Search Results - "Douglas, E"

UV Signature Mutations by Brash, Douglas E.

“…Sequencing complete tumor genomes and exomes has sparked the cancer field's interest in mutation signatures for identifying the tumor's carcinogen. This review…”
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Multiorganismal Insects: Diversity and Function of Resident Microorganisms by Douglas, Angela E

“…All insects are colonized by microorganisms on the insect exoskeleton, in the gut and hemocoel, and within insect cells. The insect microbiota is generally…”
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Strategies for Enhanced Crop Resistance to Insect Pests by Douglas, Angela E

“…Insect pests are responsible for substantial crop losses worldwide through direct damage and transmission of plant diseases, and novel approaches that…”
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pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures by Pires, Douglas E. V, Blundell, Tom L, Ascher, David B

“…Drug development has a high attrition rate, with poor pharmacokinetic and safety properties a significant hurdle. Computational approaches may help minimize…”
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Polyploidy: an evolutionary and ecological force in stressful times by Van de Peer, Yves, Ashman, Tia-Lynn, Soltis, Pamela S, Soltis, Douglas E

“…Polyploidy has been hypothesized to be both an evolutionary dead-end and a source for evolutionary innovation and species diversification. Although polyploid…”
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Engineering of CRISPR/Cas9-mediated potyvirus resistance in transgene-free Arabidopsis plants by Pyott, Douglas E., Sheehan, Emma, Molnar, Attila

“…Summary Members of the eukaryotic translation initiation factor (eIF) gene family, including eIF4E and its paralogue eIF(iso)4E, have previously been…”
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The microbial exometabolome: ecological resource and architect of microbial communities by Douglas, Angela E

“…All microorganisms release many metabolites, collectively known as the exometabolome. The resultant multi-way cross-feeding of metabolites among microorganisms…”
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Degradation of natural organic matter: A thermodynamic analysis by LaRowe, Douglas E., Van Cappellen, Philippe

“…The oxidative degradation of organic matter is a key process in the biogeochemical functioning of the earth system. Quantitative models of organic matter…”
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Trehalose Is a Versatile and Long-Lived Chaperone for Desiccation Tolerance by Tapia, Hugo, Koshland, Douglas E.

“…Diverse organisms across taxa are desiccation tolerant, capable of surviving extreme water loss. Remarkably, desiccation tolerant organisms can survive years…”
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Mouse model hints at pharmacogenomic strategies for stroke treatment in patients possessing a risk variant by Vaughan, Douglas E

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Molecular and physiological manifestations and measurement of aging in humans by Khan, Sadiya S., Singer, Benjamin D., Vaughan, Douglas E.

“…Summary Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a…”
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Ancient WGD events as drivers of key innovations in angiosperms by Soltis, Pamela S, Soltis, Douglas E

“…•Polyploidy or whole-genome duplication (WGD) is a ubiquitous feature of plant genomes.•Polyploidy is most frequent in angiosperms.•A complex pattern of…”
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PAI-1 in tissue fibrosis by Ghosh, Asish K., Vaughan, Douglas E.

“…Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease. Deregulation of wound healing leads to hyperactivation of…”
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More than money: establishing the importance of a sense of purpose for salespeople by Good, Valerie, Hughes, Douglas E., Wang, Hao

“…Much of the current research on salesperson motivation focuses on extrinsic reward expectancy related to compensation, contests, incentives, and quotas. We…”
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The Precise Temporal Pattern of Prehearing Spontaneous Activity Is Necessary for Tonotopic Map Refinement by Clause, Amanda, Kim, Gunsoo, Sonntag, Mandy, Weisz, Catherine J.C., Vetter, Douglas E., Rűbsamen, Rudolf, Kandler, Karl

“…Patterned spontaneous activity is a hallmark of developing sensory systems. In the auditory system, rhythmic bursts of spontaneous activity are generated in…”
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Eight-Year Estimates of Methane Emissions from Oil and Gas Operations in Western Canada Are Nearly Twice Those Reported in Inventories by Chan, Elton, Worthy, Douglas E. J, Chan, Douglas, Ishizawa, Misa, Moran, Michael D, Delcloo, Andy, Vogel, Felix

“…The provinces of Alberta and Saskatchewan account for 70% of Canada’s methane emissions from the oil and gas sector. In 2018, the Government of Canada…”
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Gastric cancer epidemiology and risk factors by Guggenheim, Douglas E., Shah, Manish A.

“…Gastric cancer is a prevalent yet heterogeneous disease. From diet and lifestyle to genetics and ethnicity, our appreciation of the complexity of gastric…”
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The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance by Biancur, Douglas E., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to the current standards of care. The difficulty in treating this…”
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The Drosophila model for microbiome research by Douglas, Angela E.

“…The gut microbiome is increasingly recognized to play an important role in shaping the health and fitness of animals, including humans. Drosophila is emerging…”
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Housing microbial symbionts: evolutionary origins and diversification of symbiotic organs in animals by Douglas, Angela E

“…In many animal hosts, microbial symbionts are housed within specialized structures known as symbiotic organs, but the evolutionary origins of these structures…”
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