Search Results - "Doughman, Renee"

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions by Anderson, Richard A, Ling, Kun, Doughman, Renee L, Firestone, Ari J, Bunce, Matthew W

“…The ability of cells to form cell contacts, adhere to the extracellular matrix, change morphology, and migrate is essential for development, wound healing,…”
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Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries by Hoffman, Lindsey M, Veldhuijzen van Zanten, Sophie E M, Colditz, Niclas, Baugh, Joshua, Chaney, Brooklyn, Hoffmann, Marion, Lane, Adam, Fuller, Christine, Miles, Lili, Hawkins, Cynthia, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas K, Packer, Roger, Warren, Katherine E, Broniscer, Alberto, Kieran, Mark W, Minturn, Jane, Comito, Melanie, Broxson, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne Sophie, Escorza, Nancy Yanez, Hassall, Timothy, Ziegler, David S, Gottardo, Nicholas, Dholaria, Hetal, Doughman, Renee, Benesch, Martin, Drissi, Rachid, Nazarian, Javad, Jabado, Nada, Boddaert, Nathalie, Varlet, Pascale, Giraud, Géraldine, Castel, David, Puget, Stephanie, Jones, Chris, Hulleman, Esther, Modena, Piergiorgio, Giagnacovo, Marzia, Antonelli, Manila, Pietsch, Torsten, Gielen, Gerrit H, Jones, David T W, Sturm, Dominik, Pfister, Stefan M, Gerber, Nicolas U, Grotzer, Michael A, Pfaff, Elke, von Bueren, André O, Hargrave, Darren, Solanki, Guirish A, Jadrijevic Cvrlje, Filip, Kaspers, Gertjan J L, Vandertop, William P, Grill, Jacques, Bailey, Simon, Biassoni, Veronica, Massimino, Maura, Calmon, Raphaël, Sanchez, Esther, Bison, Brigitte, Warmuth-Metz, Monika, Leach, James, Jones, Blaise, van Vuurden, Dannis G, Kramm, Christof M, Fouladi, Maryam

“…Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for…”
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Front and back by Rho and Rac by Burridge, Keith, Doughman, Renee

“…The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The…”
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MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry by Leach, James L, Roebker, James, Schafer, Austin, Baugh, Joshua, Chaney, Brooklyn, Fuller, Christine, Fouladi, Maryam, Lane, Adam, Doughman, Renee, Drissi, Rachid, DeWire-Schottmiller, Mariko, Ziegler, David S, Minturn, Jane E, Hansford, Jordan R, Wang, Stacie S, Monje-Deisseroth, Michelle, Fisher, Paul G, Gottardo, Nicholas G, Dholaria, Hetal, Packer, Roger, Warren, Katherine, Leary, Sarah E S, Goldman, Stewart, Bartels, Ute, Hawkins, Cynthia, Jones, Blaise V

“…Abtract Background This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone…”
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Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study by Cooney, Tabitha, Lane, Adam, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah E S, Foreman, Nicholas K, Packer, Roger J, Broniscer, Alberto, Minturn, Jane E, Shih, Chie-Schin, Chintagumpala, Murali, Hassall, Tim, Gottardo, Nicholas G, Dholaria, Hetal, Hoffman, Lindsey, Chaney, Brooklyn, Baugh, Joshua, Doughman, Renee, Leach, James L, Jones, Blaise V, Fouladi, Maryam, Warren, Katherine E, Monje, Michelle

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EPID-15. THE INTERNATIONAL DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)/DIFFUSE MIDLINE GLIOMA (DMG) REGISTRY AND REPOSITORY (IDIPGR) EXPANSION by Torontali, Marianne, Doughman, Renee, Chaney, Brooklyn, Black, Katie, Asher, Anthony, Rupert, Andrew, Fuller, Christine, Leach, James, Jones, Blaise, Fouladi, Maryam, DeWire, Mariko

“…Abstract Established in April 2012, the mission of the IDIPGR is to provide secure integrated data sets including clinical, pathologic, radiologic and…”
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EPCT-16. A PHASE IB STUDY OF PTC596 IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA AND HIGH GRADE GLIOMA by Smiley, Natasha Pillay, Baxter, Patricia, Kumar, Shiva, Hwang, Eugene, Breneman, John, Lane, Adam, Doughman, Renee, Deutsch, Michelle, Stevenson, Charles, Stewart, Clinton, Leach, Jim, Li, Xiao-Nan, Romero, Sonia, Maliakal, Pius, Gao, Lan, Fouladi, Maryam, Drissi, Rachid

“…Abstract BACKGROUND BMI-1 is highly expressed in DIPG. Downregulation leads to inhibition of cell proliferation, cell cycle signaling, self-renewal, telomerase…”
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A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas by Hummel, Trent R., Salloum, Ralph, Drissi, Rachid, Kumar, Shiva, Sobo, Matthew, Goldman, Stewart, Pai, Ahna, Leach, James, Lane, Adam, Pruitt, David, Sutton, Mary, Chow, Lionel M., Grimme, Laurie, Doughman, Renee, Backus, Lori, Miles, Lili, Stevenson, Charles, Fouladi, Maryam, DeWire, Mariko

