Search Results - "Dougherty, Casey A"

Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery by Chen, Daiqin, Dougherty, Casey A., Zhu, Kaicheng, Hong, Hao

“…Carbon based nanomaterials have attracted significant attention over the past decades due to their unique physical properties, versatile functionalization…”
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Applications of aptamers in targeted imaging: state of the art by Dougherty, Casey A, Cai, Weibo, Hong, Hao

“…Aptamers are single-stranded oligonucleotides with high affinity and specificity to the target molecules or cells, thus they can serve as an important category…”
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Avidity Mechanism of Dendrimer–Folic Acid Conjugates by van Dongen, Mallory A, Silpe, Justin E, Dougherty, Casey A, Kanduluru, Ananda Kumar, Choi, Seok Ki, Orr, Bradford G, Low, Philip S, Banaszak Holl, Mark M

“…Multivalent conjugation of folic acid has been employed to target cells overexpressing folate receptors. Such polymer conjugates have been previously…”
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Hybrid Service-Learning Group Project in the First Semester of a Biochemistry Lecture Course: Developing Interactive Lessons for the Public Library by Dougherty, Casey A

“…A semester-long group project implementing service-learning was designed and executed in the first semester of a two-semester-long biochemistry lecture…”
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In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal–Organic Frameworks Nanomaterials by Chen, Daiqin, Yang, Dongzhi, Dougherty, Casey A, Lu, Weifei, Wu, Hongwei, He, Xianran, Cai, Ting, Van Dort, Marcian E, Ross, Brian D, Hong, Hao

“…Nanoscale metal–organic frameworks (nMOF) materials represent an attractive tool for various biomedical applications. Due to the chemical versatility, enormous…”
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In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide by Yang, Dongzhi, Feng, Liangzhu, Dougherty, Casey A, Luker, Kathryn E, Chen, Daiqin, Cauble, Meagan A, Banaszak Holl, Mark M, Luker, Gary D, Ross, Brian D, Liu, Zhuang, Hong, Hao

“…Abstract Angiogenesis, i.e. the formation of neovasculatures, is a critical process during cancer initiation, progression, and metastasis. Targeting of…”
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Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation by van Dongen, Mallory A, Dougherty, Casey A, Banaszak Holl, Mark M

“…Multivalent polymers offer a powerful opportunity to develop theranostic materials on the size scale of proteins that can provide targeting, imaging, and…”
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Tailoring dendrimer conjugates for biomedical applications: the impact of altering hydrophobicity by Banaszak Holl, Mark M., Dougherty, Casey A., Vaidyanathan, Sriram

“…Hydrophobicity is known to play a key role in the biological distribution of materials but is often an overlooked parameter when conjugating targeting agents,…”
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Quantitative Measurement of Cationic Polymer Vector and Polymer–pDNA Polyplex Intercalation into the Cell Plasma Membrane by Vaidyanathan, Sriram, Anderson, Kevin B, Merzel, Rachel L, Jacobovitz, Binyamin, Kaushik, Milan P, Kelly, Christina N, van Dongen, Mallory A, Dougherty, Casey A, Orr, Bradford G, Banaszak Holl, Mark M

“…Cationic gene delivery agents (vectors) are important for delivering nucleotides, but are also responsible for cytotoxicity. Cationic polymers (L-PEI, jetPEI,…”
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Rapid Exchange Between Free and Bound States in RNA–Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release by Shakya, Anisha, Dougherty, Casey A, Xue, Yi, Al-Hashimi, Hashim M, Banaszak Holl, Mark M

“…A combination of solution NMR, dynamic light scattering (DLS), and fluorescence quenching assays were employed to obtain insights into the dynamics and…”
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Fluorophore:Dendrimer Ratio Impacts Cellular Uptake and Intracellular Fluorescence Lifetime by Dougherty, Casey A, Vaidyanathan, Sriram, Orr, Bradford G, Banaszak Holl, Mark M

“…G5-NH2-TAMRA n (n = 1–4, 5+, and 1.5avg) were prepared with n = 1–4 as a precise dye:dendrimer ratio, 5+ as a mixture of dendrimers with 5 or more dye per…”
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Conjugation Dependent Interaction of Folic Acid with Folate Binding Protein by Merzel, Rachel L, Frey, Carolina, Chen, Junjie, Garn, Rachel, van Dongen, Mallory, Dougherty, Casey A, Kandaluru, Ananda Kumar, Low, Philip S, Marsh, E. Neil G, Banaszak Holl, Mark M

“…Serum proteins play a critical role in the transport, uptake, and efficacy of targeted drug therapies, and here we investigate the interactions between folic…”
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Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios by Manono, Janet, Dougherty, Casey A., Jones, Kirsten, DeMuth, Joshua, Holl, Mark M.Banaszak, DiMaggio, Stassi

“…[Display omitted] The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of…”
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Substrate-Triggered Exosite Binding: Synergistic Dendrimer/Folic Acid Action for Achieving Specific, Tight-Binding to Folate Binding Protein by Chen, Junjie, van Dongen, Mallory A., Merzel, Rachel L., Dougherty, Casey A., Orr, Bradford G., Kanduluru, Ananda Kumar, Low, Philip S., Marsh, E. Neil G., Banaszak Holl, Mark M.

“…Polymer–ligand conjugates are designed to bind proteins for applications as drugs, imaging agents, and transport scaffolds. In this work, we demonstrate a…”
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Isolation and Characterization of Precise Dye/Dendrimer Ratios by Dougherty, Casey A., Furgal, Joseph C., van Dongen, Mallory A., Goodson III, Theodore, Banaszak Holl, Mark M., Manono, Janet, DiMaggio, Stassi

“…Fluorescent dyes are commonly conjugated to nanomaterials for imaging applications using stochastic synthesis conditions that result in a Poisson distribution…”
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Radioactive Nanomaterials for Multimodality Imaging by Chen, Daiqin, Dougherty, Casey A, Yang, Dongzhi, Wu, Hongwei, Hong, Hao

“…Nuclear imaging techniques, including primarily positron emission tomography (PET) and single-photon emission computed tomography (SPECT), can provide…”
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Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging by Yang, Dongzhi, Severin, Gregory W, Dougherty, Casey A, Lombardi, Rachel, Chen, Daiqin, Van Dort, Marcian E, Barnhart, Todd E, Ross, Brian D, Mazar, Andrew P, Hong, Hao

“…Mounting evidence suggests that the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a central role in tumor progression. The goal of this…”
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