life-limiting genetic disorder caused by loss-of-function mutations in the gene which codes for the CF transmembrane conductance…”
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