“…Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse…”
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The international diffuse intrinsic pontine glioma registry: an infrastructure to accelerate collaborative research for an orphan disease by Baugh, Joshua, Bartels, Ute, Leach, James, Jones, Blaise, Chaney, Brooklyn, Warren, Katherine E., Kirkendall, Jenavieve, Doughman, Renee, Hawkins, Cynthia, Miles, Lili, Fuller, Christine, Hassall, Tim, Bouffet, Eric, Lane, Adam, Hargrave, Darren, Grill, Jacques, Hoffman, Lindsey M., Jones, Chris, Towbin, Alex, Savage, Sharon A., Monje, Michelle, Li, Xiao-Nan, Ziegler, David S., Veldhuijzen van Zanten, Sophie, Kramm, Christof M., van Vuurden, Dannis G., Fouladi, Maryam

“…Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by…”
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External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry by Veldhuijzen van Zanten, Sophie E. M., Lane, Adam, Heymans, Martijn W., Baugh, Joshua, Chaney, Brooklyn, Hoffman, Lindsey M., Doughman, Renee, Jansen, Marc H. A., Sanchez, Esther, Vandertop, William P., Kaspers, Gertjan J. L., van Vuurden, Dannis G., Fouladi, Maryam, Jones, Blaise V., Leach, James

“…We aimed to perform external validation of the recently developed survival prediction model for diffuse intrinsic pontine glioma (DIPG), and discuss its…”
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Chapter 1 Focal Adhesions: New Angles on an Old Structure by Dubash, Adi D., Menold, Marisa M., Samson, Thomas, Boulter, Etienne, García-Mata, Rafael, Doughman, Renee, Burridge, Keith

“…Focal adhesions have been intensely studied ever since their discovery in 1971. The last three decades have seen major advances in understanding the structure…”
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DIPG-36. CLINICAL, RADIOLOGICAL, AND HISTO-MOLECULAR CHARACTERISTICS OF DIFFUSE INTRINSIC PONTINE GLIOMA IN PATIENTS WHO SURVIVE LESS THAN 3 MONTHS FROM DIAGNOSIS: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY by Dahl, Nathan, Lane, Adam, Bandopadhayay, Pratiti, Minturn, Jane, Dodgshun, Andrew, Parkin, Sara, Shih, Chie-Schin, Hassall, Tim, Hansford, Jordan, Samson, Yvan, Cai, LinBo, Leary, Sarah, Ma, Jie, Bartels, Ute, Hawkins, Cynthia, Monje-Diesseroth, Michelle, Fisher, Paul, Tsui, Karen, Ziegler, David, DeWire-Schottmiller, Mariko, Chaney, Brooklyn, Black, Katie, Doughman, Renee, Leach, James, Jones, Blaise, Fuller, Christine, Fouladi, Maryam, Hoffman, Lindsey

“…Abstract Diffuse intrinsic pontine glioma (DIPG) is aggressive brainstem tumor with median survival of < 1 year. We queried data from the International DIPG…”
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DIPG-70. CLINICAL, RADIOLOGICAL, PATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF CHILDREN <3 YEARS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A REPORT FROM THE INTERNATIONAL DIPG REGISTRY by Bartlett, Allison, Cochrane, Anne, Lane, Adam, Yanez-Escorza, Nancy, Chaney, Brooklyn, Doughman, Renee, DeWire-Schottmiller, Mariko, Goldman, Stewart, Warren, Kathy, Bandopadhayay, Pratiti, Foreman, Nicholas, Shih, Chie-Schin, Minturn, Jane, Bartels, Ute, Packer, Roger, Nazarian, Javad, Hassall, Tim, Samson, Yvan, Monje-Deisseroth, Michelle, Fisher, Paul, Wagner, Lars, Koschmann, Carl, Ziegler, David, Kieran, Mark, Hawkins, Cynthia, White, Peter, Dexheimer, Phillip, Hendershot, Jacob, Drissi, Rachid, Fuller, Christine, Leach, James, Jones, Blaise, Fouladi, Maryam

