Search Results - "Doughty, Martin L."

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes by Hatten, Mary E, Heintz, Nathaniel, Gong, Shiaoching, Zheng, Chen, Doughty, Martin L, Losos, Kasia, Didkovsky, Nicholas, Schambra, Uta B, Nowak, Norma J, Joyner, Alexandra, Leblanc, Gabrielle

“…The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate…”
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Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells by Zhou, Qiong, Viollet, Coralie, Efthymiou, Anastasia, Khayrullina, Guzal, Moritz, Kasey E, Wilkerson, Matthew D, Sukumar, Gauthaman, Dalgard, Clifton L, Doughty, Martin L

“…Astrocytes respond to central nervous system (CNS) injury and disease by transforming to a reactive astrogliosis cell state that can contribute to either CNS…”
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Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells by Zhou, Qiong, Dalgard, Clifton L, Wynder, Christopher, Doughty, Martin L

“…Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small…”
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Nde1 is required for heterochromatin compaction and stability in neocortical neurons by Chomiak, Alison A., Guo, Yan, Kopsidas, Caroline A., McDaniel, Dennis P., Lowe, Clara C., Pan, Hongna, Zhou, Xiaoming, Zhou, Qiong, Doughty, Martin L., Feng, Yuanyi

“…The NDE1 gene encodes a scaffold protein essential for brain development. Although biallelic NDE1 loss of function (LOF) causes microcephaly with profound…”
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SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs by Khayrullina, Guzal, Moritz, Kasey E, Schooley, James F, Fatima, Naheed, Viollet, Coralie, McCormack, Nikki M, Smyth, Jeremy T, Doughty, Martin L, Dalgard, Clifton L, Flagg, Thomas P, Burnett, Barrington G

“…Abstract Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by loss of alpha motor neurons and skeletal muscle atrophy. The disease is…”
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Neurog1 Genetic Inducible Fate Mapping (GIFM) Reveals the Existence of Complex Spatiotemporal Cyto-Architectures in the Developing Cerebellum by Obana, Edwin A., Lundell, Travis G., Yi, Kevin J., Radomski, Kryslaine L., Zhou, Qiong, Doughty, Martin L.

“…Neurog1 is a pro-neural basic helix-loop-helix (bHLH) transcription factor expressed in progenitor cells located in the ventricular zone and subsequently the…”
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Host sex and transplanted human induced pluripotent stem cell phenotype interact to influence sensorimotor recovery in a mouse model of cortical contusion injury by Nieves, Michael D., Furmanski, Orion, Doughty, Martin L.

“…•An adult TBI mouse model of sensorimotor dysfunction in the absence of brain tissue loss used.•Effects of human induced pluripotent stem cell (hiPSC)…”
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Sensorimotor dysfunction in a mild mouse model of cortical contusion injury without significant neuronal loss is associated with increases in inflammatory proteins with innate but not adaptive immune functions by Nieves, Michael D., Furmanski, Orion, Doughty, Martin L.

“…Traumatic brain injury is a leading cause of mortality and morbidity in the United States. Acute trauma to the brain triggers chronic secondary injury…”
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Conditional deletion of Neurog1 in the cerebellum of postnatal mice delays inhibitory interneuron maturation by Obana, Edwin A., Zhou, Qiong, Furmanski, Orion, Doughty, Martin L.

“…The transcriptional programs that drive the generation of diverse GABAergic neuron populations from their common progenitor pools in the developing cerebellum…”
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Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells by Furmanski, Orion, Nieves, Michael D, Doughty, Martin L

“…Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Disease pathology due to TBI progresses from the primary mechanical…”
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Neonatal mouse cortical but not isogenic human astrocyte feeder layers enhance the functional maturation of induced pluripotent stem cell‐derived neurons in culture by Lischka, Fritz W., Efthymiou, Anastasia, Zhou, Qiong, Nieves, Michael D., McCormack, Nikki M., Wilkerson, Matthew D., Sukumar, Gauthaman, Dalgard, Clifton L., Doughty, Martin L.

“…Human induced pluripotent stem (iPS) cell‐derived neurons and astrocytes are attractive cellular tools for nervous system disease modeling and drug screening…”
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Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice by Zhou, Qiong, Obana, Edwin A, Radomski, Kryslaine L, Sukumar, Gauthaman, Wynder, Christopher, Dalgard, Clifton L, Doughty, Martin L

“…The role of epigenetic regulators in the control of adult neurogenesis is largely undefined. We show that the histone demethylase enzyme Kdm5b (Jarid1b)…”
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Cortical contusion injury disrupts olfactory bulb neurogenesis in adult mice by Radomski, Kryslaine L, Zhou, Qiong, Yi, Kevin J, Doughty, Martin L

“…Experimental brain trauma activates quiescent neural stem cells (NSCs) to increase neuronal progenitor cell proliferation in the adult rodent brain. Previous…”
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Role of H3K4 demethylases in complex neurodevelopmental diseases by Wynder, Christopher, Stalker, Leanne, Doughty, Martin L

“…Significant neurological disorders can result from subtle perturbations of gene regulation that are often linked to epigenetic regulation. Proteins that…”
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Neurotrophin-3 promotes cerebellar granule cell exit from the EGL by Doughty, Martin L., Lohof, Ann, Campana, Aline, Delhaye-Bouchaud, Nicole, Mariani, Jean

“…In the cerebellum, the mRNAs for neurotrophin‐3 (NT‐3) and its high‐affinity tyrosine kinase receptor trkC are expressed by both the differentiated granule…”
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Neurodegeneration in Lurcher Mice Occurs via Multiple Cell Death Pathways by Doughty, Martin L, De Jager, Philip L, Korsmeyer, Stanley J, Heintz, Nathaniel

“…Lurcher (Lc) is a gain-of-function mutation in the delta2 glutamate receptor (GRID2) that results in the cell-autonomous death of cerebellar Purkinje cells in…”
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BAC-mediated gene-dosage analysis reveals a role for Zipro1 ( Ru49 / Zfp38 ) in progenitor cell proliferation in cerebellum and skin by Heintz, Nathaniel, Yang, Xiangdong W, Wynder, Christopher, Doughty, Martin L

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Quantitative analysis of cerebellar lobulation in normal and agranular rats by Doughty, Martin L., Delhaye-Bouchaud, Nicole, Mariani, Jean

“…Cerebellar pattern formation was investigated in rats treated with DNA modifying agents. Animals were subjected to combinations of daily injections of…”
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Afferent-Target Cell Interactions in the Cerebellum: Negative Effect of Granule Cells on Purkinje Cell Development in Lurcher Mice by Doughty, Martin L, Lohof, Ann, Selimi, Fekrije, Delhaye-Bouchaud, Nicole, Mariani, Jean

“…Lurcher (Lc) is a gain-of-function mutation in the delta2 glutamate receptor gene that results in a large, constitutive inward current in the cerebellar…”
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