Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from Combretum molle (Combretaceae)
A new compound, combrebisbibenzyl ( ) as well as two sterols including stigmasterol ( ) and 3- -D-glucopyranoside of -sitosterol ( ) and seven triterpenoids namely mollic acid ( ), oleanolic acid ( ), ursolic acid ( ), arjunglucoside I ( , arjungenin ( ), bellericagenin B ( ) and combregenin ( ) wer...
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| Published in: | Zeitschrift für Naturforschung C. A journal of biosciences Vol. 79; no. 11; pp. 377 - 385 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Germany
De Gruyter
26-11-2024
|
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | A new compound, combrebisbibenzyl (
) as well as two sterols including stigmasterol (
) and 3-
-D-glucopyranoside of
-sitosterol (
) and seven triterpenoids namely mollic acid (
), oleanolic acid (
), ursolic acid (
), arjunglucoside I (
, arjungenin (
), bellericagenin B (
) and combregenin (
) were isolated from the root of
. Compounds
,
and
AcOEt and MeOH extracts exhibited moderate antioxidant activity with an IC
value of 179.32, 185.21, 195.11 197.41 and 170.21 μg/mL, respectively, for reactive oxygen species inhibition and, inhibition percent value of 57.23, 64.52, 53.55, 67.42 and 65.04, respectively, for DPPH free-radical scavenging. The
presented a moderate antibacterial activity against
with DIZs value of 10.1 ± 0.2 from 800 μg/mL while the others tested strains were not sensitive. However, most of the tested bacteria, (
,
and
) were moderately sensitive to
from 800 μg/mL with DIZs value of 8.2 ± 0.1. From the E. AcOEt, five of the isolated compounds were tested against four bacteria strains using the disc-dilusion method. The results showed that compound
and
exhibited very good antibacterial activity against all the tested bacteria at the concentration of 30 μg/mL with respective DIZ value of 22.2 and 25.4 for
, 20.2 and 30.2 for
, 22.3 and 23.1 for
and, 22.1 and 24.1 for
. This antibacterial activity significantly depends on the concentration. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0939-5075 1865-7125 1865-7125 |
| DOI: | 10.1515/znc-2023-0087 |