Search Results - "Doublié, Sylvie"

Base Excision Repair in the Mitochondria by Prakash, Aishwarya, Doublié, Sylvie

“…ABSTRACT The 16.5 kb human mitochondrial genome encodes for 13 polypeptides, 22 tRNAs and 2 rRNAs involved in oxidative phosphorylation. Mitochondrial DNA…”
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DNA polymerase θ (POLQ), double-strand break repair, and cancer by Wood, Richard D., Doublié, Sylvie

“…DNA polymerase theta (pol θ) is encoded in the genomes of many eukaryotes, though not in fungi. Pol θ is encoded by the POLQ gene in mammalian cells. The…”
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Genome Protection by DNA Polymerase θ by Wood, Richard D, Doublié, Sylvie

“…DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants. Pol θ uses short DNA sequence homologies to initiate repair of…”
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Human DNA polymerase θ harbors a DNA end-trimming activity critical for DNA repair by Zahn, Karl E., Jensen, Ryan B., Wood, Richard D., Doublié, Sylvie

“…Cancers with hereditary defects in homologous recombination rely on DNA polymerase θ (pol θ) for repair of DNA double-strand breaks. During end-joining, pol θ…”
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Human DNA polymerase θ does not harbor intrinsic nuclease activity by Carvajal-Maldonado, Denisse, Zahn, Karl, Jensen, Ryan, Wood, Richard D, Doublié, Sylvie

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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ by Yousefzadeh, Matthew J, Wyatt, David W, Takata, Kei-Ichi, Mu, Yunxiang, Hensley, Sean C, Tomida, Junya, Bylund, Göran O, Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A, McBride, Kevin M, Wood, Richard D

“…Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been…”
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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair by Zahn, Karl E, Averill, April M, Aller, Pierre, Wood, Richard D, Doublié, Sylvie

“…DNA polymerase θ is involved in alternative end-joining repair of DNA double-strand breaks. Structural and biochemical analyses shed light on pol θ's ability…”
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Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase by Prakash, Aishwarya, Cao, Vy Bao, Doublié, Sylvie

“…The NEIL1 DNA glycosylase is one of eleven mammalian DNA glycosylases that partake in the first step of the base excision repair (BER) pathway. NEIL1…”
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Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping by Yang, Qin, Coseno, Molly, Gilmartin, Gregory M, Doublié, Sylvie

“…Cleavage factor I(m) (CFI(m)) is a highly conserved component of the eukaryotic mRNA 3' processing machinery that functions in sequence-specific poly(A) site…”
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Structural and biochemical insights into NEIL2’s preference for abasic sites by Eckenroth, Brian E, Bumgarner, Joshua D, Matsumoto-Elliott, Olivia, David, Sheila S, Doublié, Sylvie

“…Abstract Cellular DNA is subject to damage from a multitude of sources and repair or bypass of sites of damage utilize an array of context or cell cycle…”
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Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments by Eckenroth, Brian E., Cao, Vy Bao, Averill, April M., Dragon, Julie A., Doublié, Sylvie

“…Oxidative damage on DNA arising from both endogenous and exogenous sources can result in base modifications that promote errors in replication as well as…”
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Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing by Yang, Qin, Gilmartin, Gregory M, Doublié, Sylvie

“…Human Cleavage Factor Im (CFI(m)) is an essential component of the pre-mRNA 3' processing complex that functions in the regulation of poly(A) site selection…”
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The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals by Rohlfing, Amy E, Eckenroth, Brian E, Forster, Emily R, Kevorkian, Yuzo, Donnelly, M Lauren, Benito de la Puebla, Hector, Doublié, Sylvie, Shen, Aimee

“…The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While…”
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Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis by Carroll, Brittany L, Zahn, Karl E, Hanley, John P, Wallace, Susan S, Dragon, Julie A, Doublié, Sylvie

“…Abstract Base excision repair (BER) is the main pathway protecting cells from the continuous damage to DNA inflicted by reactive oxygen species. BER is…”
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Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3' processing by Yang, Qin, Gilmartin, Gregory M, Doublié, Sylvie

“…Human Cleavage Factor Im (CFIm) is an essential component of the pre-mRNA 3' processing complex that functions in the regulation of poly(A) site selection…”
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Structural and functional analysis of the CspB protease required for Clostridium spore germination by Adams, Chloe M, Eckenroth, Brian E, Putnam, Emily E, Doublié, Sylvie, Shen, Aimee

“…Spores are the major transmissive form of the nosocomial pathogen Clostridium difficile, a leading cause of healthcare-associated diarrhea worldwide…”
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Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase by Prakash, Aishwarya, Moharana, Kedar, Wallace, Susan S, Doublié, Sylvie

“…The base excision repair (BER) pathway repairs oxidized lesions in the DNA that result from reactive oxygen species generated in cells. If left unrepaired,…”
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The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage by Prakash, Aishwarya, Doublié, Sylvie, Wallace, Susan S

“…During the initial stages of the base excision DNA repair pathway, DNA glycosylases are responsible for locating and removing the majority of endogenous…”
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Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA by Imamura, Kayo, Averill, April, Wallace, Susan S., Doublié, Sylvie

“…Thymine glycol (Tg) and 5-hydroxyuracil (5-OHU) are common oxidized products of pyrimidines, which are recognized and cleaved by two DNA glycosylases of the…”
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Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity by Mahmoud, Mariam M, Schechter, Allison, Alnajjar, Khadijeh S, Huang, Ji, Towle-Weicksel, Jamie, Eckenroth, Brian E, Doublié, Sylvie, Sweasy, Joann B

“…DNA polymerases synthesize new DNA during DNA replication and repair, and their ability to do so faithfully is essential to maintaining genomic integrity. DNA…”
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