Search Results - "Dougan, Gordon"

Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever by Dougan, Gordon, Baker, Stephen

“…Salmonella enterica serovar Typhi, the cause of typhoid, is host restricted to humans. S. Typhi has a monophyletic population structure, indicating that…”
Get full text

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity by Meng, Bo, Abdullahi, Adam, Ferreira, Isabella A. T. M., Goonawardane, Niluka, Saito, Akatsuki, Kimura, Izumi, Yamasoba, Daichi, Gerber, Pehuén Pereyra, Fatihi, Saman, Rathore, Surabhi, Zepeda, Samantha K., Papa, Guido, Kemp, Steven A., Ikeda, Terumasa, Toyoda, Mako, Tan, Toong Seng, Kuramochi, Jin, Mitsunaga, Shigeki, Ueno, Takamasa, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Brevini, Teresa, Mallery, Donna L., Charles, Oscar J., Bowen, John E., Joshi, Anshu, Walls, Alexandra C., Jackson, Laurelle, Martin, Darren, Smith, Kenneth G. C., Bradley, John, Briggs, John A. G., Choi, Jinwook, Madissoon, Elo, Meyer, Kerstin B., Mlcochova, Petra, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Teichmann, Sarah A., Fisher, Andrew J., Pizzuto, Matteo S., de Marco, Anna, Corti, Davide, Hosmillo, Myra, Lee, Joo Hyeon, James, Leo C., Thukral, Lipi, Veesler, David, Sigal, Alex, Sampaziotis, Fotios, Goodfellow, Ian G., Matheson, Nicholas J., Sato, Kei, Gupta, Ravindra K.

“…The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its spike protein 2 . Here we show that the spike protein of Omicron has a…”
Get full text

Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics by Klemm, Elizabeth, Dougan, Gordon

“…The development of next-generation sequencing as a cost-effective technology has facilitated the analysis of bacterial population structure at a whole-genome…”
Get full text

Immunity to salmonellosis by Dougan, Gordon, John, Victoria, Palmer, Sophie, Mastroeni, Pietro

“…Salmonella enterica is a genetically broad species harboring isolates that display considerable antigenic heterogeneity and significant differences in…”
Get full text

Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response by Alasoo, Kaur, Rodrigues, Julia, Mukhopadhyay, Subhankar, Knights, Andrew J., Mann, Alice L., Kundu, Kousik, Hale, Christine, Dougan, Gordon, Gaffney, Daniel J.

“…Regulatory variants are often context specific, modulating gene expression in a subset of possible cellular states. Although these genetic effects can play…”
Get full text

Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study by Meredith, Luke W, Hamilton, William L, Warne, Ben, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Forrest, Sally, Sridhar, Sushmita, Weekes, Michael P, Baker, Stephen, Brown, Nicholas, Moore, Elinor, Popay, Ashley, Roddick, Iain, Reacher, Mark, Gouliouris, Theodore, Peacock, Sharon J, Dougan, Gordon, Török, M Estée, Goodfellow, Ian

“…The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the…”
Get full text

Typhoid in Africa and vaccine deployment by Dougan, Gordon

Get full text

Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa by Feasey, Nicholas A, FRCPath, Dougan, Gordon, PhD, Kingsley, Robert A, PhD, Heyderman, Robert S, PhD, Gordon, Melita A, Dr

“…Summary Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an…”
Get full text

Ventilator-associated pneumonia in critically ill patients with COVID-19 by Maes, Mailis, Higginson, Ellen, Pereira-Dias, Joana, Curran, Martin D, Parmar, Surendra, Khokhar, Fahad, Cuchet-Lourenço, Delphine, Lux, Janine, Sharma-Hajela, Sapna, Ravenhill, Benjamin, Hamed, Islam, Heales, Laura, Mahroof, Razeen, Soderholm, Amelia, Forrest, Sally, Sridhar, Sushmita, Brown, Nicholas M, Baker, Stephen, Navapurkar, Vilas, Dougan, Gordon, Bartholdson Scott, Josefin, Conway Morris, Andrew

“…Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients…”
Get full text

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells by Tchasovnikarova, Iva A., Timms, Richard T., Matheson, Nicholas J., Wals, Kim, Antrobus, Robin, Göttgens, Berthold, Dougan, Gordon, Dawson, Mark A., Lehner, Paul J.

