Search Results - "Dougherty, D. D."

Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function by Widge, A. S., Zorowitz, S., Basu, I., Paulk, A. C., Cash, S. S., Eskandar, E. N., Deckersbach, T., Miller, E. K., Dougherty, D. D.

“…Deep brain stimulation (DBS) is a circuit-oriented treatment for mental disorders. Unfortunately, even well-conducted psychiatric DBS clinical trials have…”
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The Expanding Toolkit of Translating Ribosome Affinity Purification by Dougherty, Joseph D

“…Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has…”
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Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders by Xu, Xiaoxiao, Wells, Alan B, O'Brien, David R, Nehorai, Arye, Dougherty, Joseph D

“…Recent advances have substantially increased the number of genes that are statistically associated with complex genetic disorders of the CNS such as autism and…”
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High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation by Lalli, Matthew A, Avey, Denis, Dougherty, Joseph D, Milbrandt, Jeffrey, Mitra, Robi D

“…The overwhelming success of exome- and genome-wide association studies in discovering thousands of disease-associated genes necessitates developing novel…”
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Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells by Dougherty, Joseph D, Schmidt, Eric F, Nakajima, Miho, Heintz, Nathaniel

“…We have recently developed a novel method for the affinity purification of the complete suite of translating mRNA from genetically labeled cell populations…”
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A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression by Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Howland, Robert H, Bhati, Mahendra T, O’Reardon, John P, Eskandar, Emad N, Baltuch, Gordon H, Machado, Andre D, Kondziolka, Douglas, Cusin, Cristina, Evans, Karleyton C, Price, Lawrence H, Jacobs, Karen, Pandya, Mayur, Denko, Timothey, Tyrka, Audrey R, Brelje, Tim, Deckersbach, Thilo, Kubu, Cynthia, Malone, Donald A

“…Abstract Background Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral…”
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Mapping the subcortical connectivity of the human default mode network by Li, Jian, Curley, William H., Guerin, Bastien, Dougherty, Darin D., Dalca, Adrian V., Fischl, Bruce, Horn, Andreas, Edlow, Brian L.

“…The default mode network (DMN) mediates self-awareness and introspection, core components of human consciousness. Therapies to restore consciousness in…”
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Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
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Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays by Mulvey, Bernard, Dougherty, Joseph D.

“…Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of…”
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FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga by Chiramel, Abhilash I., Dougherty, Jonathan D., Nair, Vinod, Robertson, Shelly J., Best, Sonja M.

“…Selective autophagy of the endoplasmic reticulum (termed ER-phagy) is controlled by members of the FAMI34 reticulon protein family. Here we used mouse…”
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Closing the Loop on Deep Brain Stimulation for Treatment-Resistant Depression by Widge, Alik S, Malone, Jr, Donald A, Dougherty, Darin D

“…Major depressive episodes are the largest cause of psychiatric disability, and can often resist treatment with medication and psychotherapy. Advances in the…”
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Cyclical heat stress during lactation influences the microstructure of the bovine mammary gland by Perez-Hernandez, G., Ellett, M.D., Banda, L.J., Dougherty, D., Parsons, C.L.M., Lengi, A.J., Daniels, K.M., Corl, B.A.

“…The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. This study…”
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Muscularis macrophage development in the absence of an enteric nervous system by Avetisyan, Marina, Rood, Julia E., Lopez, Silvia Huerta, Sengupta, Rajarshi, Wright-Jin, Elizabeth, Dougherty, Joseph D., Behrens, Edward M., Heuckeroth, Robert O.

“…The nervous system of the bowel regulates the inflammatory phenotype of tissue resident muscularis macrophages (MM), and in adult mice, enteric neurons are the…”
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Can the “female protective effect” liability threshold model explain sex differences in autism spectrum disorder? by Dougherty, Joseph D., Marrus, Natasha, Maloney, Susan E., Yip, Benjamin, Sandin, Sven, Turner, Tychele N., Selmanovic, Din, Kroll, Kristen L., Gutmann, David H., Constantino, John N., Weiss, Lauren A.

“…Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a “female protective effect” (FPE) envisions males and females have…”
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Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons by Dougherty, Joseph D.

“…We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification(TRAP). Here, we briefly report on the basic…”
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The Externalizing and Internalizing Pathways to Marijuana Use Initiation: Examining the Synergistic Effects of Impulsiveness and Sensation Seeking by Wasserman, Alexander M., Shaw-Meadow, K. J., Moon, T. J., Karns-Wright, T. E., Mathias, C. W., Hill-Kapturczak, N., Dougherty, D. M.

“…Adolescent marijuana use has become increasingly more problematic compared with the past; thus, understanding developmental processes that increase the…”
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Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity by Crocker, Britni, Ostrowski, Lauren, Williams, Ziv M., Dougherty, Darin D., Eskandar, Emad N., Widge, Alik S., Chu, Catherine J., Cash, Sydney S., Paulk, Angelique C.

“…Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording…”
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Clinical Approach to the Differential Diagnosis Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders by Ducharme, Simon, Price, Bruce H., Larvie, Mykol, Dougherty, Darin D., Dickerson, Bradford C.

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CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system by Pomper, Nathan, Liu, Yating, Hoye, Mariah L., Dougherty, Joseph D., Miller, Timothy M.

“…microRNAs are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landscape of a cell. Similar to mRNA, they often…”
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Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression by Malone, Donald A, Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Friehs, Gerhard M, Eskandar, Emad N, Rauch, Scott L, Rasmussen, Steven A, Machado, Andre G, Kubu, Cynthia S, Tyrka, Audrey R, Price, Lawrence H, Stypulkowski, Paul H, Giftakis, Jonathon E, Rise, Mark T, Malloy, Paul F, Salloway, Stephen P, Greenberg, Benjamin D

“…Background We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression. Methods…”
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