Search Results - "Dougherty, Joseph D."

The Expanding Toolkit of Translating Ribosome Affinity Purification by Dougherty, Joseph D

“…Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has…”
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Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders by Xu, Xiaoxiao, Wells, Alan B, O'Brien, David R, Nehorai, Arye, Dougherty, Joseph D

“…Recent advances have substantially increased the number of genes that are statistically associated with complex genetic disorders of the CNS such as autism and…”
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High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation by Lalli, Matthew A, Avey, Denis, Dougherty, Joseph D, Milbrandt, Jeffrey, Mitra, Robi D

“…The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel…”
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Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells by Dougherty, Joseph D, Schmidt, Eric F, Nakajima, Miho, Heintz, Nathaniel

“…We have recently developed a novel method for the affinity purification of the complete suite of translating mRNA from genetically labeled cell populations…”
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Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays by Mulvey, Bernard, Dougherty, Joseph D.

“…Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of…”
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Muscularis macrophage development in the absence of an enteric nervous system by Avetisyan, Marina, Rood, Julia E., Lopez, Silvia Huerta, Sengupta, Rajarshi, Wright-Jin, Elizabeth, Dougherty, Joseph D., Behrens, Edward M., Heuckeroth, Robert O.

“…The nervous system of the bowel regulates the inflammatory phenotype of tissue resident muscularis macrophages (MM), and in adult mice, enteric neurons are the…”
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Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons by Dougherty, Joseph D.

“…We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification(TRAP). Here, we briefly report on the basic…”
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Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
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CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system by Pomper, Nathan, Liu, Yating, Hoye, Mariah L., Dougherty, Joseph D., Miller, Timothy M.

“…microRNAs are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landscape of a cell. Similar to mRNA, they often…”
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Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? by Dougherty, Joseph D., Marrus, Natasha, Maloney, Susan E., Yip, Benjamin, Sandin, Sven, Turner, Tychele N., Selmanovic, Din, Kroll, Kristen L., Gutmann, David H., Constantino, John N., Weiss, Lauren A.

“…Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a “female protective effect” (FPE) envisions males and females have…”
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Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus by Mulvey, Bernard, Bhatti, Dionnet L., Gyawali, Sandeep, Lake, Allison M., Kriaucionis, Skirmantas, Ford, Christopher P., Bruchas, Michael R., Heintz, Nathaniel, Dougherty, Joseph D.

“…Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders…”
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Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development by Usui, Noriyoshi, Co, Marissa, Harper, Matthew, Rieger, Michael A, Dougherty, Joseph D, Konopka, Genevieve

“…Abstract Background Mutations in the gene encoding the transcription factor forkhead box P2 ( FOXP2 ) result in brain developmental abnormalities, including…”
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MYT1L in the making: emerging insights on functions of a neurodevelopmental disorder gene by Chen, Jiayang, Yen, Allen, Florian, Colin P., Dougherty, Joseph D.

“…Large scale human genetic studies have shown that loss of function (LoF) mutations in MYT1L are implicated in neurodevelopmental disorders (NDDs). Here, we…”
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Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain by Sakers, Kristina, Liu, Yating, Llaci, Lorida, Lee, Scott M., Vasek, Michael J., Rieger, Michael A., Brophy, Sean, Tycksen, Eric, Lewis, Renate, Maloney, Susan E., Dougherty, Joseph D.

“…Quaking RNA binding protein (QKI) is essential for oligodendrocyte development as myelination requires myelin basic protein mRNA regulation and localization by…”
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FoxP1 orchestration of ASD-relevant signaling pathways in the striatum by Araujo, Daniel J, Anderson, Ashley G, Berto, Stefano, Runnels, Wesley, Harper, Matthew, Ammanuel, Simon, Rieger, Michael A, Huang, Hung-Chung, Rajkovich, Kacey, Loerwald, Kristofer W, Dekker, Joseph D, Tucker, Haley O, Dougherty, Joseph D, Gibson, Jay R, Konopka, Genevieve

“…Mutations in the transcription factor Forkhead box p1 (FOXP1) are causative for neurodevelopmental disorders such as autism. However, the function of FOXP1…”
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Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons by Görlich, Andreas, Antolin-Fontes, Beatriz, Ables, Jessica L., Frahm, Silke, Ślimak, Marta A., Dougherty, Joseph D., Ibañez-Tallon, Inés

“…The discovery of genetic variants in the cholinergic receptor nicotinic CHRNA5-CHRNA3-CHRNB4 gene cluster associated with heavy smoking and higher relapse risk…”
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Analysis of within Subjects Variability in Mouse Ultrasonic Vocalization: Pups Exhibit Inconsistent, State-Like Patterns of Call Production by Rieger, Michael A, Dougherty, Joseph D

“…Mice produce ultrasonic vocalizations (USV) in multiple communicative contexts, including adult social interaction (e.g., male to female courtship), as well as…”
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An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells by Sapkota, Darshan, Dougherty, Joseph D

“…Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the…”
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DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders by Christian, Diana L., Wu, Dennis Y., Martin, Jenna R., Moore, J. Russell, Liu, Yiran R., Clemens, Adam W., Nettles, Sabin A., Kirkland, Nicole M., Papouin, Thomas, Hill, Cheryl A., Wozniak, David F., Dougherty, Joseph D., Gabel, Harrison W.

“…Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is…”
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Fluoxetine exposure throughout neurodevelopment differentially influences basilar dendritic morphology in the motor and prefrontal cortices by Maloney, Susan E., Tabachnick, Dora R., Jakes, Christine, Avdagic, Selma, Bauernfeind, Amy L., Dougherty, Joseph D.

“…The significance of serotonin (5HT) in mental health is underscored by the serotonergic action of many classes of psychiatric medication. 5HT is known to have…”
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