Search Results - "Douglas, Janet L"

Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism by DOUGLAS, Janet L, VISWANATHAN, Kasinath, MCCARROLL, Matthew N, GUSTIN, Jean K, FRÜH, Klaus, MOSES, Ashlee V

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Molecular Mechanism of BST2/Tetherin Downregulation by K5/MIR2 of Kaposi's Sarcoma-Associated Herpesvirus by MANSOURI, Mandana, VISWANATHAN, Kasinath, DOUGLAS, Janet L, HINES, Jennie, GUSTIN, Jean, MOSES, Ashlee V, FRÜH, Klaus

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The great escape: viral strategies to counter BST-2/tetherin by Douglas, Janet L, Gustin, Jean K, Viswanathan, Kasinath, Mansouri, Mandana, Moses, Ashlee V, Früh, Klaus

“…The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and…”
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Viral takeover of the host ubiquitin system by Gustin, Jean K, Moses, Ashlee V, Früh, Klaus, Douglas, Janet L

“…Like the other more well-characterized post-translational modifications (phosphorylation, methylation, acetylation, acylation, etc.), the attachment of the 76…”
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Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131 by Cihlar, Tomas, Ray, Adrian S, Boojamra, Constantine G, Zhang, Lijun, Hui, Hon, Laflamme, Genevieve, Vela, Jennifer E, Grant, Deborah, Chen, James, Myrick, Florence, White, Kirsten L, Gao, Ying, Lin, Kuei-Ying, Douglas, Janet L, Parkin, Neil T, Carey, Anne, Pakdaman, Rowchanak, Mackman, Richard L

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Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148 by Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., Cihlar, Tomas

“…GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosphonic acid] 4 is a novel nucleoside phosphonate HIV-1 reverse transcriptase (RT)…”
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Small Molecules VP-14637 and JNJ-2408068 Inhibit Respiratory Syncytial Virus Fusion by Similar Mechanisms by DOUGLAS, Janet L, PANIS, Marites L, HO, Edmund, LIN, Kuei-Ying, KRAWCZYK, Steve H, GRANT, Deborah M, CAI, Ruby, SWAMINATHAN, Swami, XIAOWU CHEN, CIHLAR, Tomas

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Inhibition of Respiratory Syncytial Virus Fusion by the Small Molecule VP-14637 via Specific Interactions with F Protein by Douglas, Janet L, Panis, Marites L, Ho, Edmund, Lin, Kuei-Ying, Krawczyk, Steve H, Grant, Deborah M, Cai, Ruby, Swaminathan, Swami, Cihlar, Tomas

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Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin by Gustin, Jean K., Bai, Ying, Moses, Ashlee V., Douglas, Janet L.

“…Background. BST2/tetherin is an innate immune molecule with the unique ability to restrict the egress of human immunodeficiency virus (HIV) and other enveloped…”
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Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain by Gustin, Jean K., Douglas, Janet L., Bai, Ying, Moses, Ashlee V.

“…The cellular protein BST-2/CD317/Tetherin has been shown to inhibit the release of HIV-1 and other enveloped viruses from infected cells. The HIV-1 accessory…”
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A comparative mutational analysis of HIV-1 Vpu subtypes B and C for the identification of determinants required to counteract BST-2/Tetherin and enhance viral egress by Douglas, Janet L, Bai, Ying, Gustin, Jean K, Moses, Ashlee V

“…Abstract We have undertaken a genetic strategy to map Vpu regions necessary for BST-2 antagonism and viral egress. This approach is based on our identification…”
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Characterization of c-Kit expression and activation in KSHV-infected endothelial cells by Douglas, Janet L, Whitford, Jill G, Moses, Ashlee V

“…Abstract Kaposi's sarcoma (KS) herpesvirus (KSHV) is the etiological agent of several immunodeficiency-linked cancers, including KS. Our previous work showed…”
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In search of a small-molecule inhibitor for respiratory syncytial virus by Douglas, Janet L

“…Respiratory syncytial virus has been an ongoing health problem for 50 years. Hospitalization rates due to virus-induced respiratory illness continue to be…”
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Lentivirus-based vectors transduce mouse hematopoietic stem cells with similar efficiency to Moloney murine leukemia virus–based vectors by Barrette, Stephane, Douglas, Janet L., Seidel, Nancy E., Bodine, David M.

“…The low levels of transduction of human hematopoietic stem cells (HSCs) with Moloney murine leukemia virus (MLV) vectors have been an obstacle to gene therapy…”
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Efficient human immunodeficiency virus-based vector transduction of unstimulated human mobilized peripheral blood CD34+ cells in the SCID-hu Thy/Liv model of human T cell lymphopoiesis by Douglas, J L, Lin, W Y, Panis, M L, Veres, G

“…The methods available to efficiently transduce human CD34(+) hematopoietic stem cells (HSCs) derived from mobilized peripheral blood, such that they fully…”
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The Great Escape: Viral Strategies to Counter BST-2/Tetherin: e1000913 by Douglas, Janet L, Gustin, Jean K, Viswanathan, Kasinath, Mansouri, Mandana, Moses, Ashlee V, Früh, Klaus

“…The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and…”
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115 HIV Vpu complexes with βTrCP to direct the degradation of the virus release inhibitor BST-2 (Tetherin) by Douglas, Janet L, Viswanathan, Kasinath, McCarroll, Matthew N, Gustin, Jean K, Fruh, Klaus, Moses, Ashlee V

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Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism by Douglas, Janet L, Viswanathan, Kasinath, McCarroll, Matthew N, Gustin, Jean K, Früh, Klaus, Moses, Ashlee V

“…The primary roles attributed to the human immunodeficiency virus type 1 (HIV-1) Vpu protein are the degradation of the viral receptor CD4 and the enhancement…”
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Infectivity Enhancement by HIV-1 Nef Is Dependent on the Pathway of Virus Entry: Implications for HIV-Based Gene Transfer Systems by Luo, Tianci, Douglas, Janet L., Livingston, Robyn L., Garcia, J.Victor

“…Retroviruses have been extensively used in the development of gene transfer systems. Recently, there has been a great deal of interest in the use of…”
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The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion by Chien, M L, Foster, J L, Douglas, J L, Garcia, J V

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