Search Results - "Douglas, James C."

Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders by Drew, Paul D., Johnson, Jennifer W., Douglas, James C., Phelan, Kevin D., Kane, Cynthia J. M.

“…Background Fetal alcohol spectrum disorders (FASD) result from fetal exposure to alcohol and are the leading cause of mental retardation in the United States…”
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Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence by Cealie, MaKenna Y, Douglas, James C, Le, Linh H D, Vonkaenel, Erik D, McCall, Matthew N, Drew, Paul D, Majewska, Ania K

“…Fetal alcohol spectrum disorders (FASD) are the most common cause of non-heritable, preventable mental disability, occurring in almost 5% of births in the…”
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Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset by Holloway, Kalee N, Douglas, James C, Rafferty, Tonya M, Majewska, Ania K, Kane, Cynthia J M, Drew, Paul D

“…Fetal alcohol spectrum disorders (FASD) are a group of neurodevelopmental disorders caused by ethanol exposure , which can result in neurocognitive and…”
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Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity by Xu, Jihong, Wagoner, Gail, Douglas, James C., Drew, Paul D.

“…LXR agonists alter Th17 cell function and suppress EAE. CD4+ Th17 cells are believed to play an important role in the development of a variety of autoimmune…”
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Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling by Holloway, Kalee N, Douglas, James C, Rafferty, Tonya M, Kane, Cynthia J M, Drew, Paul D

“…Ethanol induces neuroinflammation, which is believed to contribute to the pathogenesis of alcohol use disorder (AUD). Toll-like receptors (TLRs) are a group of…”
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum by Cealie, MaKenna Y, Douglas, James C, Swan, Hannah K, Vonkaenel, Erik D, McCall, Matthew N, Drew, Paul D, Majewska, Ania K

“…Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar…”
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Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression by Holloway, Kalee N, Pinson, Marisa R, Douglas, James C, Rafferty, Tonya M, Kane, Cynthia J M, Miranda, Rajesh C, Drew, Paul D

“…Alcohol use disorder (AUD) is one of the most common preventable mental health disorders and can result in pathology within the CNS, including the cerebellum…”
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Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period by Pinson, Marisa R., Holloway, Kalee N., Douglas, James C., Kane, Cynthia J. M., Miranda, Rajesh C., Drew, Paul D.

“…Background The developing hippocampus and cerebellum, unique among brain regions, exhibit a secondary surge in neurogenesis during the third trimester of…”
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Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders by Kane, Cynthia J. M., Douglas, James C., Rafferty, Tonya, Johnson, Jennifer W., Niedzwiedz‐Massey, Victoria M., Phelan, Kevin D., Majewska, Ania Katarzyna, Drew, Paul D.

“…Fetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant personal and societal loss, and there is no effective treatment for these…”
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Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice by Kane, Cynthia J. M., Phelan, Kevin D., Douglas, James C., Wagoner, Gail, Johnson, Jennifer W., Xu, Jihong, Phelan, Patrick S., Drew, Paul D.

“…Background Alcohol use occurs across the life span beginning in adolescence and continuing through adulthood. Ethanol (EtOH)‐induced pathology varies with age…”
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Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders by Niedzwiedz-Massey, Victoria M., Douglas, James C., Rafferty, Tonya, Wight, Patricia A., Kane, Cynthia J.M., Drew, Paul D.

“…Fetal alcohol spectrum disorders (FASD) are alarmingly common and result in significant personal and societal loss. Neuropathology of the hippocampus is common…”
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Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation by Niedzwiedz-Massey, Victoria M., Douglas, James C., Rafferty, Tonya, Johnson, Jennifer W., Holloway, Kalee N., Berquist, Michael D., Kane, Cynthia J.M., Drew, Paul D.

“…Background: Hippocampal and cerebellar neuropathology occurs in individuals with alcohol use disorders (AUD), resulting in impaired cognitive and motor…”
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Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders by Niedzwiedz-Massey, Victoria M., Douglas, James C., Rafferty, Tonya, Kane, Cynthia J.M., Drew, Paul D.

“…Fetal alcohol spectrum disorders (FASD) are alarmingly common, result in significant personal and societal loss, and there are no effective treatments for…”
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Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone by Cippitelli, Andrea, Domi, Esi, Ubaldi, Massimo, Douglas, James C, Li, Hong Wu, Demopulos, Gregory, Gaitanaris, George, Roberto, Marisa, Drew, Paul D, Kane, Cynthia J.M, Ciccocioppo, Roberto

“…Highlights • The PPARγ agonist pioglitazone reduces alcohol-induced neurodegeneration. • Pioglitazone prevents alcohol-induced expression of pro-inflammatory…”
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Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists by Kane, Cynthia J.M, Phelan, Kevin D, Han, Lihong, Smith, Renea R, Xie, Jin, Douglas, James C, Drew, Paul D

“…Highlight ► We demonstrate that PPAR-γ agonists protect neurons and microglia from ethanol induced neuropathology in primary cultures and in a novel in vivo…”
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β-Lapachone ameliorization of experimental autoimmune encephalomyelitis by Xu, Jihong, Wagoner, Gail, Douglas, James C, Drew, Paul D

“…Abstract β-Lapachone is a naturally occurring quinine, originally isolated from the bark of the lapacho tree ( Tabebuia avellanedae ) which is currently being…”
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Effects of ethanol on immune response in the brain: region-specific changes in aged mice by Kane, Cynthia J M, Phelan, Kevin D, Douglas, James C, Wagoner, Gail, Johnson, Jennifer Walker, Xu, Jihong, Drew, Paul D

“…Alcohol abuse has dramatic effects on the health of the elderly. Recent studies indicate that ethanol increases immune activity in younger animals and that…”
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Microstructure Development and Fracture Behavior of Plate Steels Containing Ultrafine Ferrite by Hamre, Douglas James C

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