“…Abstract BACKGROUND Children <3 years with DIPG are reported to have a higher rate of long-term survival (LTS, overall survival (OS) ≥24 months). In patients…”
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DIPG-69. CHARACTERISTICS OF PATIENTS ≥ 10 YEARS OF AGE WITH DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY by Erker, Craig, Lane, Adam, Chaney, Brooklyn, Escorza, Nancy Yanez, Fuller, Christine, Saab, Raya, Kieran, Mark, Packer, Roger, Nazarian, Javad, Minturn, Jane, Dodgshun, Andrew, Parkin, Sarah, Foreman, Nicholas, Broxson, Emmett, Lombardi, Mercedes Garcia, Goldman, Stewart, Sandler, Eric, Warren, Kathy, Greiner, Robert, Gottardo, Nickolas, Dholaria, Hetal, Shih, Chie-Schin, Hassall, Tim, Hansford, Jordan R, Wang, Shiqi Stacie, Samson, Yvan, Leary, Sarah, Ma, Jie, Bartels, Ute, Broniscer, Alberto, Monje, Michelle, Fisher, Paul, Ziegler, David, Wagner, Lars, Koschmann, Carl, Doughman, Renee, Drissi, Rachid, Jones, Blaise, Leach, James, White, Peter, Dexheimer, Phillip, Hendershot, Jacob, Hawkins, Cynthia, Bandopadhayay, Pratiti, Fouladi, Maryam

“…Abstract INTRODUCTION Patients ≥10 years of age with a DIPG are reported to have a higher rate of long-term survival (≥24 months). The purpose of this study…”
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Tyrosine Phosphorylation of Type Iγ Phosphatidylinositol Phosphate Kinase by Src Regulates an Integrin-Talin Switch by Ling, Kun, Doughman, Renee L., Iyer, Vidhya V., Firestone, Ari J., Bairstow, Shawn F., Mosher, Deane F., Schaller, Michael D., Anderson, Richard A.

“…Engagement of integrin receptors with the extracellular matrix induces the formation of focal adhesions (FAs). Dynamic regulation of FAs is necessary for cells…”
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HG-109CONTEMPORARY SURVIVAL ENDPOINTS: AN INTERNATIONAL DIFFUSE INTRINSIC PONTINE GLIOMA REGISTRY STUDY by Cooney, Tabitha, League-Pascual, James, Lane, Adam, Hoffman, Lindsey, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas, Packer, Roger, Broniscer, Alberto, Kieran, Mark, Minturn, Jane, Comito, Melanie, Broxon, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne, Hassall, Tim, Gottardo, Nick, Baugh, Joshua, Chaney, Brooklyn, Doughman, Renee, Leach, James, Jones, Blaise, Fouladi, Maryam, Monje, Michelle, Warren, Kathy

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Membrane Ruffling Requires Coordination between Type Iα Phosphatidylinositol Phosphate Kinase and Rac Signaling by Doughman, Renee L., Firestone, Ari J., Wojtasiak, Michelle L., Bunce, Matthew W., Anderson, Richard A.

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HG-14CLINICAL, RADIOGRAPHIC, AND HISTOLOGIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY by Hoffman, Lindsey M., Bartels, Ute, Miles, Lili, Hawkins, Cynthia, Goldman, Stewart, Leary, Sarah, Hassal, Tim, Minturn, Jane, Packer, Roger, Foreman, Nicholas, Warren, Kathy, Broniscer, Alberto, Broxon, Emmett, Shih, Chie-Schin, Leach, James, Jones, Blaise, Baugh, Josh, Hacker, Brooklyn, Lerme, Brianna, Jones, Chris, Savage, Sharon, Kirkendall, Jenavieve, Doughman, Renee, Wollman, Matt, Millett, Linwood, O'Keefe, Rachel, Bouffet, Eric, van Vuurden, Dannis G., Fouladi, Maryam

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HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES by Hoffman, Lindsey M., van Zanten, Sophie E.M. Veldhuijzen, Colditz, Niclas, Baugh, Joshua, Chaney, Brooklyn, Lane, Adam, Fuller, Christine, Miles, Lili, Hawkins, Cynthia, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas K., Packer, Roger, Warren, Katherine E., Broniscer, Alberto, Kieran, Mark W., Minturn, Jane, Comito, Melanie, Broxon, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne-Sophie, Hassall, Timothy, Ziegler, David, Gottardo, Nick, Dholaria, Hetal, Lerme, Brianna, Kirkendall, Jenavieve, Doughman, Renee, Hoffmann, Marion, Wollman, Matthew, O'Keefe, Rachel, Benesch, Martin, Gerber, Nicolas, Bailey, Simon, Solanki, Guirish, Massimino, Maura, Biassoni, Veronica, Cvrlje, Filip Jadrijevic, Hulleman, Esther, Drissi, Rachid, Nazarian, Javad, Jabado, Nada, von Bueren, Andre Oscar, Pietsch, Torsten, Gielen, Gerrit H., Sturm, Dominik, Jones, David T., Pfister, Stefan, Jones, Chris, Hargrave, Darren, Sanchez, Esther, Bison, Brigitte, Warmuth-Metz, Monika, Leach, James, Jones, Blaise, van Vuurden, Dannis G., Kramm, Christof M., Fouladi, Maryam

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Tyrosine phosphorylation of type Igamma by Ling, Kun, Doughman, Renee L, Iyer, Vidhya V, Firestone, Ari J

“…Engagement of integrin receptors with the extracellular matrix induces the formation of focal adhesions (FAs). Dynamic regulation of FAs is necessary for cells…”
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