Search Results - "Doughty, John R"

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design by Greenspan, Paul D, Clark, Kirk L, Tommasi, Ruben A, Cowen, Scott D, McQuire, Leslie W, Farley, David L, van Duzer, John H, Goldberg, Ronald L, Zhou, Huanghai, Du, Zhengming, Fitt, John J, Coppa, David E, Fang, Zheng, Macchia, William, Zhu, Lijuan, Capparelli, Michael P, Goldstein, Robert, Wigg, Andrew M, Doughty, John R, Bohacek, Regine S, Knap, Ania K

“…Cathepsin B is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and…”
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Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits by MacPherson, Lawrence J, Bayburt, Erol K, Capparelli, Michael P, Carroll, Brian J, Goldstein, Robert, Justice, Michael R, Zhu, Lijuan, Hu, Shou-ih, Melton, Richard A, Fryer, Lynn, Goldberg, Ron L, Doughty, John R, Spirito, Salvatore, Blancuzzi, Vincent, Wilson, Doug, O'Byrne, Elizabeth M, Ganu, Vishwas, Parker, David T

“…Structure−activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined by taking advantage of a…”
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RED/BLUE INTENSITY RATIOS IN EXPANDING PLANETARY NEBULAE by DOUGHTY, JOHN R., KALER, JAMES B.

“…We have measured the red-to-blue intensity ratios of the Doppler-split emission-line components of six bright planetary nebulae from high-dispersion coudé…”
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