“…Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of…”
Get full text

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease by Walker, Alan W, Sanderson, Jeremy D, Churcher, Carol, Parkes, Gareth C, Hudspith, Barry N, Rayment, Neil, Brostoff, Jonathan, Parkhill, Julian, Dougan, Gordon, Petrovska, Liljana

“…The gut microbiota is thought to play a key role in the development of the inflammatory bowel diseases Crohn's disease (CD) and ulcerative colitis (UC). Shifts…”
Get full text

Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection by Fanning, Saranna, Hall, Lindsay J, Cronin, Michelle, Zomer, Aldert, MacSharry, John, Goulding, David, O'Connell Motherway, Mary, Shanahan, Fergus, Nally, Kenneth, Dougan, Gordon, van Sinderen, Douwe

“…Bifidobacteria comprise a significant proportion of the human gut microbiota. Several bifidobacterial strains are currently used as therapeutic interventions,…”
Get full text

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development by Kraiczy, Judith, Nayak, Komal M, Howell, Kate J, Ross, Alexander, Forbester, Jessica, Salvestrini, Camilla, Mustata, Roxana, Perkins, Sally, Andersson-Rolf, Amanda, Leenen, Esther, Liebert, Anke, Vallier, Ludovic, Rosenstiel, Philip C, Stegle, Oliver, Dougan, Gordon, Heuschkel, Robert, Koo, Bon-Kyoung, Zilbauer, Matthias

“…Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of…”
Get more information

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2 by Tchasovnikarova, Iva A, Timms, Richard T, Douse, Christopher H, Roberts, Rhys C, Dougan, Gordon, Kingston, Robert E, Modis, Yorgo, Lehner, Paul J

“…Paul Lehner and colleagues identify an essential role for MORC2 in HUSH complex–mediated epigenetic silencing. They show that loss of MORC2 causes chromatin…”
Get full text

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis by Deo, Pankaj, Chow, Seong H, Hay, Iain D, Kleifeld, Oded, Costin, Adam, Elgass, Kirstin D, Jiang, Jhih-Hang, Ramm, Georg, Gabriel, Kipros, Dougan, Gordon, Lithgow, Trevor, Heinz, Eva, Naderer, Thomas

“…Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on…”
Get full text

High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya by Kariuki, Samuel, Mbae, Cecilia, Van Puyvelde, Sandra, Onsare, Robert, Kavai, Susan, Wairimu, Celestine, Ngetich, Ronald, Clemens, John, Dougan, Gordon

“…Invasive Non-typhoidal Salmonella (iNTS) disease is a major public health challenge, especially in Sub-Saharan Africa (SSA). In Kenya, mortality rates are high…”
Get full text

Multilocus sequence typing as a replacement for serotyping in Salmonella enterica by Achtman, Mark, Wain, John, Weill, François-Xavier, Nair, Satheesh, Zhou, Zhemin, Sangal, Vartul, Krauland, Mary G, Hale, James L, Harbottle, Heather, Uesbeck, Alexandra, Dougan, Gordon, Harrison, Lee H, Brisse, Sylvain

“…Salmonella enterica subspecies enterica is traditionally subdivided into serovars by serological and nutritional characteristics. We used Multilocus Sequence…”
Get full text

Global dissemination of a multidrug resistant Escherichia coli clone by Petty, Nicola K., Zakour, Nouri L. Ben, Stanton-Cook, Mitchell, Skippington, Elizabeth, Totsika, Makrina, Forde, Brian M., Phan, Minh-Duy, Moriel, Danilo Gomes, Peters, Kate M., Davies, Mark, Rogers, Benjamin A., Dougan, Gordon, Rodriguez-Baño, Jesús, Pascual, Alvaro, Pitout, Johann D. D., Upton, Mathew, Paterson, David L., Walsh, Timothy R., Schembri, Mark A., Beatson, Scott A.

“…Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and…”
Get full text

A current perspective on antimicrobial resistance in Southeast Asia by Zellweger, Raphaël M, Carrique-Mas, Juan, Limmathurotsakul, Direk, Day, Nicholas P J, Thwaites, Guy E, Baker, Stephen

“…Southeast Asia, a vibrant region that has recently undergone unprecedented economic development, is regarded as a global hotspot for the emergence and spread…”
Get full text

The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor by DEAKIN, Laura J, CLARE, Simon, FAGAN, Robert P, DAWSON, Lisa F, PICKARD, Derek J, WEST, Michael R, WREN, Brendan W, FAIRWEATHER, Neil F, DOUGAN, Gordon, LAWLEY, Trevor D

“…OA  Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text